Analysis of a novel functional polymorphism within the promoter region of the serotonin transporter gene (5-HTT) in Brazilian patients affected by bipolar disorder and schizophrenia

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 81, Issue 3, 1998, Pages 225-227

  Mendes De Oliveira, João R ^a,b   Otto, Paulo A ^a   Vallada, Homero ^a   Lauriano, Valéria ^a   Elkis, Helio ^a   Lafer, Beny ^a   Vasquez, Luciana ^a   Gentil, Valentim ^a   Passos Bueno, M Rita ^a   Zatz, Mayana ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

Author keywords

Bipolar depression; Genetics; Schizophrenia; Serotonin transporter

Indexed keywords

SEROTONIN TRANSPORTER;

ARTICLE; BRAZIL; CONTROLLED STUDY; DNA POLYMORPHISM; GENE FREQUENCY; GENETIC ANALYSIS; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MANIC DEPRESSIVE PSYCHOSIS; PRIORITY JOURNAL; PROMOTER REGION; SCHIZOPHRENIA;

BIPOLAR DISORDER; BRAZIL; CARRIER PROTEINS; GENE FREQUENCY; GENES; GENOTYPE; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); SCHIZOPHRENIA; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 17944397930     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19980508)81:3<225::AID-AJMG4>3.0.CO;2-V     Document Type: Article

References (19)

1. Altemus M, Murphy DL, Greenberg B, et al. (1996): Intact Coding Region of the Serotonin Transporter Gene in Obssesive-Compulsive disorder. Am J Med Genet 67:409-411.
2. Craddock N, Rees M, Norton N et al. (1996): Association between bipolar disorder and the VNTR polymorphism in intron 2 of the human serotonin transporter (hSERT). Psychiatr Genetics 6:147.
3. Collier DA, Stöberg G, Li T et al. (1996): A novel funciotnal polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Molecular Psychiatry 1:453-460.
4. Gelernter J, Pakstis AJ, Kidd KK (1995): Linkage mapping of the serotonin transporter protein gene SCL 6A4 on chromosome 17. Human Genet 95:677-680.
5. Gurwitz, D (1997): Complex traits, complex answers. Molecular Psychiatry 2:89-90.
6. Heils A, Teufel A, Petri S, et al. (1995): Functional promoter and polyadenilation site mapping of the human serotonin (5-HT) transporter gene. J Neural Transm[Gen Sect] 102:247-254.
7. Heils A, Teufel A, Petri S, et al. (1996): Allelic Variation of Human Serotonin Transporter Gene Expression. J Neurochem 66:2621-2624.
8. Joyce J.N., Shane A, Lexow N, et al. (1993): Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neupsychopharmacology 8:315-336.
9. Lesch KP, Wolozin BL,Estler HC, et al. (1993): Isolation of a cDNA encoding the human brain serotonin transporter. J Neural Transm 91:67-72.
10. Lesch KP, Balling U, Gross J, et al. (1994): Organization of the human serotonin transporter gene. J Neural Transm 95:157-162.
11. Lesch KP, Gross J, Franzek E, et al. (1995): Primary Structure of the Serotonin Transporter in Unipolar Depression and Bipolar Disorder. Biol Psychiatry 37:215-223.
12. Lesch KP, Bengel D, Heils A, et al. (1996): Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transportet Gene Regulatory Region. Science 274:1527-1531.
13. Meltzer H, Arora R, Baber R, et al. (1981): Serotonin uptake in blood platelets of psychiatric patients. Arch Gen Psychiatry 38:1322-1329.
14. Ogilvie AD, Battersby S, Bubb VJ, et al. (1996): Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 347:731-733.
15. Okubo Y, Suhara T, Suzuki K, et al. (1997): Decreased prefrontal dopamine D1 rerceptors in schizophrenia revealed by PET. Nature 385:634-636.
16. Ramamoorthy S, Bauman AL, Moore KR, et al. (1993): Antidepressant- and cocain-sensitive human serotonin transporter: Molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 90:2542-2546.
17. Risch SC, Nemeroff CB (1992). Neurochemical alterations of serotonergic neuronal systems in depression. J. Clin. Psychiatr 1992; 53 (Supp):3-7
18. Seeeman P, Lee T, Chau-Wong M, et al. (1976): Antipsychotic drug doses and neuroleptic/dopamine receptors. Nature 261:717-719.
19. Stahl S, Woo D, Mefford I, et al. (1983): Hyperserotonin and platelet serotonin uptake in schizophrenia and affective disorder. Am. J. Psychiatry 140:26-31.