An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a human population isolate from Colombia

Neuroscience Letters

Volumn 292, Issue 3, 2000, Pages 199-202

  Ospina Duque, Jorge ^a   Duque, Constanza ^a   Carvajal Carmona, Luis ^b   Ortiz Barrientos, Daniel ^a   Soto, Ivan ^a   Pineda, Nicolas ^a   Cuartas, Mauricio ^a   Calle, Jorge ^a   Lopez, Carlos ^a   Ochoa, Luis ^a   Garcia, Jenny ^a   Gomez, Juliana ^a   Agudelo, Angela ^a   Lozano, Maria ^a   Montoya, Gabriel ^a   Ospina, Angelica ^a   Lopez, Maria ^a   Gallo, Aurora ^a   Miranda, Ana ^a   Serna, Lina ^a   Montoya, Patricia ^a   Palacio, Carlos ^a   Bedoya, Gabriel ^a   McCarthy, Mark ^c   Reus, Victor ^d   Freimer, Nelson ^d   Ruiz Linares, Andres ^a,b   more..

^a UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bipolar mood disorder; Population isolates; Serotonin transporter

Indexed keywords

SEROTONIN TRANSPORTER;

ARTICLE; COLOMBIA; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MANIC DEPRESSIVE PSYCHOSIS; MENTAL DISEASE; POPULATION RESEARCH; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM;

AGE OF ONSET; ALLELES; BIPOLAR DISORDER; CARRIER PROTEINS; COLOMBIA; GENE FREQUENCY; GENETICS, POPULATION; HUMAN; LINKAGE (GENETICS); MEMBRANE GLYCOPROTEINS; ODDS RATIO; POLYMORPHISM (GENETICS); PROMOTER REGIONS (GENETICS); SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0034644955     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01464-6     Document Type: Article

References (18)

1. Reus V.I., Freimer N.B. Understanding the genetic basis of mood disorders: where do we stand? [comment] Am. J. Hum. Genet. 60:1997;1283-1288.
2. DeLisi L.E., Crow T.J. Chromosome Workshops 1998: current state of psychiatric linkage. Am. J. Med. Genet. 88:1999;215-218.
3. Owen M.J., Cardno A.G., O'Donovan M.C. Psychiatric genetics: back to the future. Mol. Psychiatry. 5:2000;22-31.
4. Heils A., Teufel A., Petri S., Stober G., Riederer P., Bengel D., Lesch K.P. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 66:1996;2621-2624.
5. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., Benjamin J., Muller C.R., Hamer D.H., Murphy D.L. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. [see comments] Science. 274:1996;1527-1531.
6. Collier D.A., Arranz M.J., Sham P., Battersby S., Vallada H., Gill P., Aitchison K.J., Sodhi M., Li T., Roberts G.W., Smith B., Morton J., Murray R.M., Smith D., Kirov G. The serotonin transporter is a potential susceptibility factor for bipolar affective disorder. NeuroReport. 7:1996;1675-1679.
7. Gutierrez B., Arranz M.J., Collier D.A., Valles V., Guillamat R., Bertranpetit J., Murray R.M., Fanas L. Serotonin transporter gene and risk for bipolar affective disorder: an association study in Spanish population. Biol. Psychiatry. 43:1998;843-847.
8. Ohara K., Nagai M., Tsukamoto T., Tani K., Suzuki Y., Ohara K. Functional polymorphism in the serotonin transporter promoter at the SLC6A4 locus and mood disorders. Biol. Psychiatry. 44:1998;550-554.
9. Mendes D.O. Jr, Otto P.A., Vallada H., Lauriano V., Elkis H., Lafer B., Vasquez L., Gentil V., Passos-Bueno M.R., Zatz M. Analysis of a novel functional polymorphism within the promoter region of the serotonin transporter gene (5-HTT) in Brazilian patients affected by bipolar disorder and schizophrenia. Am. J. Med. Genet. 81:1998;225-227.
10. Lendon C.L., Martinez A., Behrens I.M., Kosik K.S., Madrigal L., Norton J., Neuman R., Myers A., Busfield F., Wragg M., Arcos M., Arango Viana J.C., Ossa J., Ruiz A., Goate A.M., Lopera F. E280A PS-1 mutation causes Alzheimer's disease but age of onset is not modified by ApoE alleles. Hum. Mutat. 10:1997;186-195.
11. Lopera F., Ardilla A., Martinez A., Madrigal L., Arango-Viana J.C., Lemere C.A., Arango-Lasprilla J.C., Hincapie L., Arcos-Burgos M., Ossa J.E., Behrens I.M., Norton J., Lendon C., Goate A.M., Ruiz-Linares A., Rosselli M., Kosik K.S. Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation. JAMA. 277:1997;793-799.
12. Nurnberger J.I. Jr, Blehar M.C., Kaufmann C.A., York-Cooler C., Simpson S.G., Harkavy-Friedman J., Severe J.B., Malaspina D., Reich T. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch. Gen. Psychiatry. 51:1994;849-859.
13. Gelernter J., Cubells J.F., Kidd J.R., Pakstis A.J., Kidd K.K. Population studies of polymorphisms of the serotonin transporter protein gene. Am. J. Med. Genet. 88:1999;61-66.
14. Bellivier F., Henry C., Szoke A., Schurhoff F., Nosten-Bertrand M., Feingold J., Launay J.M., Leboyer M., Laplanche J.L. Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression. Neurosci. Lett. 255:1998;143-146.
15. Kunugi H., Hattori M., Kato T., Tatsumi M., Sakai T., Sasaki T., Hirose T., Nanko S. Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder. Mol. Psychiatry. 2:1997;457-462.
16. Furlong R.A., Ho L., Walsh C., Rubinsztein J.S., Jain S., Paykel E.S., Easton D.F., Rubinsztein D.C. Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. Am. J. Med. Genet. 81:1998;58-63.
17. Ho L.W., Furlong R.A., Rubinsztein J.S., Walsh C., Paykel E.S., Rubinsztein D.C. Genetic associations with clinical characteristics in bipolar affective disorder and recurrent unipolar depressive disorder. Am. J. Med. Genet. 96:2000;36-42.
18. Nakamura M., Ueno S., Sano A., Tanabe H. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol. Psychiatry. 5:2000;32-38.