Molecular basis of antimalarial drug resistance in Indonesia

Advances in Experimental Medicine and Biology

Volumn 531, Issue , 2003, Pages 103-115

  Syafruddin, Din ^a,c   Asih, Puji B S ^a   Siregar, Josephine E ^a   Tjitra, Emiliana ^b  

^a EIJKMAN INSTITUTE FOR MOLECULAR BIOLOGY   (Indonesia)

^b NATIONAL INSTITUTE OF HEALTH RESEARCH AND DEVELOPMENT   (Indonesia)

^c HASANUDDIN UNIVERSITY   (Indonesia)

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; ANTIMALARIAL AGENT; ARTEMISININ; ATOVAQUONE; CHLOROQUINE; CYCLOGUANIL; DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; FANSIDAR; FOLIC ACID ANTAGONIST; MEFLOQUINE; PROGUANIL; PROTEIN; PROTEIN PFCRT; PROTEIN PFMDR1; PYRIMETHAMINE; QUININE; SULFADOXINE; SULFONE; UNCLASSIFIED DRUG;

CHROMOSOME 7; CODON; CONFERENCE PAPER; CONTROLLED STUDY; GENE FREQUENCY; HUMAN; INDONESIA; MAJOR CLINICAL STUDY; MALARIA CONTROL; MALARIA FALCIPARUM; MOLECULAR DYNAMICS; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE ISOLATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; TREATMENT FAILURE;

CINCHONA PUBESCENS; PLASMODIUM FALCIPARUM;

EID: 0041382989     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-0059-9_8     Document Type: Conference Paper

References (39)

1. Babiker, H.A., Pringle, S.J., Abdel-Muchsin, A., Mackinnon, M., Hunt, P., and Walliker, D., 2001, High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene, pfcrt and the multidrug resistance gene pfmdrl. J. Iinfect. Dis., 183:1535-1538.
2. Baird, J.K., Fryauff, D.J., Basri, H., Bangs, M.J., Subianto, B., Wiady, I., Purnomo, Leksana, B., Masbar, S., Richie, T.L., et al., 1995, Primaquine for prophylaxis against malaria among nonimmune transmigrants in Irian Jaya, Indonesia. Am. J. Trop. Med. Hyg., 52(6): 479-484.
3. Baird, J. K., Wiady, I., Fryauff, D.J., Sutanihardja, M.A., Leksana, B., Widjaya, H., Kysdarmanto, and Subianto, B., 1997, In vivo resistance to chloroquine by Plasmodium vivax and Plasmodium falciparum at Nabire, Irian Jaya, Indonesia. Am. J. Trop. Med Hyg., 56: 627-631.
4. Basco, L.K., and Ringwald, P., 1997, pfmdrl gene mutation and clinical response to chloroquine in Yaounde, Cameroon. Trans. R. Soc. Trop. Med. Hyg., 91, 210-211.
5. Basco, L. K., and Ringwald, P., 2001, Analysis of the key pfcrt point mutation and in vitro and in vivo response to chloroquine in Yaounde, Cameroon. J. Infect. Dis., 183(12): 1828-1831.
6. Carlton, J.M., Fidock, D.A., Djimde A., Plowe C.V., and Wellems, T.E., 2001, Conservation of a novel vacuolar transporter in Plasmodium species and its central role in chloroquine resistance of Plasmodium falciparum. Curr. Opin. Microbiol. 4(4): 415-420.
7. Cowman, A.F., Morry, M.J., Biggs, B.A., Cross, G.A.M., and Foote, S.J. 1988, Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. Proc. Natl. Acad. Sci. USA, 85: 9109-9113.
8. Cowman, A.F., 1998, The molecular basis of resistance to the sulfones, sulfonamides, and dihydrofolate reductase inhibitors. In Malaria. Parasite Biology, Pathogenesis and Protection (I.W. Sherman, ed.), ASM Press Washington DC, pp. 317-330.
9. Curtis, J., Duraisingh, M.T., Trigg, J.K., Mbwana, H., Warburts, D.C., and Curtis, C. F. 1996, Direct evidence that asparagine at position 108 of the Plasmodium falciparum dihydrofolate reductase is involved in resistance to antifolate drugs in Tanzania. Trans. R. Soc. Trop. Med. Hyg., 90: 678-680.
10. Curtis, J., Duraisingh, M.T., and Warhurst, D.C., 1998, In vivo selection for a specific genotype of dihydropteroate synthase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment. J. Infect. Dis., 177: 1429-1433.
11. Djimde, A., Doumbo O.K., Cortese, J.F., Kayentao, K., Diourte, Y., Doumbo, S., Dicko, A., Su, X.Z., Nomura, T., Fidock, D.A., Wellems, T.E., Plowe, C.V., and Coulibaly, D. 2001, A molecular marker fore chloroquine-resistant falciparum malaria. N. Engl. J. Med., 344: 257-263.
12. Duraisingh, M.T., Curtis, J., and Warhurst, D.C., 1998, Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion. Exp. Parasitol., 89: 1-8.
13. Duraisingh, M.T., Drakeley, C.J., Muller, O., Bailey, R., Snounou, G., Targett, G.A., Greenwood, B.M. and Warhurst, D.C., 1997, Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine. Parasitology, 114: 205-11.
14. Ebisawa, I., and Fukuyama T., 1975a, Chloroquine resistance of Plasmodium falciparum in West Irian and East Kalimantan. Ann. Trop. Med. Parasitol., 69: 131-132.
15. Ebisawa, I. and Fukuyama, T., 1975b, Chloroquine resistance of Plasmodium falciparum in West Irian and East Kalimantan. Ann. Trop. Med. Parasitol., 69: 275-82.
16. Fidock, D.A., Nomura, T., Talley, A.K., Cooper, R.A., Dzekunov, S.M., Ferdig M.T., Ursas L.M.B., Sidhu, A.S., Naude, B., Deltsch, K.W., Su, X.Z., Wootton, J.C., Roepe, P.D., and Wellems, T.E., 2000, Mutations in the P. falciparum digestive vacuole transmembrane protein pfcrt and evidence for their role in chloroquine resistance. Mol. Cell, 5: 861-871.
17. Foote, S.J., Kyle, D.E., Martin, R.K., Oduola, A.M., Forsyth, K., Kemp, D.J., and Cowman, A.F., 1990. Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum. Nature, 345: 255-258.
18. Foote, S. J., Thompson, J. K., Cowman, A. F. and Kemp, D. J. 1989. Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum. Cell, 57: 921-930.
19. Fryauff, D.J., Baird J.K., Candradikusuma D., Masbar S., Sutamiharja M.A., Leksana B., Sekartuti, Marwoto H., Richie T. and Romzan A. 1997. Survey of in vivo sensitivity to chloroquine by Plasmodium falciparum and P. vivax in Lombok, Indonesia. Am. J. Trop. Med. Hyg., 56(2): 241-244.
20. Fryauff, D.J., Sumawinata, I., Purnomo, Richie, T.L., Tjitra, E., Bangs, M.J., Kadir, A., and Ingkokusumo, G., 1999, In vivo responses to antimalarials by Plasmodium falciparum and Plasmodium vivax from isolated Gag Island off northwest Irian Jaya, Indonesia. Am. J. Trop. Med. Hyg., 60: 542-546.
21. Hoffman, S.L., Campbell, J., Rustama, D., Dimpudus, A.J., and Surumpaet, B., 1987, Pyrimethamine-sulfadoxine still effective against Plasmodium falciparum in Jayapura, Irian Jaya: RI-type resistance in 2 of 18 patients. Trans. R. Soc. Trop. Med. Hyg., 81: 276-277.
22. Hutapea, A.M., 1979. Treatment of falciparum malaria with combined sulfadoxine and pyrimethamine in Jayapura, Indonesia. Lancet, 2: 581
23. Ministry of Health, Directorate General of Communicable Disease Control and Environmental Health. Subdirectorate Malaria. 1998. Recapitulation of Malariometric survey. Tech. Rep. report.
24. Nagesha, H.S., Syafruddin, D., Casey, G.J., Susanti, A.I., Fryhauff, D.J., Reeder, J.C., and Cowman, A.F., 2001, Mutations in the pfmdr1, dhfr and dhps genes of Plasmodium falciparum are associated with in vivo drug resistance in Irian Jaya, Indonesia. Trans. R. Soc. Trop. Med. Hyg., 95 (1): 43-9.
25. Peterson, D.S., Walliker, D., and Wellems, T.E. 1988. Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proc. Natl. Acad. Sci. USA, 85: 9114-9118.
26. Plowe, C.V., Cortese, J.F., Djimde, A., Nwanyanwu, O.C., Watkins, W.M., Winstanley, P. A., Estrada-Franco, J.G., Mollinedo, R.E., Avila, J.C., Cespedes, J.L., Carter, D., and Doumbo, O.K., 1997, Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance. J. Infect. Dis., 176: 1590-1596.
27. Reed, M.B, Saliba, K.S., Caruana, S.R., Kirk, K., and Cowman, A.F., 2000, Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature, 403: 906-909.
28. Reeder, J.C., Rieckmann, K.H., Genton, B., Lorry, K., Wines, B., and Cowman, A.F., 1996, Point mutations in the dihydrofolate reductase and dihydropteroate synthase genes and in vitro susceptibility to pyrimethamine and cycloguanil of Plasmodium falciparum isolates from Papua New Guinea. Am. J. Trop. Med. Hyg., 55: 209-213.
29. R resistant falciparum malaria in indonesia. Lancet, 2: 581.
30. Sirawarapom, W., Sathikul, R., Sirawarapom, R., Yuthavong Y., and Santi, D.V., 1997, Antifolate-resistant mutant of Plasmodium falciparum dihydrofolate reductase. Proc. Natl. Acad. Sci. USA, 94: 1124-1129.
31. Tjitra, E., Gunawan, S., Laihad, F., Marwoto, H., Sulaksono, S., Arjoso, S., Richie, T. L. and Manurung, N. 1997. Evaluation of antimalarial drugs in Indonesia 1981-1995. Bullet. Penelit. Kes., 25, 27-58.
32. Triglia, T., Menting, J.G.T., Wilson, C., and Cowman, A.F., 1997, Mutations of dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum. Proc. Natl. Acad. Sci. USA, 94: 13944-13949.
33. Triglia, T., Wang, P., Sims, P.F.G., Hyde, J.E., and Cowman, A. F., 1998, Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria. Eur. Mol;. Biol. Org. (EMBO) J., 17: 3807-3815.
34. Wang, P., Brooks, R., Sims, P.F.G., and Hyde J.E. 1995, A mutation-specific PCR system to detect sequence variation in the dihydropteroate synthetase gene of Plasmodium falciparum. Mol. Biochem. Parasitol., 71: 115-125.
35. Wang, P., Lee, C.S., Bayoumi, R., Djimde, A., Doumbo, O., Swedberg, G., Dao, L., Mshinda, H., Tanner, M., Watkins, W.M., Sims, P.F.G., and Hyde, J.E., 1997a, Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins. Mol. Biochem. Parasitol., 89: 161-177.
36. Wang, P., Read, M., Sims, P.F. and Hyde, J.E. 1997b, Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization. Mol. Microbiol., 23, 979-986.
37. Wellems, T.E., and Plowe, C.V., 2001, Chloroquine-Resistant malaria. J. Infect. Dis., 184: 770-776
38. Wilson, C.M., Volkman, S.K., Thaitong, S., Martin, R.K., Kyle, D.E., Milhous, W.K., and Wirth, D.F., 1993, Amplification of pfmdr1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand. Mol. Biochem. Parasitol., 57:151-160.
39. Zindrou, S., Dao, L.P., Xuyen, P.T., Dung, N.P., Sy, N.D., Skold, O., and Swedberg G., 1996, Rapid detection of pyrimetamine susceptibility of Plasmodium falciparum by restriction endonuclease digestion of the dihydrofolate reductase gene. Am J. Trop. Med. Hyg., 54: 185-188.