pfmdr1 Gene mutation and clinical response to chloroquine in Yaounde, Cameroon

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 91, Issue 2, 1997, Pages 210-211

  Basco, Leonardo K ^a,b   Ringwald, Pascal ^a  

^a Laboratoire de Recherche sur le Paludisme Yaounde   (Cameroon)

^b CNRS   (France)

Author keywords

Chloroquine sensitivity; Malaria; pfmdr1 mutation; Plasmodium falciparum

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE; PYRONARIDINE;

ADULT; ARTICLE; CAMEROON; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CODON; CONTROLLED CLINICAL TRIAL; DNA DETERMINATION; GENE MUTATION; GENOTYPE; HUMAN; MALARIA; ORAL DRUG ADMINISTRATION; PLASMODIUM FALCIPARUM; POINT MUTATION; PREDICTION; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

PLASMODIUM FALCIPARUM;

EID: 0030951090     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(97)90227-3     Document Type: Article

References (12)

1. Adagu, I. S., Dias, F., Pinheiro, L., Rombo, L., do Rosario, V. & Warhurst, D. C. (1996). Guinea Bissau: association of chloroquine resistance of Plasmodium falciparum with the Tyr86 allele of the multiple drug-resistance gene Pfmdr1. Transactions of the Royal Society of Tropical Medicine and Hygiene, 90, 90-91.
2. Awad-El-Kariem, F. M., Miles, M. A. & Warhurst, D. C. (1992). Chloroquine-resistant Plasmodium falciparum isolates from the Sudan lack two mutations in the pfmdr1 gene thought to be associated with chloroquine resistance. Transactions of the Royal Society of Tropical Medicine and Hygiene, 86, 587-589.
3. Basco, L. K., Le Bras, J., Rhoades, Z. & Wilson, C. M. (1995). Analysis of pfmdr1 and drug susceptibility in fresh isolates of Plasmodium falciparum from subsaharan Africa. Molecular and Biochemical Parasitology, 74, 157-166.
4. Basco, L. K., Eldin de Pécoulas, P., Le Bras, J. & Wilson, C. M. (1996). Plasmodium falciparum: molecular characterization of multidrug-resistant Cambodian isolates. Experimental Parasitology, 82, 97-103.
5. Cox-Singh, J., Singh, B., Alias, A. & Abdullah, M. S. (1995). Assessment of the association between three pfmdr1 point mutations and chloroquine resistance in vitro of Malaysian Plasmodium falciparum isolates. Transactions of the Royal Society of Tropical Medicine and Hygiene, 89, 436-437.
6. Foote, S. J., Kyle, D. E., Martin, R. K., Oduola, A. M. J., Forsyth, K., Kemp, D. J. & Cowman, A. F. (1990). Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum. Nature, 345, 255-258.
7. Frean, J. A., Awad El Kariem, F. M., Warhurst, D. C. & Miles, M. A. (1992). Rapid detection of pfmdr1 mutations in chloroquine-resistant Plasmodium falciparum malaria by polymerase chain reaction analysis of blood spots. Transactions of the Royal Society of Tropical Medicine and Hygiene, 86, 29-30.
8. Louis, J. P., Hengy, C., Louis, F. J., Gazin, P., Jambou, R., Gardon, J., Fadat, G. & Trebucq, A. (1992). Proposals for a new therapeutic strategy for simple Plasmodium falciparum malaria attacks in Cameroon. Tropical Medicine and Parasitology, 43, 118-120.
9. Ringwald, P., Bickii, J. & Basco, L. K. (1996). Randomised trial of pyronaridine versus chloroquine for acute uncomplicated falciparum malaria in Africa. Lancet, 347, 24-28.
10. Wellems, T. E., Walker-Jonah, A. & Panton, L. J. (1991). Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7. Proceedings of the National Academy of Sciences of the USA, 88, 3382-3386.
11. WHO (1994). Antimalarial drug policies: data requirements, treatment of uncomplicated malaria and management of malaria in pregnancy. Geneva: World Health Organization, mimeo-graphed document WHO/MAL/94.1070.
12. Wilson, C. M., Volkman, S. K., Thaithong, S., Martin, R. K., Kyle, D. E., Milhous, W. K. & Wirth, D. F. (1993). Amplification of pfmdr1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand. Molecular and Biochemical Parasitology, 57, 151-160.