Relationship of psychopathology to the human serotonin(1B) genotype and receptor binding kinetics in postmortem brain tissue

Neuropsychopharmacology

Volumn 21, Issue 2, 1999, Pages 238-246

  Huang, Yung Yu ^a,b   Grailhe, Régis ^b   Arango, Victoria ^a,b   Hen, René ^b   Mann, J John ^a  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Human 5 HT(1B) gene; Polymorphisms; Serotonin; Suicide

Indexed keywords

SEROTONIN 1B RECEPTOR;

AGGRESSION; ALCOHOLISM; ARTICLE; AUTOPSY; BRAIN TISSUE; CONTROLLED STUDY; DEPRESSION; DNA POLYMORPHISM; FEMALE; GENOTYPE; HUMAN; HUMAN TISSUE; KINETICS; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; POLYMERASE CHAIN REACTION; PREFRONTAL CORTEX; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR GENE; SINGLE STRAND CONFORMATION POLYMORPHISM; SUICIDE;

ACCIDENTS, TRAFFIC; ADULT; AGGRESSION; ALCOHOLISM; ANIMALS; AUTOPSY; BRAIN; DEPRESSIVE DISORDER; FEMALE; GENOTYPE; HOMICIDE; HUMANS; MALE; MENTAL DISORDERS; MICE; MICE, KNOCKOUT; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTORS, SEROTONIN; REFERENCE VALUES; SUBSTANCE-RELATED DISORDERS; SUICIDE;

EID: 0032973456     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(99)00030-5     Document Type: Article

References (43)

1. 2 and β-adrenergic receptor binding sites in the brain of suicide victims. Arch Gen Psychiatry. 47:1990;1038-1047.
2. 2 receptors in suicide victims. Biol Psych. 35:1994;457-461.
3. Ballenger J.C., Goodwin F.K., Major L.F., Brown G.L. Alcohol and central serotonin metabolism in man. Arch Gen Psychiatry. 36:1979;224-227.
4. 1B receptor is localized predominantly on axon terminals. Neuroscience. 58(1):1994;167-182.
5. Brent D.A., Bridge J., Johnson B.A., Connolly J. Suicidal behavior runs in families. Arch Gen Psychiatry. 53:1996;1145-1152.
6. Crabbe J., Philip T., Feller D., Hen R., Wenger C., Lessov C., Schafer G. Elevate alcohol consumption in null mutant mice lacking 5-HT1B receptors. Nature Genet. 13:1996;98-101.
7. Coppen A. Indoleamines and affective disorders. J Psychiat Res. 9:1972;163-171.
8. Demchyshyn L., Sunahara R.K., Miller K., Teitler M., Hoffman B.J., Kennedy J.L., Seeman P., Van Tol H.H.M., Niznik H.B. A human serotonin 1D receptor variant (5HT1Dβ) encoded by an intronless gene on chromosome 6. Proc Natl Acad Sci USA. 89:1992;5522-5526.
9. Gershon E.S., Berrettini W.H., Numberger J.I. Jr., Goldin L.R. Genetic studies of affective illness. Mann J.J. Models of Depressive Disorder. 1989;109-142 Plenum, New York, NY.
10. Goodwin F.K., Post R.M. 5-hydroxytryptamine and depression. A model for the interaction of normal variance with pathology Br J Clin Pharmac. 15(suppl):1983;393S-405S.
11. Hamblin M.W., Metcalf M.A. Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. Mol Pharmacol. 40:1991;143-148.
12. 1D receptor subtypes. [Review] Trends Pharmacol Sci. 17(3):1996;103-105.
13. Higley J.D., Mehlman P.T., Taub D.M., Higley S.B., Suomi S.J., Vickers J.H., Linnoila M. Cerebrospinal fluid monoamine and adrenal correlates of aggression in free-ranging rhesus monkeys. Arch Gen Psychiatry. 49:1992;436-441.
14. Hoyer D., Middlemiss D.N. Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain. Trends Pharmacol Sci. 10:1989;130-132.
15. Ishikawa K., Shibanoki S., Kubo T., Kogure M., Imamura Y., Osawa N., Ohmura M., Mikoshiba K. Functional difference in monoamine transmitters in the bahaviorally abnormal mouse mutant (wriggle mouse sagami). Neurosci Lett. 103(3):1989;343-348.
16. Kelly T.M., Mann J.J. Validity of DSM-III-R diagnosis by psychological autopsy. A comparison with antemortem diagnosis Acta Psychiatric Scand. 94:1996;124-130.
17. 1Dβ autoreceptor gene on chromosome 6 and direct analysis for sequence variants. Am J Med Genet [Neuropsychiatric Genetics]. 60:1995;157-161.
18. Lappalainen J., Long J.C., Eggert M., Ozaki N., Robin R.W., Brown G.L., Naukkarinen H., Virkkunen M., Linnoila M., Goldman D. Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations. Arch Gen Psychiatry. 55:1998;989-994.
19. Levy F.O., Guderman T., Reyes-Perez E., Birnbaumer M., Kauman A.J., Birnbaumer L. Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype. J Biol Chem. 267:1992;7553-7562.
20. Lowry O.H., Rosebrough M.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J Biol Chem. 193:1951;265-275.
21. 1D binding in globus pallidus but not cortex Mol Psychiatry. 2:1997;314-321.
22. Mann J.J. The Neurobiology of suicide. [Review]. Nature Med. 4:1998;25-30.
23. Mann J.J., Arango V. Neurobiology of suicidal behavior. Jacobs D.G. Harvard Medical School Guide to Suicide Assessment and Intervention. 1998;98-114 Jossey-Bass Publishers, San Francisco, CA.
24. Martin G.R., Humphrey P.P.A. Receptors for 5-hydroxytryptamine. Current perspectives on classification and nomenclature Neuropharmacology. 33:1994;261-273.
25. Molina V., Ciesielski L., Gobaille S., Isel F., Mandel P. Inhibition of mouse killing behavior by serotonin mimetic drugs effects of partial alterations of serotonin neurotransmission. Pharmacol Biochem Behav. 27(1):1987;123-131.
26. Nöthen M.M., Erdman J., Shimron-Abarbanell D., Propping P. Identification of genetic variation in the human serotonin 5-HT1Dβ receptor gene. Biochem Biophysic Res Comm. 205:1994;1194-1200.
27. Olivier B., Most J. Serenics, serotonin and aggression. [Review]. Progr Clin Biol Res. 361:1990;203-230.
28. Orita M., Iwahana H., Kanazawa H., Hayashi K., Sekiya T. Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc Natl Acad Sci USA. 86:1989;2766-2770.
29. 1D binding sites. Eur J Pharmacol. 163:1989;133-136.
30. Ramboz S., Saudou F., Amara D.A., Belzung C., Segu L., Misslin R., Buhot M.C., Hen R. 5-HT1B receptor knock out - behavioral consequences. Behav Brain Res. 73:1996;305-312.
31. Rocha B.A., Scearce-Levie K., Lucas J.J., Hiroi N., Castanon N., Crabbe J.C., Nestler E.J., Hen R. Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. Nature. 393:1998;175-178.
32. Roy A. Genetics of suicide. Ann NY Acad Sci. 487:1986;97-105.
33. Roy A., Segal N.L., Centerwall B.S., Robinette C.D. Suicide in twins. Arch Gen Psychiatry. 48:1991;29-32.
34. 1B receptor. Science. 265:1994;1875-1878.
35. Schuckit M.A., Li A.T.K., Cloninger C.R., Deitrich R.A. Genetics of alcoholism. [clinical conference]. Alcohol Clin Exp Res. 9:1985;475-492.
36. Schulsinger F., Kety S.S., Rosenthal D., Wender P.H. A family study of suicide. Schou M., Stromgren E. Origin, Prevention and Treatment of Affective Disorders. 1979;277-287 Academic Press, New York, NY.
37. 1Dβ) not linked to schizophrenia in five Canadian pedigrees. Human Hered. 43:1993;15-318.
38. Stanley M., Mann J.J. Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet. i:1983;214-216.
39. Stanley M., Virgilio J., Gershon S. Tritiated imipramine binding sites are decreased in the frontal cortex of suicides. Science. 216:1982;1337-1339.
40. van Harten J. Clinical pharmacokinetics of selective serotonin reuptake inhibitors [Review]. Clinical Pharmacokinetics. 24(3):1993;203-220.
41. Vergnes M., Depaulis A., Boehrer A. Parachlorophenylalanine-induced serotonin depletion increases offensive but not defensive aggression in male rats. Physiol & Behav. 36:1986;653-658.
42. Virkkunen M., Rawlings R., Tokola R., Kallio E., Poland R.E., Guidotti A., Nemeroff C., Bissette G., Kalogeras K., Karonen S.-L., Linnoila M. CSF biochemistries, glucose metabolism, diurnal rhythms, personality profiles and state aggressiveness in Finnish violent offenders, impulsive fire setters and healthy volunteers. Arch Gen Psychiatry. 51:1994;20-27.
43. 1Dβ Proc Natl Acad Sci USA. 89:1992;3630-3634.