Genetic associations with clinical characteristics in bipolar affective disorder and recurrent unipolar depressive disorder

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 96, Issue 1, 2000, Pages 36-42

  Ho, Luk W ^a   Furlong, Robert A ^b   Rubinsztein, Judy S ^a   Walsh, Cathy ^a   Paykel, Eugene S ^a   Rubinsztein, David C ^b,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Bipolar affective disorder; Depression; Dopamine; Monoamine oxidase; Serotonin transporter

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; DOPAMINE RECEPTOR; SEROTONIN TRANSPORTER; TRYPTOPHAN HYDROXYLASE; TYROSINE 3 MONOOXYGENASE;

ADULT; ARTICLE; DEPRESSION; FEMALE; GENDER; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MANIA; MANIC DEPRESSIVE PSYCHOSIS; PRIORITY JOURNAL; PSYCHOSIS; SUICIDE; VARIABLE NUMBER OF TANDEM REPEAT;

BASE SEQUENCE; BIPOLAR DISORDER; CARRIER PROTEINS; DEPRESSIVE DISORDER; DNA PRIMERS; FEMALE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MONOAMINE OXIDASE; NERVE TISSUE PROTEINS; RECEPTORS, DOPAMINE D2; RECURRENCE; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TRYPTOPHAN HYDROXYLASE; TYROSINE 3-MONOOXYGENASE;

EID: 0034615045     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(20000207)96:1<36::AID-AJMG8>3.0.CO;2-6     Document Type: Article

References (56)

1. Arinami T, Gao M, Hamaguchi H, Toru M. 1997. A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Hum Mol Genet 6:577-582.
2. Arinami T, Itokawa M, Aoki J, Shibuya H, Ookubo Y, Iwawaki A, Ota K, Shimizu H, Hamaguchi H, Toru M. 1996. Further association study on dopamine D2 receptor variant S311C in schizophrenia and affective disorders. Am J Med Genet 67:133-138.
3. Bellivier F, Leboyer M, Courtet P, Buresi C, Beaufils B, Samolyk D, Allilaire JF, Feingold J, Mallet J, Malafosse A. 1998. Association between the tryptophan hydroxylase gene and manic-depressive illness. Arch Gen Psychiatry 55-33-37.
4. Boyer WF, Feighner JP. 1991. The serotonin hypothesis: necessary but not sufficient. In Feighner JP, Boyer WF, editors. Selective Serotonin Reuptake Inhibitors. Chichester: Wiley. p 71-80.
5. Brunner HG, Nelen MR, Breakefield XO, Ropers HH, van Oost BA. 1993a. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 262:578-580.
6. Brunner HG, Nelen MR, van Zandvoort P, Abeling NG, van Gennip AH, Wolters EC, Kuiper MA, Ropers HH, van Oost BA. 1993b. X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism. Am J Hum Genet 52:1032-1039.
7. Collier DA, Arranz MJ, Sham P, Battersby S, Vallada HP, Gill P, Aitchison KJ, Sodhi M, Li T, Roberts GW, Smith B, Morton J, Murray RM, Smith D, Kirov G. 1996a. The serotonin transporter is a potential susceptibility factor for bipolar affective disorder. Neuroreport 7:1675-1679.
8. Collier DA, Stober G, Li T, Heils A, Catalano M, Di Bella D, Arranz MJ, Murray RM, Vallada HP, Bengel D, Muller CR, Roberts GW, Smeraldi E, Kirov G, Sham P, Lesch KP. 1996b. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1:453-460.
9. Craddock N, Daniels J, Roberts E, Rees M, McGuffin P, Owen MJ. 1995a. No evidence for allelic association between bipolar affective disorder and monoamine oxidase A gene polymorphisms. Am J Med Genet 60: 322-324.
10. Craddock N, Rees M, Norton N, Feldman E, McGuffin P, Owen MJ. 1996. Association of bipolar disorder and the VNTR polymorphism in intron 2 of the human serotonin transporter (hSERT). Psychiatr Genet 6:147.
11. Craddock N, Roberts Q, Williams N, McGuffin P, Owens MJ. 1995b. Association study of bipolar disorder using a functional polymorphism (Ser311-Cys) in the dopamine D2 receptor gene. Psychiatr Genet 5:63-65.
12. Delgado PL, Price LH, Heninger GR, Charney DS. 1992. Neurochemistry. In Paykel ES (ed): Handbook of Affective Disorders. Edinburgh: Churchill Livingstone. p 219-253.
13. Furlong RA, Coleman TA, Ho LW, Rubinsztein JS, Walsh C, Paykel ES, Rubinsztein DC. 1998c. No association of a functional polymorphism in the dopamine D2 receptor promoter region with bipolar affective disorder or unipolar affective disorder. Am J Med Genet 81:385-387.
14. Furlong RA, Ho LW, Rubinsztein JS, Walsh C, Paykel ES, Rubinsztein DC. 1998b. No association of the tryptophan hydroxylase gene with bipolar affective disorder, unipolar affective disorder, or suicidal behavior in major affective disorder. Am J Med Genet 81:245-247.
15. Furlong RA, Ho LW, Rubinsztein JS, Walsh C, Paykel ES, Rubinsztein DC. 1999a. Analysis of the monoamine oxidase A (MAOA) gene in bipolar affective disorder by association studies, meta-analyses, and sequencing of the promoter. Am J Med Genet 88:398-406.
16. Furlong RA, Ho LW, Walsh C, Rubinsztein JS, Jain S, Paykel ES, Easton DF, Rubinsztein DC. 1998a. Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. Am J Med Genet 81:58-63.
17. Furlong RA, Rubinsztein JS, Ho LW, Walsh C, Coleman TA, Paykel ES, Blackwood DHR, Rubinsztein DC. 1999b. Analysis and meta-analysis of two polymorphisms within the tyrosine hydroxylase gene in bipolar and unipolar affective disorders. Am J Med Genet 88:88-94.
18. Goodman SN. 1998. Multiple comparisons, explained. Am J Epidemiol 147: 807-813.
19. Gutierrez B, Arranz MJ, Collier DA, Valles V, Guillamat R, Bertranpetit J, Murray RM, Fanas L. 1998. Serotonin transporter gene and risk for bipolar affective disorder: an association study in Spanish population. Biol Psychiatry 43:843-847.
20. Heninger GR, Delgado PL, Charney DS. 1996. The revised monoamine theory of depression: a modulatory role for monoamines, based on new findings from monoamine depletion experiments in humans. Pharmacopsychiatry 29:2-11.
21. Horton RW. 1992. The neurochemistry of depression: evidence derived from studies of post-mortem brain tissue. Mol Aspects Med 13:191-203.
22. Hotamisligil GS, Breakefield XO. 1991. Human monoamine oxidase A gene determines levels of enzyme activity. Am J Hum Genet 49:383-392.
23. Hsu Y-PP, Loh EW, Chen WJ, Chen CC, Yu J-M, Cheng ATA. 1996. Association of monoamine oxidase A alleles with alcoholism among male Chinese in Taiwan. Am J Psychiatry 153:1209-1211.
24. Kawada Y, Hattori M, Fukuda R, Arai H, Inoue R, Nanko S. 1995. No evidence of linkage or association between tyrosine hydroxylase gene and affective disorder. J Affect Disord 34:89-94.
25. Kunugi H, Tatsumi M, Sakai T, Hattori M, Nanko S. 1996. Serotonin transporter gene polymorphism and affective disorder. Lancet 347: 1340.
26. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
27. Lim LCC, Powell J, Sham P, Castle D, Hunt N, Murray R, Gill M. 1995. Evidence for a genetic association between alleles of monoamine oxidase A gene and bipolar affective disorder. Am J Med Genet 60:578-580.
28. MacKinnon DF, Jamison KR, DePaulo JR. 1997. Genetics of manic depressive illness. Ann Rev Neurosci 20:355-373.
29. Malafosse A, Leboyer M, d'Amato T, Amadeo S, Abbar M, Campion D, Canseil O, Castelnau D, Gheysen F, Granger B, Henrikson B, Poirier M-F, Sabate O, Samolyk D, Feingold J, Mallet J. 1997. Manic-depressive illness and tyrosine hydroxylase gene: linkage heterogeneity and association. Neurobiol Disease 4:337-349.
30. Manki H, Kanba S, Muramatsu T, Higuchi S, Suzuki E, Matsushita S, Ono Y, Chiba H, Shintani F, Nakamura M, Yagi G, Asai M. 1996. Dopamine D2, D3, and D4 receptor and transporter gene polymorphisms and mood disorders. J Affect Disord 40:7-13.
31. Mann JJ, Malone KM, Nielsen DA, Goldman D, Erdos J, Gelernter J. 1997. Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients. Am J Psychiatry 154:1451-1453.
32. Meloni R, Leboyer M, Bellivier F, Barbe B, Samolyk D, Allilaire JF, Mallet J. 1995. Association of manic-depressive illness with tyrosine hydroxylase microsatellite marker. Lancet 345:932.
33. Muramatsu T, Matsushita S, Kanba S, Higuchi S, Manki H, Suzuki E, Asai M. 1997. Monoamine oxidase genes polymorphisms and mood disorder. Am J Med Genet 74:494-496.
34. Nielsen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M. 1994. Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Arch Gen Psychiatry 51:34-38.
35. Nielsen DA, Virkkunen M, Lappalainen J, Eggert M, Brown GL, Long JC, Goldman D, Linnoila M. 1998. A tryptophan hydroxylase gene marker for suicidality and alcoholism. Arch Gen Psychiatry 55:593-602.
36. Nothen MM, Eggermann K, Albus M, Borrmann M, Rietschel M, Korner J, Maier W, Minges J, Lichtermann D, Franzek E, Weigelt B, Knapp M, Propping P. 1995. Association analysis of the monoamine oxidase A gene in bipolar affective disorder by using family-based controls. Am J Hum Genet 57:975-977.
37. Nothen MM, Erdmann J, Korner J. 1992. Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder. Am J Psychiatry 149:199-201.
38. Ogilvie AD, Battersby S, Bubb VJ, Fink G, Harmar AJ, Goodwin GM, Smith CAD. 1995. Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 347:731-733.
39. Ohara K, Nagai M, Tsukamoto T, Tani K, Suzuki Y, Ohara K. 1998. Functional polymorphism in the serotonin transporter promoter at the SLC6A4 locus and mood disorders. Biol Psychiatry 44:550-554.
40. Oruc L, Verheyen GR, Furac I, Jakovljevic M, Ivezic S, Raeymaekers P. Van Broeckhoven C. 1997. Analysis of the tyrosine hydroxylase and dopamine D4 receptor genes in a Croatian sample of bipolar I and unipolar patients. Am J Med Genet 74:176-178.
41. Owens MJ, Nemeroff CB. 1994. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem 40:288-295.
42. Parsian A, Suarez BK, Tabakoff B, Hoffman P, Ovchinnikova L, Fisher L, Cloninger CR. 1995. Monoamine oxidase and alcoholism. I: Studies in unrelated alcoholics and normal controls. Am J Med Genet (Neuropsychiatr Genet) 60:409-416.
43. Parsian A, Todd RD. 1997. Genetic association between monoamine oxidase and manic-depressive illness: comparison of relative risk and haplotype relative risk data. Am J Med Genet 74:475-479.
44. Perez de Castro I, Santos J, Torres P, Visedo G, Saiz-Ruiz J, Llinares C, Fernandez-Piqueras J. 1995. A weak association between TH and DRD2 genes and bipolar affective disorder in a Spanish sample. J Med Genet 32:131-134.
45. Perneger TV. 1998. What's wrong with Bonferroni adjustments? BMJ 316: 1236-1238.
46. Rosner B. 1990. Fundamentals of Biostatistics. Boston: Thomson Information Publishing Group, p 358-360.
47. Rubinsztein DC, Leggo J, Goodburn S, Walsh C, Jain S, Paykel ES. 1996. Genetic association between monoamine oxidase A microsatellite and RFLP alleles and bipolar affective disorder: analysis and metaanalysis. Hum Mol Genet 5:779-782.
48. Savitz DA, Olshan AF. 1998. Describing data requires no adjustment for multiple comparisons: a reply from Savitz and Olshan. Am J Epidemiol 147:813-815.
49. Seeman P. 1992. Dopamine receptor sequences: therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4. Neuropsychopharmacology 7:261-284.
50. Seeman P, Lee T, Chau-Wong M, Wong K. 1976. Antipsychotic drug doses and neuroleptic/dopamine receptors. Nature 261:717-719.
51. Souery D, Lipp O, Mahieu B, Mendelbaum K, De Martelaer V, Van Broeckhoven C, Mendlewicz J. 1996. Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1 and TH genes. Am J Med Genet 67:551-555.
52. Spitzer RL, Endicott J. 1978. A diagnostic interview - the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 35:837-844.
53. Stober G, Heils A, Lesch KP. 1996. Serotonin transporter gene polymorphism and affective disorder. Lancet 347:1340-1341.
54. Thompson JR. 1998a. Invited commentary: Re: Multiple comparisons and related issues in the interpretation of epidemiological data. Am J Epidemiol 147:801-807.
55. Thompson JR. 1998b. A response to Describing data requires no adjustment for multiple comparisons. Am J Epidemiol 147:815.
56. Turecki G, Rouleau GA, Mari J, Joober R, Morgan K. 1997. Lack of association between bipolar disorder and tyrosine hydoxylase: a metaanalysis. Am J Med Genet 74:348-352.