High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance gene pfmdr1

Journal of Infectious Diseases

Volumn 183, Issue 10, 2001, Pages 1535-1538

  Babiker, Hamza A ^a   Pringle, S J ^a   Abdel Muhsin, A ^b   Mackinnon, M ^a   Hunt, P ^a   Walliker, D ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b TROPICAL MEDICINE RESEARCH INSTITUTE   (Sudan)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE;

ALLELE; ARTICLE; DNA POLYMORPHISM; GENE MUTATION; HUMAN; MALARIA; MOLECULAR CLONING; MULTIDRUG RESISTANCE; NONHUMAN; PARASITE ISOLATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SUDAN;

ALLELES; ANIMALS; ANTIMALARIALS; ATP-BINDING CASSETTE TRANSPORTERS; CHLOROQUINE; CLONE CELLS; DRUG RESISTANCE; GENES, PROTOZOAN; HUMANS; LINKAGE DISEQUILIBRIUM; MALARIA, FALCIPARUM; MEMBRANE PROTEINS; MUTATION; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; POLYMORPHISM, GENETIC; PROTOZOAN PROTEINS; SUDAN;

EID: 0035873715     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/320195     Document Type: Article

References (18)

1. Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum
2. Several alleles of the multidrug resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum
3. Complex polymorphisms in a 330 kDa protein are linked to chloroquine resistant P. Falciparum in Southeast Asia and Africa
4. Mutations in the P. Falciparum digestive vacuole transmembrane protein pfcrt- and evidence for their role in chloroquine resistance
5. Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross
6. Chloroquine-resistant Plasmodium falciparum isolates from the Sudan lack two mutations in the pfmdr-1 gene thought to he associated with chloroquine resistance
7. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
8. Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7
9. A molecular marker for chloroquine-resistant falciparum malaria
10. Genetic diversity of the human malaria parasite Plasmodium falciparum in a village in eastern Sudan. II. Drug resistance, molecular karyotypes and the mdr1 genotype in recent field isolates
11. Genetic changes in the population of Plasmodium falciparum population in a Sudanese village over a three-year period
12. Drug response and genetic characterization of P. Falciparum clones recently isolated from a Sudanese village
13. Linkage disequilibrium between two chromosomally distinct loci associated with increased resistance to chloroquine in Plasmodium fakiparum
14. The evolution of multiple drug resistance in malaria parasites
15. Analysis of pfmdr1 and drug susceptibility in fresh isolates of Plasmodium falciparum from sub-Saharan Africa
16. Chloroquine resistance of Plasmodium falciparum: Further evidence for a lack of association with mutations of the pfmdr1 gene
17. Analysis of κ and ω repeats of the cg2 gene and chloroquine susceptibility in isolates of Plasmodium falciparum from sub-Saharan Africa
18. Association of cg2 and pfmdr1 genotype with chloroquine resistance in field samples of Plasmodium falciparum from Nigeria