Evidence for selection for the tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum by chloroquine and amodiaquine

Parasitology

Volumn 114, Issue 3, 1997, Pages 205-211

  Duraisingh, M T ^a   Drakeley, C J ^a,b   Muller, O ^b   Bailey, R ^b   Snounou, G ^c   Targett, G A T ^a   Greenwood, B M ^a   Warhurst, D C ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^c NORTHWICK PARK HOSPITAL   (United Kingdom)

Author keywords

allele; amodiaquine; chloroquine; pfmdr1; selection

Indexed keywords

AMODIAQUINE; CHLOROQUINE; TYROSINE;

ALLELE; ARTICLE; BLOOD ANALYSIS; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; GAMBIA; GENETIC SELECTION; GENOTYPE; HUMAN; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ALLELES; AMODIAQUINE; ANIMALS; ANTIMALARIALS; ATP-BINDING CASSETTE TRANSPORTERS; CHILD; CHILD, PRESCHOOL; CHLOROQUINE; CODON; DRUG RESISTANCE; GENES, PROTOZOAN; HUMANS; INFANT; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; SELECTION (GENETICS); TYROSINE;

PLASMODIUM FALCIPARUM;

EID: 0030896558     PISSN: 00311820     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0031182096008487     Document Type: Article

References (32)

1. ADAGU, I. S., WARHURST, D. C., CARUCCI, D. J. & DURAISINGH, M. T. (1995). Pfmdr 1 mutations and chloroquine-resistance in Plasmodium falciparum isolates from Zaria, Nigeria. Transactions of the Royal Society of Tropical Medicine and Hygiene 89, 132.
2. ADAGU, I. S., DIAS, F., PINHEIRO, L., ROMBO, L., DO ROSARIO, V. & WARHURST, D. C. (1996). Guinea Bissau: Association of chloroquine resistance of Plasmodium falciparum with the Tyr-86 allele of the multiple drug-resistance gene Pfmdr 1. Transactions of the Royal Society of Tropical Medicine and Hygiene 90, 90-91.
3. AWAD EI, KARIEM, F. M., MILES, M. A. & WARHURST, D. C. (1992). Chloroquine-resistant Plasmodium falciparum isolates from the Sudan lack two mutations in the pfmdr 1 gene thought to be associated with chloroquine-resistance. Transactions of the Royal Society of Tropical Medicine and Hygiene 86, 587-589.
4. BABIKER, H., RANFORD-CARTWRIGHT, L., SULTAN, A. & WALLIKER, D. (1994). Genetic evidence that RI chloroquine resistance of Plasmodium falciparum is caused by recrudescence of resistance parasites. Transactions of the Royal Society of Tropical Medicine and Hygiene 88, 328-331.
5. BARNES, D. A., FOOTE, S. J., GALATIS, D., KEMP, D. J. & COWMAN, A. F. (1992). Selection for high-level chloroquine resistance results in deamplification of the pfmdr 1 gene and increased sensitivity to mefloquine in Plasmodium falciparum. EMBO Journal 8, 3067-3075.
6. BASCO, L. K., LE BRAS, J., RHOADES, Z. & WILSON, C. M. (1995). Analysis of pfmdr 1 and drug susceptibility in fresh isolates of Plasmodium falciparum from Subsaharan Africa. Molecular and Biochemical Parasitology 74, 157-166.
7. BRANDLING-BENNETT, A. D., OLOO, A. J., WATKINS, M. W., BORIGA, D. A., KARIUKI, D. M. & COLLINS, W. E. (1988). Chloroquine treatment of falciparum malaria in an area of Kenya of intermediate chloroquine resistance. Transactions of the Royal Society of Tropical Medicine and Hygiene 82, 833-837.
8. BRUCE-CHWATT, L. J., CANFIELD, R. H., CLYDE, C. J., PETERS, W. & WERNSDORFER, W. H. (1986). Chemotherapy of Malaria, 2nd edn. WHO, Geneva.
9. CHURCHILL, F. C., PATCHEN, L., CAMPBELL, C., SCHWARTZ, I., NGUYEN-DINH, P. & DICKINSON, C. (1985). Amodiaquine as a pro-drug: the importance of metabolite(s) in the antimalarial effect in humans. Life Science 36, 53 62.
10. CHILDS, G. E., BOUDREAU, E. F., MILHOUS, W. K., WIMONWATTRATTEE, T., POOYINDEE, N., PANG, L. & DAVIDSON, D. E. (1986). A comparison of the in vitro activities of amodiaquine and desethylamodiaquine against isolates of Plasmodium falciparum. American Journal of Tropical Medicine and Hygiene 40, 7-11.
11. COWMAN, A. F., GALATIS, D. & THOMPSON, J. K. (1994). Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr 1 gene and cross-resistance to halofantrine and quinine. Proceedings of the National Academy of Sciences, USA 91, 1143 1147.
12. EKONG, R. M., ROBSON, K. J. H., BAKER, D. A. & WARHURST, D. C. (1993). Transcripts of the multidrug resistance genes in chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum. Parasitology 106, 107-115.
13. FITCH, C. D. & WARHURST, D. C. (1986). The mode of action of chloroquine and related malarial schizonticides. Parasitology Today 2, 329-334.
14. FOOTE, S. J., THOMPSON, J. K., COWMAN, A. F. & KEMP, D. J. (1989). Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of Plasmodium falciparum. Cell 57, 921-930.
15. FOOTE, S. J., KYLE, D. E., MARTIN, R. K., ODUOLA, A. M. J., FORSYTH, K., KEMP, D. J. & COWMAN, A. F. (1990). Several alleles of the multidrug resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum. Nature, London 345, 255-258.
16. FREAN, J. A., AWAD EL KARIEM, F. M., WARHURST, D. C. & MILES, M. A. (1992). Rapid detection of pfmdr 1 mutations in chloroquine-resistant Plasmodium falciparum malaria by polymerase chain reaction analysis of blood spots. Transactions of the Royal Society of Tropical Medicine and Hygiene 86, 29-30.
17. HELLGREN, U., KIHAMIA, C. M., MAHIKWANO, L. F., BJORKMAN, A., ERIKSSON, O. & ROMBO, L. (1989). Response of Plasmodium falciparum to chloroquine treatment: relation to whole blood concentrations of chloroquine and desethylchloroquine. Bulletin of the World Health Organization 67, 197-202.
18. HIGGINS, C. F. (1992). ABC transporters: from microorganisms to man. Annual Review of Cell Biology 8, 67-113.
19. MENON, A., SNOW, R. W., OTOO, L. & GREENWOOD, B. M. (1987). Decline in the sensitivity of Plasmodium falciparum to chloroquine in the Gambia. Lancet 2, 1029-1039.
20. MULLER, O., VAN HENSBROEK, M. B., JAFFAR, S., DRAKELEY, C., OKORIE, C., JOOF, D., PINDER, M. & GREENWOOD, B. (1996). Randomised trial of chloroquine, amodiaquine and pyrimethamine-sulfadoxine in Gambian children with uncomplicated malaria. Tropical Medicine and International Health 1, 124-132.
21. PEEL, S. A., BRIGHT, P., YOUNT, B., HANDY, J. & BARIC, R. S. (1994). A strong association between mefloquine and halofantrine resistance and amplification, overexpression, and mutation in the P-glycoprotein gene homology (pfmdr) of Plasmodium falciparum in vitro. American Journal of Tropical Medicine and Hygiene 51, 648-658.
22. PUSSARD, E., VERDIER, F., FAURISSON, F., SCHERMANN, J., LE BRAS, J. & BLAYO, M. C. (1987). Disposition of monodesethylamodiaquine after a single oral dose of amodiaquine, and three regimens for prophylaxis against Plasmodium falciparum malaria. European Journal of Clinical Pharmacology 33, 409-414.
23. PUSSARD, E. & VERDIER, F. (1994). Antimalarial 4-aminoquinolines: mode of action and pharmacokinetics. Fundamentals of Clinical Pharmacology 3, 1-17.
24. ROMBO, L., BJORKMAN, A., SEGO, E. & ERICSSON, O. (1986). Whole blood concentrations of chloroquine and desethylchloroquine during and after treatment of adult patients infected with Plasmodium vivax, Plasmodium ovale or Plasmodium malariae. Transactions of the Royal Society of Tropical Medicine and Hygiene 80, 763-766.
25. VAN ES, H. H. G., KARCZ, S., CHU, F., COWMAN, A. F., VIDAL, s., GROS, P. & SCHURR, E. (1994). Expression of the plasmodial pfmdr 1 gene in mammalian cells is associated with increased susceptibility to chloroquine. Molecular and Cellular Biology 14, 2419-2428.
26. VIRIYAKOSOL, S., SIRIPOON, N., PETCHARAPIRAT, C., PETCHARAPIRAT, P., JARRA, W., THAITHONG, S., BROWN, K. N. & SNOUNOU, G. (1995). Genotyping of Plasmodium falciparum isolates by the polymerase chain reaction and potential uses in epidemiological studies. Bulletin of the World Health Organization 93, 85-95.
27. VOLKMAN, S. K., WOODCOCK, S., COWMAN, A. F. & WIRTH, D. F. (1995). Functional complementation of the ste6 gene of Saccharomyces cerevisiae with the pfmdr 1 gene of Plasmodium falciparum. Proceedings of the National Academy of Sciences, USA 92, 8921-8925.
28. WATKINS, W. M., SPENCER, H. C., KARIUKI, D., SIXSMITH, D., BORIGA, D. & KIPINGOR, T. (1984). Effectiveness of amodiaquine as treatment for chloroquine resistance Plasmodium falciparum infections in Kenya. Lancet 1, 8373, 357-359.
29. WATKINS, W. M. & MOSOBO, M. (1993). Treatment of falciparum malaria with pyrimethamine-sulfadoxine: selective pressure for resistance is a function of long elimination half-life. Transactions of the Royal Society of Tropical Medicine and Hygiene 87, 75-78.
30. WERNSDORFER, W. H. (1994). Epidemiology of drug-resistance in malaria. Acta tropica 56, 143-156.
31. WILSON, C. M., VOLKMAN, S. K., THAITHONG, S., MARTIN, R. K., KYLE, D. E., MILHOUS, W. K. & WIRTH, D. F. (1993). Amplification of pfmdr 1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand. Molecular and Biochemical Parasitology 57, 151-160.
32. WINSTANLEY, P. A., SIMOOYA, O., KOFI-EKUE, J. M., WALKER, O., SALAKO, L. A., EDWARDS, G., ORME, M. L. E. & BRECKENRIDGE, A. M. (1990). The disposition of amodiaquine in Zambians and Nigerians with malaria. British Journal of Clinical Pharmacology 29, 695-701.