Analysis of the key pfcrt point mutation and in vitro and in vivo response to chloroquine in Yaoundé, Cameroon

Journal of Infectious Diseases

Volumn 183, Issue 12, 2001, Pages 1828-1831

  Basco, Leonardo K ^a   Ringwald, Pascal ^a  

^a WORLD HEALTH ORGANIZATION   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; GENE PRODUCT; PROTEIN PFCRT; UNCLASSIFIED DRUG;

ARTICLE; CAMEROON; CHILD; CODON; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE MUTATION; GENETIC ANALYSIS; GENETIC POLYMORPHISM; HUMAN; MAJOR CLINICAL STUDY; MALARIA; PHENOTYPE; PLASMODIUM FALCIPARUM; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT;

ADOLESCENT; ADULT; ANIMALS; ANTIMALARIALS; CAMEROON; CHILD; CHLOROQUINE; CODON; DRUG RESISTANCE; FEMALE; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PHENOTYPE; PLASMODIUM FALCIPARUM; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROTOZOAN PROTEINS; SENSITIVITY AND SPECIFICITY;

EID: 0035876910     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/320726     Document Type: Article

References (15)

1. Chloroquine uptake by Plasmodium falciparum-infected human erythrocytes during in vitro culture and its relationship to chloroquine resistance
2. Energy dependence of chloroquine accumulation and chloroquine efflux in Plasmodium falciparum
3. Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum
4. Amplification of pfmdr1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand
5. Chloroquine resistance not linked to mdr-like genes in Plasmodium falciparum cross
6. Complex polymorphisms in an ∼330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa
7. Chloroquine resistance in Plasmodium falciparum and polymorphism of cg2 gene
8. Molecular epidemiology of malaria in Yaoundé, Cameroon V. Analysis of the omega repetitive region of the Plasmodium falciparum cg2 gene and chloroquine resistance
9. Point mutations in the Plasmodium falciparum cg2 gene, polymorphism of the kappa repeat region, and their relationship with chloroquine resistance
10. Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum
11. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
12. A molecular marker for chloroquine-resistant falciparum malaria
13. Molecular epidemiology of malaria in Yaoundé, Cameroon. VIII. Multiple Plasmodium falciparum infections in symptomatic patients
14. In vitro activity of antimalarials against clinical isolates of Plasmodium falciparum in Yaoundé, Cameroon