Molecular and functional MDR1-PGP and MRPS expression in human glioblastoma multiforme cell lines

International Journal of Cancer

Volumn 98, Issue 2, 2002, Pages 173-180

  Declèves, Xavier ^a,d,e   Fajac, Anne ^b   Lehmann Che, Jacqueline ^b   Tardy, Marcienne ^c   Mercier, Claire ^a   Hurbain, Ilse ^b   Laplanche, Jean Louis ^d   Bernaudin, Jean François ^b   Scherrmann, Jean Michel ^a  

^a HÔPITAL FERNAND WIDAL   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c FACULTÉ DE MÉDECINE   (France)

^d HÔPITAL LARIBOISIÈRE   (France)

^e INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

8MG; GL15; Glioblastoma multiforme; MRP; P glycoprotein

Indexed keywords

ETOPOSIDE; GLYCOPROTEIN P; INDOMETACIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; PROBENECID; VINCRISTINE;

ARTICLE; CANCER CELL CULTURE; CELL MEMBRANE; CONTROLLED STUDY; DRUG TUMOR LEVEL; GENE EXPRESSION; GLIOBLASTOMA; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 0037051092     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10135     Document Type: Article

References (39)

1. Drug resistance in brain tumors
2. P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain
3. MDR1 P-glycoprotein is expressed by endothelial cells of newly formed capillaries in human gliomas but is not expressed in the neovasculature of other primary tumors
4. Biochemical, cellular, and pharmacological aspects of the multidrug transporter
5. Multidrug resistance-associated protein: A protein distinct from P-glycoprotein involved in cytotoxic drug expulsion
6. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
7. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
8. Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells
9. MRP3, an organic anion transporter able to transport anti-cancer drugs
10. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
11. Expression of multidrug resistance protein-related genes in lung cancer: Correlation with drug response
12. Expression of P-glycoprotein in human glioma cell lines and surgical glioma specimens
13. Mdr1 mRNA expression differs between grade III astrocytomas and glioblastomas
14. P-glycoprotein expression in brain tumors
15. Possible involvement of multidrug-resistance-associated protein (MRP) gene expression in spontaneous drug resistance to vincristine, etoposide and adriamycin in human glioma cells
16. Chemosensitisation of spontaneous multidrug resistance by a 1,4-dihydropyridine analogue and verapamil in human glioma cell lines overexpressing MRP or MDR1
17. Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190kDa membrane protein distinct from P-glycoprotein
18. Expression of multidrug resistance protein gene in patients with glioma after chemotherapy
19. Glial fibrillary protein and its encoding mRNA exhibit mosaic expression in a glioblastoma multiform cell line of clonal origin
20. Characterization of two new permanent glioma cell lines 8-MG-BA and 42-MG-BA
21. Changes in glial fibrillary acidic protein and karyotype during culturing of two cell lines established from human glioblastoma multiforme
22. Effect of differentiating agents on modulation of MDR1 gene expression in multidrug-resistant hematopoietic HL60/DNR cell line
23. Comparative evaluation by semiquantitative reverse transcriptase polymerase chain reaction of MDR1, MRP and GSTp gene expression in breast carcinomas
24. Membrane topology of the multidrug resistance protein (MRP): A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus
25. Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies
26. Different pattern of MRP localization in ciliated and basal cells from human bronchial epithelium
27. Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells
28. Transport properties of the multidrug resistance-associated protein (MRP) in human tumour cells
29. Multidrug resistance in glioblastoma: Chemosensitivity testing and immunohistochemical demonstration of P-glycoprotein
30. Does P-glycoprotein play a role in clinical resistance of malignant astrocytoma?
31. Multidrug resistance gene (MDRI) expression in human brain tumors
32. The multidrug-resistance gene MDR1 is expressed in human glial tumors
33. Functional expression of P-glycoprotein and multidrug resistance-associated protein (Mrp1) in primary cultures of rat astrocytes
34. The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress
35. Multidrug resistance-related proteins in isolated human brain microvessels and in cells cultured from these isolates
36. MRP4: A previously unidentified factor in resistance to nucleoside-based drugs
37. Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs
38. A family of drug transporters: Multidrug resistance-associated proteins
39. The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides