Serotonin-2C and serotonin-1A receptor genes are not associated with psychotic symptomatology of mood disorders

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 96, Issue 2, 2000, Pages 161-166

  Serretti, Alessandro ^a   Lilli, Roberta ^a   Lorenzi, Cristina ^a   Lattuada, Enrico ^a   Smeraldi, Enrico ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Bipolar disorder; Depressive disorder; Phenotype; Serotonin; Serotonin receptors

Indexed keywords

SEROTONIN 1A RECEPTOR; SEROTONIN 2C RECEPTOR;

AFFECTIVE NEUROSIS; ALLELE; ARTICLE; DISEASE ASSOCIATION; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; PATHOPHYSIOLOGY; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; SYMPTOMATOLOGY;

ADULT; FEMALE; HUMANS; LINKAGE (GENETICS); MALE; MIDDLE AGED; MOOD DISORDERS; PHENOTYPE; POLYMORPHISM, GENETIC; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEVERITY OF ILLNESS INDEX;

EID: 0034599554     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(20000403)96:2<161::AID-AJMG7>3.0.CO;2-9     Document Type: Article

References (78)

1. Abi-Saab WM, Bubser M, Roth RH, Deutch AY. 1999. 5HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex. Neuropsycopharmacology 20:92-96.
2. American Psychiatric Association. 1994. Diagnostic and statistical manual of mental disorders, 4th ed. Washington, DC: American Psychiatric Association.
3. Andreasen NC, Arndt S, Alliger R, Miller D, Flaum M. 1995. Symptoms of schizophrenia. Methods, meanings, and mechanisms. Arch Gen Psychiatry 52:341-351.
4. Artigas F, Perez V, Alvarez E. 1994. Pindolol induces a rapid improvement of depressed patients treated with serotonin reuptake inhibitors. Arch Gen Psychiatry 51:248-251.
5. Artigas F, Romero L, de Montigny C, Blier P. 1996. Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists. Trends Neurosci 19:378-383.
6. Baez M, Kursar JD, Helton LA, Wainscott DB, Nelson DL. 1995. Molecular biology of serotonin receptors. Obesity Res 3:441S-447S.
7. Barbujani G, Sokal RR. 1991. Genetic population structure of Italy. I. Geographic patterns of gene frequencies. Hum Biol 63:253-272.
8. Benkelfat C. 1993. Serotoninergic mechanisms in psychiatric disorders: new research tools, new ideas. Int Clin Psychopharmacol 8(suppl):53-56.
9. Bradley C, Blakely R. 1997. Alternative splicing of the human serotonin transporter gene. J Neurochem 69:1356-1367.
10. Brett PM, Curtis D, Robertson MM, Gurling HM. 1995. Exclusion of the 5-HT1A serotonin neuroreceptor and tryptophan oxygenase genes in a large British kindred multiply affected with Tourette's syndrome, chronic motor tics, and obsessive-compulsive behavior. Am J Psychiatry 152:437-440.
11. Burke JG, Murphy BM, Bray JC, Walsh D, Kendler KS. 1996. Clinical similarities in siblings with schizophrenia. Am J Med Gen 67:239-243.
12. Burns CM, Chu H, Rueter SM, Hutchinson LK, Canton H, Sanders-Bush E, Emeson RB. 1997. Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature 387:303-308.
13. Cavallini MC, Di Bella D, Pasquale L, Henin M, Bellodi L. 1998. 5HT2C CYS23/SER23 polymorphism is not associated with obsessive-compulsive disorder. Psychiatry Res 77:97-104.
14. Chua SE, Wright IC, Poline JB, Liddle PF, Murray RM, Frackowiak RS, Friston KJ, McGuire PK. 1997. Grey matter correlates of syndromes in schizophrenia. A semi-automated analysis of structural magnetic resonance images. Br J Psychiatry 170:406-410.
15. Cloninger C. 1994. Turning point in the design of linkage studies of schizophrenia. Am J Med Gen 54:83-92.
16. Cloninger C, Adolfsson R, Svrakic N. 1996. Mapping genes for human personality. Nat Genet 12:3-4.
17. Cohen J. 1988. Statistical power analysis for the behavioral sciences. Hillsdale, N.J.: Lawrence Erlbaum.
18. Comings D. 1997. Polygenic inheritance in psychiatric disorders. In: Blum K, Noble EP, editors. Handbook of psychiatric genetics. Boca Raton: CRC Press. p 235-260.
19. Coryell W, Winokur G, Shea T, Maser J, Endicott J, Akiskal H. 1994. The long-term stability of depressive subtypes. Am J Psychiatry 151:199-204.
20. Cowen PJ. 1993. Serotonin receptor subtypes in depression: evidence from studies in neuroendocrine regulation. Clin Neuropharmacol 16:S6-18.
21. Curtis D, Brynjolfsson J, Petursson H, Holmes DS, Sherrington R, Brett P, Rifkin L, Murphy P, Moloney E, Holmes S, et al. 1993. Segregation and linkage analysis in five manic depression pedigrees excludes the 5HT1a receptor gene (HTR1A). Ann Hum Genet 57:27-39.
22. De Montigny C, Chaput Y, Blier P. 1993. Classical and novel targets for antidepressant drugs: new pharmacological approaches to the therapy of depressive disorders. Int Acad Biomed Drug Res 5:8-17.
23. Endicott J, Spitzer R. 1978. A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 35:837-844.
24. Erdmann J, Shimron-Abarbanell D, Cichon S, Albus M, Maier W, Lichtermann D, Minges J, Reuner U. Franzek E, Ertl MA, et al. 1995. Systematic screening for mutations in the promoter and the coding region of the 5-HT1A gene. Am J Med Gen 60:393-399.
25. Fargin A, Raymond JR, Lohse MJ, Kobilka BK, Caron MG, Lefkowitz RJ. 1988. The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor. Nature 335:358-360.
26. Fuciarelli M, Vienna A, Paba E, Bastianini A, Sansonetti B, Capucci E, Destefano GF. 1997. PI, GC, HP, and TF serum protein polymorphisms in Siena, Tuscany, Italy, with a review of data for Italy. Am J Hum Biol 9:629-646.
27. Gasparini P, Estivill X, Volpini V, Totaro A, Castellvi-Bel S, Govea N, Mila M, Della Monica M, Ventruto V. et al. 1997. Linkage of DFNB1 to non-syndromic neurosensory autosomal-recessive deafness in Mediterranean families. Eur J Hum Genet 5:83-88.
28. Gilliam TC, Freimer NB, Kaufmann CA, Powchik PP, Bassett AS, Bengtsson U, Wasmuth JJ. 1989. Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia. Genomics 5:940-944.
29. Ginsburg B, Werick T, Escobar J, Kugelmass S. 1996. Molecular genetics of psychopathologies: a search for simple answers to complex problems. Behav Genet 26:325-333.
30. Goldman D. 1995. Candidate genes in alcoholism. Clin Neurosci 3:174-181.
31. Goodwin GM. 1989. The effects of antidepressant treatments and lithium upon 5-HT1A receptor function. Prog Neuropsychopharmacol Biol Psychiatry 13:445-451.
32. Gutierrez B, Fananas L, Arranz MJ, Valles V, Guillamat R, van Os J, Collier D. 1996. Allelic association analysis of the 5-HT2C receptor gene in bipolar affective disorder. Neurosci Lett 212:65-67.
33. Heath MJ, Hen R. 1995. Serotonin receptors. Genetic insights into serotonin function. Current Biol 5:997-999.
34. Holmes C, Arranz MJ, Powell JF, Collier DA, Lovestone S. 1998. 5-HT2A and 5-HT2C receptor polymorphisms and psychopathology in late onset Alzheimer disease. Hum Mol Genet 7:1507-1509.
35. Inayama Y, Yoneda H, Sakai T, Ishida T, Nonomura Y, Kono Y, Takahata R, Koh J, Sakai J, Takai A, et al. 1996. Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia. Am J Med Gen 67:103-105.
36. Jacobs BL, Fornal CA. 1995. Serotonin and behavior. A general hypothesis. In: Bloom FE, Kupfer DJ, editors. Psychopharmacology: the fourth generation of progress. New York: Raven Press, p 461-469.
37. Kawanishi C, Hanihara T, Shimoda Y, Suzuki K, Sugiyama N, Onishi H, Miyakawa T, Yamada Y, Kosaka K. 1998a. Lack of association between neuroleptic malignant syndrome and polymorphisms in the 5-Ht1a and 5-Ht2a receptor genes. Am J Psychiatry 155:1275-1277.
38. Kawanishi Y, Harada S, Tachikawa H, Okubo T, Shiraishi H. 1998b. Novel mutations in the promoter and coding region of the human 5-Ht1a receptor gene and association analysis in schizophrenia. Am J Med Gen 81:434-439.
39. Kendler KS, Karkowski-Shuman L, FA ON, Straub RE, MacLean CJ, Walsh D. 1997. Resemblance of psychotic symptoms and syndromes in affected sibling pairs from the Irish Study of High-Density Schizophrenia Families: evidence for possible etiologic heterogeneity. Am J Psychiatry 154:191-198.
40. Kobilka BK, Frielle T, Collins S, Yang-Feng T, Kobilka TS, Francke U, Lefkowitz RJ, Caron MG. 1987. An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature 329:75-79.
41. Lahiri DK, Nurnberger JIJ. 1991. A rapid non-enzimatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acid Res 19:5444.
42. Lam S, Shen Y, Nguyen T, Messier TL, Brann M, Comings D, George SR, Dowd BF. 1996. A serotonin receptor gene (5HT1A) variant found in a Tourette's syndrome patient. Biochem Biophys Res Commun 219:853-858.
43. Lappalainen J, Zhang L, Dean M, Oz M, Ozaki N, Yu DH, Virkkunen M, Weight F, Linnoila M, Goldman D. 1995. Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C). Genomics 27:274-279.
44. Leckman JF, Sholomskas D, Thompson WD, Belanger A, Weissman MM. 1982. Best estimate of lifetime psychiatric diagnosis: a methodological study. Arch Gen Psychiatry 39:879-883.
45. Lentes KU, Hinney A, Ziegler A, Rosenkranz K, Wurmser H, Barth N, Jacob K, Coners H, Mayer H, Grzeschik KH, et al. 1997. Evaluation of a Cys23Ser mutation within the human 5-HT2C receptor gene: no evidence for an association of the mutant allele with obesity or underweight in children, adolescents and young adults. Life Sci 61:PL9-PL16.
46. Liddle PF. 1987. The symptoms of chronic schizophrenia. A re-examination of the positive-negative dichotomy. Br J Psychiatry 151:145-151.
47. Liddle PF, Barnes TRE. 1990. Syndromes of chronic schizophrenia. Br J Psychiatry 157:558-561.
48. Loftus J, DeLisi LE, Crow TJ. 1998. Familial associations of subsyndromes of psychosis in affected sibling pairs with schizophrenia and schizoaffective disorder. Psychiatry Res 80:101-111.
49. Martin JR, Bos M, Jenck F, Moreau J, Mutel V, Sleight AJ, Wichmann J, Andrews JS, Berendsen HH, Broekkamp CL, et al. 1998. 5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential. J Pharmacol Exp Ther 286:913-924.
50. Maziade M, Roy MA, Martinez M, Cliche D, Fournier JP, Garneau Y, Nicole L, Montgrain N, Dion C, Ponton AM. 1995. Negative, psychoticism, and disorganized dimensions in patients with familial schizophrenia or bipolar disorder: continuity and discontinuity between the major psychoses. Am J Psychiatry 152:1458-1463.
51. Maziade M, Bouchard S, Gingras N, Charron L, Cardinal A, Roy MA, Gauthier B, Tremblay G, Cote S, Fournier C, et al. 1996. Long-term stability of diagnosis and symptom dimensions in a systematic sample of patients with onset of schizophrenia in childhood and early adolescence. II: Postnegative distinction and childhood predictors of adult outcome. Br J Psychiatry 169:371-378.
52. McGuffin P, Farmer A, Harvey I. 1991. A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Arch Gen Psychiatry 48:764-770.
53. Moreau JL, Bos M, Jenck F, Martin JR, Mortas P, Wichmann J. 1996. 5HT2C receptor agonists exhibit antidepressant-like properties in the anhedonia model of depression in rats. Eur Neuropsychopharmacol 6:169-175.
54. Nakhai B, Nielsen DA, Linnoila M, Goldman D. 1995. Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28. Biochem Biophys Res Commun 210:530-536.
55. Oruc L, Verheyen GR, Furac I, Jakovljevic M, Ivezic S, Raeymaekers P, Van Broeckhoven C. 1997. Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder. Am J Med Gen 74: 504-506.
56. Ozaki N. 1996. [Molecular genetic approach to schizophrenia: direct analysis of 5-HT receptor genes]. Nihon Shinkei Seishin Yakurigaku Zasshi 16:175-180.
57. Pandey SC, Lumeng L, Li TK. 1996. Serotonin2C receptors and serotonin2C receptor-mediated phosphoinositide hydrolysis in the brain of alcohol-preferring and alcohol-nonpreferring rats. Alcohol Clin Exp Res 20:1038-1042.
58. Peralta V, Cuesta M, De Leon J. 1994. An empirical analysis of latent structures underlying schizophrenic symptoms: a four-syndrome model. Biol Psychiatry 36:726-736.
59. Peralta V, de Leon J, Cuesta MJ. 1992. Are there more than two syndromes in schizophrenia? A critique of the positive-negative dichotomy. Br J Psychiatry 161:335-343.
60. Risch N. 1990. Linkage strategies for genetically complex traits: I. Multilocus models. Am J Med Gen 46:222-228.
61. Segman RH, Ebstein RP, Heresco-Levy U, Gorfine M, Avnon M, Gur E, Nemanov L, Lerer B. 1997. Schizophrenia, chronic hospitalization and the 5-HT2C receptor gene. Psychiatr Genet 7:75-78.
62. Serretti A, Macciardi F, Smeraldi E. 1996. Identification of symptomatologic patterns common to major psychoses: proposal for a phenotype definition. Am J Med Gen 67:393-400.
63. Serretti A, Macciardi F, Cusin C, Lattuada E, Lilli R, Di Bella D, Catalano M, Smeraldi E. 1998a. GABAA Alpha-1 subunit gene not associated with depressive symptomatology in mood disorders. Psychiatr Genet 8:251-254.
64. Serretti A, Macciardi F, Cusin C, Lattuada E, Lilli R, Smeraldi E. 1998b. Dopamine receptor D-4 gene is associated with delusional symptomatology in mood disorders. Psychiatry Res 80:129-136.
65. Serretti A, Macciardi F, Smeraldi E. 1998c. Dopamine receptor D2 ser cys311 variant associated with disorganized symptomatology of schizophrenia. Schizophr Res 34:207-210.
66. Serretti A, Macciardi F, Verga M, Cusin C, Pedrini S, Smeraldi E. 1998d. Tyrosine hydroxylase gene associated with depressive symptomatology in mood disorder. Am J Med Gen 81:127-130.
67. Serretti A, Catalano M, Smeraldi E. 1999a. Serotonin transporter gene is not associated with symptomatology of schizophrenia. Schizophr Res 35:33-39.
68. Serretti A, Macciardi F, Cusin C, Lattuada E, Lilli R, Bella DD, Catalano M, Smeraldi E. 1999b. No interaction of GABA(A) alpha-1 subunit and dopamine receptor D4 exon 3 genes in symptomatology of major psychoses. Am J Med Gen 88:44-49.
69. Souery D, Lipp O, Serretti A, Mahieu B, Rivelli SK, Cavallini C, Ackenheil M, Adolfsson R, Aschauer H, Blackwood D, et al. 1998. European Collaborative Project on Affective Disorders: interactions between genetic and psychosocial vulnerability factors. Psychiatr Genet 8:197-205.
70. Toth M. 1996. Transcriptional regulation of the 5-HT2A receptor. Behav Brain Res 73:183-186.
71. Tsuang M, Faraone S. 1990. The genetics of mood disorders. Baltimore: Johns Hopkins University Press.
72. Van Os J, Fahy TA, Jones P, Harvey I, Sham P, Lewis S, Bebbington P, Toone B, Williams M, Murray R. 1996. Psychopathological syndromes in the functional psychoses: associations with course and outcome. Psychol Med 26:161-176.
73. Van Os J, Marcelis M, Sham P, Jones P, Gilvarry K, Murray R. 1997. Psychopathological syndromes and familial morbid risk of psychosis. Br J Psychiatry 170:241-246.
74. Winokur G, Coryell W, Endicott J, Akiskal H. 1993. Further distinctions between manic-depressive illness (bipolar disorder) and primary depressive disorder (unipolar depression). Am J Psychiatry 150:1176-1181.
75. Xie DW, Deng ZL, Ishigaki T, Nakamura Y, Suzuki Y, Miyasato K, Ohara K, Ohara K. 1995. The gene encoding the 5-HT1A receptor is intact in mood disorders. Neuropsychopharmacology 12:263-268.
76. Xie E, Zhu L, Zhao L, Chang LS. 1996. The human serotonin 5-HT2C receptor: complete cDNA, genomic structure, and alternatively spliced variant. Genomics 35:551-561.
77. Zanardi R, Artigas F, Franchini L, Sforzini L, Gasperini M, Smeraldi E, Perez J. 1997. How long should Pindolol be associated with Paroxetine to improve the antidepressant response? J Clin Psychopharmacol 17: 446-450.
78. Zhang HY, Ishigaki T, Tani K, Chen K, Shin JC, Miyasato K, Ohara K, Ohara K. 1997. Serotonin 2A receptor gene polymorphism in mood disorders. Biol Psychiatry 41:768-773.