No association between bipolar affective disorder and a serotonin receptor (5-HT2A) polymorphism

Psychiatry Research

Volumn 70, Issue 2, 1997, Pages 65-69

  Mahieu, Brigitte ^a   Souery, Daniel ^a   Lipp, Olivier ^a   Mendelbaum, Karin ^a   Verheyen, Geert ^c   De Maertelaer, Viviane ^b   Van Broeckhoven, Christine ^c   Mendlewicz, Julien ^a  

^a ERASME HOSPITAL   (Belgium)

^b FREE UNIVERSITY OF BRUSSELS   (Belgium)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

Allelic association; Candidate gene; Serotonin transmission

Indexed keywords

DNA; SEROTONIN 2A RECEPTOR;

ADULT; ARTICLE; CASE CONTROL STUDY; CHROMOSOME 13Q; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MANIC DEPRESSIVE PSYCHOSIS; PRIORITY JOURNAL; RECEPTOR GENE;

ADULT; AGED; ALLELES; BIPOLAR DISORDER; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 13; FEMALE; GENOTYPE; HETEROZYGOTE DETECTION; HUMANS; MALE; MIDDLE AGED; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; RISK FACTORS;

EID: 0031010498     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1781(97)03028-X     Document Type: Article

References (20)

1. Arango, V., Underwood, M.D. and Mann, J.J. (1992) Alterations in monoamine receptors in the brain of suicide victims. J Clin Psychopharmacol 12, 8S-12S.
2. 3H-LSD) in the blood platelets of depressed patients. Life Sci 44, 725-734.
3. Biegon, A., Weizman, A., Karp, L., Ram, A., Tiano, S. and Wolff, M. (1987) Serotonin 5-HT2 receptor binding on blood platelets - a peripheral marker for depression. Life Sci 41, 2485-2492.
4. Charney, D.S. and Delgado, P.L. (1992) Current concept of the role of serotonin function in depression and anxiety. In: Langer, S.Z., Brunello, N., Racagni, G. and Mendlewicz, J. (Eds.), Serotonin Receptor Subtypes: Pharmacological Significance and Clinical Implication. Karger series, Basel, pp. 89-104.
5. Cowen, P.J. (1990) A role for 5-HT in the action of antidepressant drugs. Pharmacol Ther 46, 43-51.
6. Dean, J., Dean, A., Burton, A. and Dicker, R. (1991) Epi Info Version 5.01a. Centers for Disease Control, Atlanta.
7. Endicott, J. and Spitzer, R.L. (1978) A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 35, 837-862.
8. Ghanshyam, N.P., Subhash, C.P., Yogesh, D., Rajiv, P.S., Philip, G.J. and John, M.D. (1995) Platelet serotonin-2A receptors: a potential biological marker for suicidal behavior. Am J Psychiatry 152, 850-855.
9. Gutiérrez, B., Arranz, M., Fananas, L., Vallès, V., Guillamat, R., van Os, J. and Collier, D. (1995) 5HT2A receptor gene and bipolar affective disorder. Lancet 346, 969.
10. Leysen, J.E. and Pauwels, P. (1990) 5-HT2 receptors, role and regulation, the neuropharmacology of serotonin. Ann NY Acad Sci 600, 183-193.
11. Leysen, J.E. (1992) 5-HT2 receptors: location, pharmacological, pathological and physiological role. In: Langer, S.Z., Brunello, N., Racagni, G. and Mendlewicz, J. (Eds.), Serotonin Receptor Subtypes: Pharmacological Significance and Clinical Implication. Karger series, Basel, pp. 31-43.
12. Maes, M. and Meltzer, H.Y. (1995) The serotonin hypothesis of major depression. In: Bloom, F.E. and Kupfer, D.J. (Eds.), Psychopharmacology: The Fourth Generation of Progress. Raven Press, New York, p. 940.
13. Mendlewicz, J. (1994) The search for a manic depressive gene: from classical to molecular genetics. Prog Brain Res 100, 225-259.
14. Sharpley, A.L., Gregory, C.A., Solomon, R.A. and Cowen, P.J. (1990) Slow wave sleep and 5-HT2 receptor sensitivity during maintenance tricyclic antidepressant treatment. J Affect Disord 19, 273-277.
15. Souery, D., Papadimitriou, G.N. and Mendlewicz, J. (1996) New genetic approaches in affective disorders, In: Papadimitriou, G.N. and Mendlewicz, J. (Eds.), Genetics of Mental Disorders Part II: Clinical Issues. Baillière's Clinical Psychiatry, International Practice and Research, Bailliere Tindall, London. Vol. 2, No 1, pp. 1-13.
16. Spitzer, R.L., Endicott, J. and Robins, E. (1978) Research diagnostic criteria: rationale and reliability. Arch Gen Psychiatry 35, 773-782.
17. Staner, L., Kempenaers, C., Simonnet, M.P., Fransolet, L. and Mendlewicz, J. (1992) 5-HT2 receptor antagonism and slow wave sleep in major depression. Acta Psychiatr Scand 86, 133-137.
18. Yates, M., Leake, A., Candy, J.M., Fairbairn, A.F., McKeith, I.G. and Ferrier, I.N. (1990) 5-HT2 receptor changes in major depression. Biol Psychiatry 27, 489-96.
19. A receptor subunit genes as candidate genes for bipolar affective disorder - an association analysis. Psychiatr Genet 2, 239-247.
20. Warren, J.T. Jr., Peacock, M.L., Rodriguez, L.C. and Fink, J.K. (1993) An M spI polymorphism in the human serotonin receptor gene (HTR2): detection by DGGE and RFLP analysis. Hum Mol Genet 3, 338.