Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways

Molecular Psychiatry

Volumn 4, Issue 4, 1999, Pages 389-392

  Frisch, A ^a,b   Postilnick, D ^c   Rockah, R ^a,b   Michaelovsky, E ^a,b   Postilnick, S ^d   Birman, E ^c   Laor, N ^b,e   Rauchverger, B ^c   Kreinin, A ^d   Poyurovsky, M ^d   Schneidman, M ^d   Modai, I ^b,c   Weizman, R ^b,e  

^a RABIN MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c SHA'AR MENASHE MENTAL HEALTH CENTER   (Israel)

^d Hacarmel Medical Center   (Israel)

^e SHALVATA MENTAL HEALTH CENTER   (Israel)

Author keywords

Catechol O methyl transferase (COMT); Dopamine D4 receptor (DRD4); Dopamine transporter (DAT1); Major depressive disorder (MDD); Serotonin receptor 2A (HTR2A); Serotonin receptor 2C (HTR2C); Serotonin transporter promoter region (5 HTTLPR); Tryptophan hydroxylase (TPH)

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE; DOPAMINE 4 RECEPTOR; DOPAMINE TRANSPORTER; NEUROTRANSMITTER; SEROTONIN; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN TRANSPORTER; TRYPTOPHAN HYDROXYLASE;

ALLELE; ARTICLE; CONTROLLED STUDY; DEPRESSION; DOPAMINERGIC SYSTEM; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MENTAL DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; SEROTONINERGIC SYSTEM; STATISTICS;

EID: 0032871864     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000536     Document Type: Article

References (25)

1. Kaplan HJ, Sadock BJ, Grebb JA. Synopsis of Psychiatry, 7th edn. Williams & Wilkins: Baltimore, 1994, pp 516-555.
2. Kendler KS, Walters EE, Truett KR, Heath A, Neale MC, Martin NG et al. Sources of individual differences in depressive symptoms: analysis of two samples of twins and their families. Am J Psychiatry 1994; 151: 1605-1614.
3. Maes M, Meltzer HY. The serotonin hypothesis of major depression. In: Bloom FE, Kupfer DJ (eds). Psychopharmacology; The Fourth Generation of Progress. Raven Press: New York, 1995, pp 933-944.
4. Willner P. Dopamine mechanisms in depression and mania. In: Bloom FE, Kupfer DJ (eds). Psychopharmacology: The Fourth Generation of Progress. Raven Press: New York, 1995, pp 921-931.
5. Kunugi H, Hattori M, Kato T, Tatsumi M, Saki T, Sasaki T et al. Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar effective disorder. Mol Psychiatry 1997; 2: 457-462.
6. Rees M, Norton N, Jones I, MacCandless F, Scourfield J, Holmans P et al. Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT). Mol Psychiatry 1997; 2: 398-402.
7. Furlong RA, Ho L, Walsh C, Rubinsztein JS, Jain S, Paykel ES et al. Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. Am J Med Genet 1998; 81: 58-63.
8. Hoehe MR, Wendel B, Grunewald I, Chiaroni P, Levy N, Morris-Rosendahl D et al. Serotonin transporter (5-HTT) gene polymorphisms are not associated with susceptibility to mood disorders. Am J Med Genet 1998; 81: 1-3.
9. Cellier DA, Stober G, Li T, Heils A, Catalano M, Di Bella De et al. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1996; 1: 453-460.
10. Zhang H-Y, Ishigaki T, Tani K, Chen K, Chen Shih J, Miyasato K et al. Serotonin 2A receptor gene polymorphism in mood disorders. Biol Psychiatry 1997; 41: 768-773.
11. Furlong RA, Ho L, Rubinsztein JS, Walsh C, Paykel ES, Rubinsztein DC. No association of the tryptophan hydroxylase gene with bipolar affective disorder, unipolar affective disorder, or suicidal behavior major affective disorder. Am J Med Genet 1998; 81: 245-247.
12. Manki H, Kanba S, Muramatsu T, Higuchi S, Suzuki E, Matsushita S et al. Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders. J Affect Dis 1996; 40: 7-13.
13. Oruc L, Verheyen GR, Furac I, Jakovljevic M, Ivezic S, Raeymaekers P et al. Analysis of the tyrosine hydroxylase and dopamine D4 receptor genes in a Croalian sample of bipolar I and unipolar patients. Am J Med Genet 1997; 74: 176-178.
14. Ohara K, Nagai M, Suzuki Y, Ohara K. Low activity allele of catechol-O-methyltransferase gene and Japanese unipolar depression. Neuroreport 1998; 9: 1305-1308.
15. Owen MJ, Holmans P, McGuffin P. Association studies in psychiatric genetics. Mol Psychiatry 1997; 2: 270-273.
16. Endicott J, Spitzer RL. Use of research diagnostic criteria and the Schedule for Affective Disorders and Schizophrenia. Am J Psychiatry 1984; 136: 266-267.
17. First BM, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for Axis I DSM-IV Disorders-Patient edn (SCID-P), version 2.0 [Hebrew translation]. Biometrics Research Department, New York State Psychiatric Institute: New York, 1995.
18. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from nucleated cells. NAR 1988; 16: 1215.
19. Nielsen DA, Dean M, Goldman D. Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11 using an intronic conformational polymorphism. Am J Hum Genet 1992; 51: 1366-1371.
20. Warren JT Jr, Peacock ML, Rodriguez LC, Fink JK. An Mspl polymorphism in the human serotonin receptor gene (HTR2): detection by DGGE and RFLP analysis. Hum Mol Genet 1993; 2: 338.
21. Lappalainen J, Zhang L, Dean M, Oz M, Ozaki N, Yu D-H et al. Identification, expression and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2C receptor gene (HTR2C). Genomics 1995; 27: 274-279.
22. Lesch KP, Bengel D, Heils A, Sabol SZ, Groenberg BD, Patri S et al. Association of anxiety related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527-1531.
23. Lichter JB, Barr C, Kennedy J, Van Tol HH, Kidd KK, Livak KJ. A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Hum Mol Genet 1993; 2: 767-773.
24. Vandenbergh DJ, Perisco AM, Hawkins AL, Griffin CA, Li X, Jabs EW et al. Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics 1992; 14: 1104-1106.
25. Lachman HM, Morrow B, Shprinzen R et al. Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome. Am J Med Genet (Neuropsych Genet) 1996; 76: 468-472.