Chapter 12 Molecular physiology of mammalian epithelial Na+/H+ exchangers NHE2 and NHE3

Current Topics in Membranes

Volumn 50, Issue , 2000, Pages

  Donowitz, Mark ^a   Tse, Ming ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0038824301     PISSN: 10635823     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s1063-5823(00)50014-3     Document Type: Review

References (242)

1. O. Aharonovitz N. Demaurex M. Woodside S. Grinstein ATP dependence is not an intrinsic property of Na+/H+ exchanger: NHE1: Requirement for an ancillary factor Am. J. Physiol. 276 1999 C1303 1311
2. S. Akhter M. Cavet C.M. Tse M. Donowitz C-terminal domains of Na'/H+ exchanger isoform 3 are involved in the basal and serum-stimulated membrane trafficking of the exchanger Biochemistry 39 2000 1990 2000 2000
3. + exchanger isofrom NHE3 Am. J. Physiol. 276 1999 C136 C144
4. R.J. Alpern Y. Yamaji A. Cano S. Horie R.T. Miller O.W. Moe P.A. Preisig Chronic regulation of the Na/H antiporter J. Lab. Clin. Med. 122 1993 137 140
5. R.J. Alpern Cell mechanisms of proximal tubule acidification Physiol. Rev. 70 1990 79 114
6. 3 to Src Kidney Int. 48 1995 1386 1396
7. M. Amemiya J. Loffing M. Lotscher B. Kaissling R.J. Alpern O.W. Moe Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb Kidney Int. 48 1995 1206 1215
8. + media increases NHE3 activity after early decrease in intracellular pH Am. J. Physiol. 276 1999 C711 0716
9. M. Amemiya Y. Yamaji A. Cano O.W. Moe R.J. Alpem Acid incubation increases NHE3 mRNA abundance in OKP cells Am. J. Physiol. 269 1995 C126 0133
10. P.M. Ambuhl M. Amemiya M. Danczkay M. Lotscher B. Kaissling O.W. Moe P.A. Preisig R.J. Alpem Chronic metabolic acidosis increases NHE3 protein abundance in rat kidney Am. J. Physiol. 271 1996 F917 F925
11. + exchanger 3 (NHE3) J. Clin. Invest. 103 1999 429 435
12. I. Anderie R. Blum W. Haase S. Grinstein F. Thevenod Expression of NHEI in rat pancreatic zymogen granule membranes Biochem. Biophys. Res. Commun. 246 1998 330 336
13. + antiport in Arabidopsis Science 285 1999 1256 1258
14. + exchanger (NHE5) highly expressed in brain J. Biol. Chem. 274 1999 4383 4388
15. + exchanger isoforms and their regulation by thyroid hormone Am. J. Physiol. 270 1996 C585 0592
16. + exchanger isoforms in rabbit parietal cells Am. J. Physiol. 275 1998 G1085 G1093
17. + exchanger isoform 5 (NHE5) from human brain J. Biol. Chem. 274 1999 4377 4382
18. D.L. Barber M.B. Ganz Guanine nucleotides regulate beta-adrenergic activation of Na/H exchange independently of receptor coupling to Gs J. Biol. Chem. 267 1992 20607 20612
19. M. Baum M. Amemiya V. Dwarakanath R.J. Alpern O.W. Moe Glucocorticoids regulate NHE3 transcription in OKP cells Am. J. Physiol. 270 1996 F164 F169
20. + antiporter in OKP cells Am. J. Physiol. 264 1993 F1027 F1031
21. M. Baum O.W. Moe D.L. Gentry R.J. Alpem Effect of glucocorticoids on renal cortical NHE3 and NHE1 mRNA Am. J. Physiol. 267 1994 F437 F442
22. H.M. Berschneider M.R. Knowles R.G. Azizkhan R.C. Boucher N.A. Tobey R.C. Orlando D.W. Powell Altered intestinal chloride transport in cystic fibrosis FASEB J. 2 1988 2625 2629
23. + exchanger isoform 1 (NHEI) is a novel member of the calmodulin-binding proteins. Identification and characterization of calmodulin-binding sites J. Biol. Chem. 269 1994 13703 13709
24. + antiport to osmotic stress Am. J. Physiol. 269 1995 C998 C1007
25. + exchanger isoform NHEl: Role of phosphorylation Kidney Int. 49 1996 1038 1044
26. D. Biemesderfer B. DeGray P.S. Aronson Membrane topology of NHE3. Epitopes within the carboxyl-terminal hydrophilic domain are exoplasmic J. Biol. Chem. 273 1998 12391 12396
27. + exchanger isoform NHE3 in the proximal tubule J. Biol. Chem. 274 1999 17518 17524
28. + exchangerisoform of renal brush border Am. J. Physiol. 265 1993 F736 F742
29. D. Biemesderfer P.A. Rutherford T. Nagy J.H. Pizzonia A.K. Abu-Alfa P.S. Aronson Monoclonal antibodies for high-resolution localization of NHE3 in adult and neonatal rat kidney Am. J. Physiol. 273 1997 F289 F299
30. H.J. Binder S.K. Singh J.P. Geiber V.M. Rajendran Novel transport properties of colonic crypt cells: Fluid absorption and Cl-dependent NaH exchange Comp. Biochem. Physiol. A 118 1997 265 269
31. + exchanger isoform NHE-3 is species specific J. Lab. Clin. Med. 128 1996 304 312
32. + exchangers, NHE-1 and NHE-3, of rat intestine. Expression and localization J. Clin Invest 93 1994 106 113
33. + exchanger isoforms NHE2 and NHE4 in rat intestine and kidney Am. J. Physiol. 273 1997 C496 C505
34. + exchange: A cause of congenital secretory diarrhoea Lancet 8437 1985 1066 1069
35. + exchangers (NHEs) dictates the nature of the hormonal response: Behavior of a chimeric human NHE1/trout beta NHE antiporter Proc. Natl. Acad. Sci. USA 91 1994 5431 5435
36. + exchanger (NHE-3) isoform to chromosome 5p15.3 Genomics 15 1993 668 672
37. + exchanger isoform, NHE3 Am. J. Physiol. 26 1995 C198 C206
38. + exchanger NHE3 isoform J. Mot. Chem. 271 1996 3590 3599
39. M. Cabral J.H. Petosa M.J. Sutcliffe S. Raza O. Byron F. Poy S.M. Marfatia A.H. Chishti R.C. Liddington Crystal structure of a PDZ domain Nature 382 1996 649 652
40. A. Cano M. Baum O.W. Moe Thyroid hormone stimulates the renal Na/H exchanger NHE3 by transcriptional activation Am. J. Physiol. 276 1999 C102 C108
41. A. Cano P. Preisig R.J. Alpern Cyclic adenosine monophosphate acutely inhibits and chronically stimulates Na/H antiporter in OKP cells J. Clin. Invest. 92 1993 1632 1638
42. + exchangers (NHEl-3) have similar turnover numbers FASEB J. 13 1999 A400
43. B. Cha J. Nadarajah X.-T. Wang G. Lamprecht S.E. Guggino C. Yun Functional role of Na/H exchanger regulatory factor (NHERF) and localization in intestine and kidney Gastroenterology 116 1999 A3773
44. + exchanger isoform NHE2 in rat kidney Am. J. Physiol. 275 1998 F379 F386
45. J.H. Cho M.W. Musch C.M. Bookstein R.L. McSwine K. Rabenau E.B. Chang Aldosterone stimulates intestinal Na+ absorption in rats by increasing NHE3 expression of the proximal colon Am. J. Physiol. 274 1998 C586 0594
46. + exchange expression and activity in region-and tissue-specific manner Am. J. Physiol. 267 1994 C796 0803
47. + exchanger 2 isoform J. Biol. Chem. 274 1999 10481 10488
48. 2+/calmodulin-dependent protein kinase II, a brush border membrane protein Proc. Natl. Acad. Sci. USA 87 1990 8990 8994
49. + absorbing cells J. Clin. Invest. 88 1991 855 863
50. J.F. Collins P.R. Kiela H. Xu J. Zeng F.K. Ghishan Increased NHE2 expression in rat intestinal epithelium during ontogeny is transcriptionally regulated Am. J. Physiol. 275 1998 C1143 C1150
51. J.F. Collins H. Xu P.R. Kiela J. Zeng F.K. Ghishan Functional and molecular characterization of NHE3 expression during ontogeny in rat jejunal epithelium Am. J. Physiol. 273 1997 C1937 01946
52. + exchange gene (NHEI) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis Proc. Natl. Acad. Sci. USA 90 1993 4508 4512
53. + exchanger-1 J. Biol. Chem. 36 1997 2951 2959
54. + exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain Biochemistry 33 1994 10463 10469
55. + antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischentic properties Mol. Pharmacol. 44 1993 1041 1045
56. +-Cl-symport J. Membr. Biol. 129 1992 221 235
57. N. Demaurex W. Furuya S. D'Souza J.S. Bonifacino S. Grinstein Mechanism of acidification of the trans-Golgi network (TGN). In situ measurements of pH using retrieval of TGN38 and furin from the cell surface J. Biol. Chem. 273 1998 2044 2051
58. + exchange. Nucleotide specificity and assessment of the role of phospholipids J. Gen. Physiol. 109 1997 117 128
59. + conductance J. Gen. Physiol. 106 1995 85 111
60. +H+ exchanger NHE3 in Xenopus laevis renal epithelial cells (A6/C1) J. Physiol. 515 1999 829 842
61. M. Donowitz H.Y. Cheng G.W. Sharp Effects of phorbol esters on sodium and chloride transport in rat colon Am. J. Physiol. 251 1986 G509 G517
62. 2+/calmoduhn and protein kinase C J. Clin. Invest. 83 1989 1953 1962
63. + exchanger in colon and is increased by a low-NaCI diet Am. J. Physiol. 274 1998 R1659 R1669
64. M. Donowitz R. Kambadur M. Zizak S. Nath S. Akhter M. Tse NHE3 is a calmodulin binding protein: Calmoduhn inhibits NHE3 by binding to the C-terminal 76 amino acids of NHE3 Gastroenterology 112 1997 A360
65. M. Donowitz M.J. Welsh Regulation of mammalian small intestinal electrolyte secretion L.R. Johnson Physiology of the Gastrointestinal Tract 2nd Ed 1987 Raven Press New York
66. D.A. Doyle A. Lee J. Lewis E. Kim M. Sheng R. MacKinnon Crystal structures of a complexed and peptide-free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ Cell 85 1996 1067 1076
67. D.T. Drensfield A.J. Bradford J. Smith M. Martin C. Roy P.H. Mangeat J.R. Goldenring Ezrin is a cyclic AMP-dependent protein kinase anchoring protein EMBO J. 16 1997 35 43
68. + exchanger 3 accumulates and is functional in recycling endosomes J. Biol. Chem. 273 1998 2035 2043
69. + exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA Am. J. Physiol. 271 1996 G483 G493
70. + exchanger isoforms NHE-1 and NHE-3 exist as stable dimers with a high degree of specificity for homodimers J. Biol. Chem. 268 1994 2589 2596
71. L. Fan M.R. Wiederkehr R. Collazo H. Wang L.A. Crowder O.W. Moe Dual mechanisms of regulation of Na/H exchanger NHE-3 by parathyroid hormone in rat kidney J. Biol. Chem. 274 1999 11289 11295
72. J.M. Fell M.P. Miller Y. Finkel I.W. Booth Congenital sodium diarrhea with a partial defect in jejunal brush border membrane sodium transport, normal rectal transport, and resolving diarrhea J. Pediatr. Gastroenterol. Nutr. 15 1992 112 116
73. M. Field L.H. Graf Jr. W.J. Laird P.L. Smith Heat-stable enterotoxin of Escherichia coli : In vitro effects on guanylate cyclase activity, cyclic GNP concentration, and ion transport in small intestine Proc. Natl. Acad. Sci. USA 75 1978 2800 2804
74. + exchangers J. Pharmacol. Exp. Then 288 1999 620 626
75. + exchanger Biochem. Cell Biol. 76 1998 837 842
76. + antiiporter in Escherichia coli Proc. Natl. Acad. Sci. USA 90 1993 1212 1216
77. F.K. Ghishan S. Knobel J.A. Barnard M. Breyer Expression of a novel sodiumhydrogen exchanger in the gastrointestinal tract and kidney J. Membr. Biol. 144 1995 267 271
78. + exchanger (SLC9A2) Genomics 30 1995 25 30
79. T. Gonda D. Maouyo S.E. Rees M.H. Montrose Regulation of intracellular pH gradients by identified Na/H exchanger isoforms and a short-chain fatty acid Am. J. Physiol. 276 1999 G259 G270
80. D.W. Good Hyperosmolality inhibits bicarbonate absorption in rat medullary thick ascending limb via a protein-tyrosine kinase-dependent pathway J. Biol. Chem. 270 1995 9883 9889
81. + exchangers Proc. Natl. Acad. Sci. USA 92 1995 12525 12529
82. + exchanger Am. Physiol. Soc. 270 1996 C1493 C1502
83. + antiporter. Analysis of phosphorylation and subcellular localization J. Biol. Chem. 269 1994 8741 8748
84. + exchange in lymphocytes by phorbol esters. Change in the cytoplasmic pH-dependence of the antiport Proc. Natl. Acad. Sci. USA 82 1985 1429 1433
85. + antiport: Assessment of effects on intracellular pH EMBO J. 12 1993 5209 5218
86. + exchange and decreased sensitivity to amiloride Am. J. Physiol. 255 1988 C495 0501
87. + exchanger regulatory factor family of PDZ proteins Proc. Natl. Acad. Sci. USA 95 1998 8496 8501
88. + exhange Nature 392 1998 626 630
89. + exchanger (review) Int. J. Mol. Med. 3 1999 315 321
90. + exchanger Int. J. Mol. Med. 3 1999 315 321
91. + exchanger Biochem. J. 289 1993 637 640
92. X. He G.A.J. Kuijpers G. Goping J.A. Kulakusky C. Zheng C. Delporte C.M. Tse R.S. Redman M. Donowitz H.B. Pollard B.J. Baum A polarized salivary cell monolayer useful for studying transepithelial fluid movement in vitro Pflugers Arch. 435 1998 375 381
93. X. He C.M. Tse M. Donowitz S.L. Alper S.E. Gabriel B.J. Baum Polarized distribution of key membrane transport proteins in the rat submandibular gland Pflugers Arch. 433 1997 260 268
94. +-exchanger NHE3 in MDCK cells by vasotocin Pflugers Arch. 434 1997 123 131
95. C.B. Hensley M.E. Bradley A.K. Mircheff Parathyroid hormone-induced translocation of NaH antiporters in rat proximal tubules Am. J. Physiol. 257 1989 C637 C645
96. + diarrhea: A new type of secretory diarrhea J. Pediatr. 106 1985 56 61
97. W.A. Hoogerwerf S.C. Tsao O. Devuyst S.A. Levine C.H. Yun J.W. Yip M.E. Cohen P.D. Wilson A.J. Lazenby C.M. Tse M. Donowitz NHE2 and NHE3 are human and rabbit intestinal brush-border proteins Am. J. Physiol. 270 1996 G29 G41
98. + exchange through distinct Cdc42-dependent and RhoA-dependent pathways J. Biol. Chem. 271 1996 6152 6158
99. S. Horie O. Moe R.T. Miller R.J. Alpern Long-term activation of protein kinase C causes chronic Na/H antiporter stimulation in cultured proximal tubule cells J. Clin. Invest. 89 1992 365 372
100. + exchanger (NHEI): pH-maintenance, ATP-sensitive, and flexible loop domains J. Biochem. (Tokyo) 121 1997 295 303
101. M. Ikuma M. Kashgarian H.J. Binder V.M. Rajendran Differential regulation of NHE isoforms by sodium depletion in proximal and distal segments of rat colon Am. J. Physiol 276 1999 G539 G549
102. + exchanger (NHE3) in three clones of Caco-2 cells Am. J. Physiol. 277 1999 G292 G305
103. + exchanger isoform 3 in human colon adenocarcinoma cell line Caco-2. Protein kinase C-mediated inhibition of the exchanger J. Biol. Chem. 273 1998 8790 8798
104. A.J. Janecki M. Janecki S. Akhter M. Donowitz Basic fibroblast growth factor stimulates surface expression and activity of Na(+)/H(+) exchanger NHE3 via mechanism involving phosphatidylinositol 3-kinase J. Biol. Chem. 275 2000 8133 8142
105. +-antiport in restitution of isolated guinea pig gastric epithelium after superficial injury Dig. Dis. Sci. 41 1996 2187 2194
106. + exchanger NHE3 gene J. Biol. Chem. 271 1996 10551 10559
107. + exchanger regulates intracellular pH of rat gastric surface cells in vivo Pflugers Arch. 421 1992 322 328
108. + exchanger stably expressed in Chinese hamster ovary cells J. Biol. Chem. 269 1994 23544 23552
109. + exchangers J. Biol. Chem. 274 1999 8093 8102
110. K.M. Keller S. Wirth W. Baumann D. Sule I.W. Booth Defective jejunal brush border membrane sodium/proton exchange in association with lethal familial protracted diarrhoea Gut 31 1990 1156 1158
111. J.H. Kim L. Johannes B. Goud C. Antony C.A. Lingwood R. Daneman S. Grinstein Noninvasive measurement of the pH of the endoplasmic reticulum at rest and during calcium release Proc. Natl. Acad. Sci. USA 95 1998 2997 3002
112. + exchange activity in renal brush border membranes isolated from thyroid hormone-treated rats. J. Membr. Biol. 91, 183–191.
113. + exchanger (NHE5/ SLC9A5) to chromosome 16822.1 Genomics 25 1995 615 622
114. R.G. Knickelbein P.S. Aronson W. Atherton J.W. Dobbins Sodium and chloride transport across rabbit ileal brush border Am. J. Physiol. 245 1983 G504 G510
115. R.G. Knickelbein P.S. Aronson J.W. Dobbins Membrane distribution of sodium-hydrogen and chloride-bicarbonate exchangers in crypt and villus cell membranes from rabbit ileum J. Clin. Invest. 82 1988 2158 2163
116. + exchangers on villus cells in rabbit ileum Am. J. Physiol. 259 1990 G802 G806
117. F.T. Kokke T. Elsawy U. Bengtsson J.J. Wasmuth J.E. Wang C.M. Tse M. Donowitz S.R. Brant A NHE3-related pseudogene is on human chromosome 10; The functional gene maps to 5p15.3 Mamm. Genome 7 1996 235 236
118. + exchanger activation during shrinkage of human neutrophils J. Biol. Chem. 272 1997 17303 17311
119. + exchanger NHE3 isoforms is regulated by the phosphatidylinositol 3-kinase pathway J. Biol. Chem. 273 1998 20828 20836
120. + exchanger NHE3 activity by CAMP-dependent protein kinase J. Biol. Chem. 272 1997 28672 28678
121. K. Laghmani P. Borensztein P. Ambuhl M. Froissart M. Bichara O.W. Moe R.J. Alpern M. Paillard Chronic metabolic acidosis enhances NHE3 protein abundance and transport activity in the rat thick ascending limb by increasing NHE3 mRNA J. Clin. Invest. 99 1997 24 30
122. K. Laghmani R. Chambrey M. Froissart M. Bichara M. Paillard P. Borensztein Adaption of NHE3 in the rat thick ascending limb: Effects of high sodium intake and metabolic alkalosis Am. J. Physiol. 276 1999 F18 F26
123. G. Lamprecht U. Seidler M. Classen Intracellular pH-regulating ion transport mechanisms in parietal cell basolateral membrane vesicles Am. J. Physiol. 265 1993 G903 G910
124. G. Lamprecht E.J. Weinman C.H. Yun The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3 J. Biol. Chem. 273 1998 29972 29978
125. + exchanger isoforms by P2 receptors in the rat submandibular gland duct J. Physiol. 513 1998 341 357
126. + exchangers stably expressed in a fibroblast cell line J. Biol. Chem. 268 1993 25527 25535
127. + exchanger isoform NHE3 are involved in stimulation and inhibition by protein kinases/growth factors J. Biol. Chem. 270 1995 13716 13725
128. + exchange Proc. Natl. Acad. Sci. USA 93 1996 12631 12636
129. + exchanger isoforms J. Biol. Chem. 271 1996 22604 22610
130. J. Loffing M. Lotscher B. Kaissling J. Biber H. Murer M. Seikaly R.J. Alpern M. Baum O.W. Moe Renal Na/H exchanger NHE3 and Na-PO4 cotransporter NaPi-2 protein expression in glucocorticoid excess and deficient states J. Am. Soc. Nephrol. 9 1998 1560 1567
131. M. Lotscher B. Kaissling J. Biber H. Murer M. Levi Role of microtubules in the rapid regulation of renal phosphate transport in response to acute alterations in dietary phosphate content J. Clin. Invest. 99 1997 1302 1312
132. G.L. Lukacs G. Segal N. Kartner S. Grinstein F. Zhang Constitutive internalization of cystic fibrosis transmembrane conductance regulator occurs via clathrin-dependent endocytosis and is regulated by protein phosphorylation Biochem. J. 328 1997 353 361
133. + exchange by platelet-derived growth factor involves phosphatidylinositol 3-kinase and phospholipase C gamma J. Biol. Chem. 269 1994 30734 30739
134. + exchange isoform NHE3 regulates basal canine ileal Na+ absorption in vivo Gastroenterology 112 1997 174 183
135. + exchange in canine ileal absorption Dig. Dis. Sci. 41 1996 654 659
136. + exchanger NHE2 Am. J. Physiol 277 1999 G383 G390
137. + antiporter in trout red blood cells J. Exp. Biol. 200 1997 353 360
138. + exchangers NHE2 and NHE3 in intestinal epithelial cell line C2/bbe Am. J. Physiol. 275 1998 C693 C701
139. + exchanger NHE-3 J. Clin. Invest. 96 1995 2187 2194
140. B. Mrkic C.M. Tse J. Forgo C. Helmle-Kolb M. Donowitz H. Murer Identification of PTH-responsive Na/H-exchanger isoforms in a rabbit proximal tubule cell line (RKPC-2) Pflugers Arch. 424 1993 377 384
141. − reabsorption in renal collecting duct of NHE-3 deficient mouse: A compensatory response Am. J. Physiol. 276 1999 F914 F921
142. +-ATPase J. Biol. Chem. 272 1997 26145 26152
143. + exchanger, NHE3 Gastroenterology 110 1996 A349
144. + exchanger isoforms NHE2 and NHE3: An effect opposite to that on NHEL Am. J. Physiol. 270 1996 G431 G441
145. S.K. Nath R. Kambadur C.H. Yun M. Donowitz C.M. Tse NHE2 contains subdomains in the COON terminus for growth factor and protein kinase regulation Am. J. Physiol. 276 1999 C873 C882
146. + exchanger isoforms Am. J. Physiol. 268 1995 C283 C296
147. + exchanger isoforms (NHEI and NHE3) in polarized epithelial cell lines J. Cell. Sci. 109 1996 929 939
148. + exchanger J. Biol. Chem. 273 1998 6951 6959
149. K. Opleta-Madsen J. Hardin D.G. Gall Epidermal growth factor upregulates intestinal electrolyte and nutrient transport Am. J. Physiol. 260 1999 G807 G814
150. J. Orlowski Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger J. Biol. Chem. 268 1993 16369 16377
151. + exchangers of mammalian cells J. Biol. Chem. 272 1997 22373 22376
152. + exchanger that confer sensitivity to pharmacological antagonists J. Biol. Chem. 271 1996 19922 19927
153. + exchanger NHE-1 and two structurally related proteins J. Biol. Chem. 267 1992 9331 9339
154. + Novartis Found. Symp. 221 1999 183 196
155. + exchanger isoforms in rat parotid acinar and ductal cells Am. J. Physiol. 276 1999 G470 G478
156. Y. Peng O.W. Moe T. Chu P.A. Preisig M. Yanagisawa R.J. Alpern ETB receptor activation leads to activation and phosphorylation of NHE3 Am. J. Physiol. 276 1999 C938 C945
157. + exchange (NHE4) in cells of the macula densa J. Am. Soc. Nephrol. 9 1998 A52
158. A. Pfeifer A. Aszodi U. Seidler P. Ruth F. Hofmann R. Fassler Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II Science 274 1996 2082 2086
159. + exchanger isoform NHE4 Am. J. Physiol. 275 1998 F510 F517
160. + antiporter in rat proximal tubule bicarbonate absorption J. Clin. Invest. 80 1987 970 978
161. + exchange in apical membrane vesicles of rat colon J. Biol. Chem. 265 1990 8408 8414
162. V.M. Rajendran J. Geibel H.J. Binder Chloride-dependent NaH exchange. A novel mechanism of sodium transport in colonic crypts J. Biol. Chem. 270 1995 11051 11054
163. V.M. Rajendran J. Geibel H.J. Binder Role of C1 channels in Cl-dependent NaH exchange Am. J. Physiol. 276 1999 G73 G78
164. + exchanger. J. Biol. Chem. 266, 2739–2745
165. D. Reczek M. Berryman A. Bretscher Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family J. Cell. Biol. 139 1997 169 179
166. ++/calmodulin-mediated process J. Clin. Invest. 82 1988 1091 1097
167. + antiporter J. Membr. Biol. 108 1989 207 215
168. + antiporter is a glycoprotein of 110 kDa phosphorylated by growth factors in quiescent cells Science 247 1990 723 726
169. + exchanger, NHEI, by phosphorylating a set of common sites J. Biol. Chem. 266 1991 19166 19171
170. /H+ antiporter Cell 56 1989 271 280
171. + exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion J. Clin. Invest. 101 1998 1243 1253
172. + exchanger Nature Genet. 19 1998 282 285
173. + exchanger subtype 3 in various cell types Pflugers Arch. 436 1998 797 800
174. + exchanger isoform NHE 1–4 mRNA in different epithelial cell types of rat and rabbit gastric mucosa Gastroenterology 110 1997 A285
175. + Exchanger 1996 Chapman & Hall NYL 102 122
176. + exchanger using chymotryptic cleavage Am. J. Physiol. 275 1998 C431 C439
177. + exchange in hypertension and in diabete—Facts and hypotheses Basic Res. Cardiol. 91 1996 179 190
178. i cells: Inhibition of endogenous NHE-3 and regulation by hypertonicity J. Membr. Biol. 151 1996 261 268
179. + exchanger interacts with mammalian heat shock protein Biochemistry 34 1995 10412 10420
180. + exchanger in sodium absorption by the rabbit gallbladder Pflugers Arch. 432 1996 791 796
181. 3 cotransport in rat renal cortex J. Clin. Invest. 86 1990 1076 1083
182. 3 cotransport in rabbit kidney proximal tubules J. Clin. Invest. 90 1992 211 218
183. + exchanger isoform NHE-3 in rabbit and canine kidney Biochim. Biophys. Acta 1195 1994 89 95
184. + exchange in renal proximal tubule cells J. Biol. Chem. 269 1994 15613 15618
185. 3 in kidney proximal tubules J. Membr. Biol. 144 1995 209 216
186. + exchangers in health and disease processes J. Invest. Med. 43 1995 419 430
187. + exchanger isoforms NHE-2 and NHE-1 in inner medullary collecting duct cells: Expression, functional localization, and differential regulation J. Biol. Chem. 269 1994 27973 27978
188. + exchange activity, blocks NHE-3 transport to the membrane, and increases NHE-3 mRNA expression in LLC-PK1 cells J. Lab. Clin. Med. 127 1996 565 573
189. + exchanger isoform NHE3 in LLC-PK1 cells Kidney Int. 53 1998 423 431
190. + exchanger isoforms in inner segment of inner medullary collecting duct J. Membr. Biol. 164 1998 293 300
191. + exchanger isoform 2 (NHE2) is expressed in the apical membrane of the medullary thick ascending limb J. Membr. Biol. 160 1997 85 90
192. K. Szaszi L. Buday A. Kapus Shrinkage-induced protein tyrosine phosphorylation in Chinese hamster ovary cells J. Biol. Chem. 272 1997 16670 16678
193. C. Szpirer J. Szpirer M. Riviere G. Levan J. Orlowski Chromosomal assignment of four genes encoding Na/H exchanger isoforms in human and rat Mamm. Genome 5 1994 153 159
194. + exchanger in enzyme secretion from rat pancreatic acinar cells J. Membr. Biol. 152 1996 195 205
195. + exchanger isoform (NHE-3) J. Biol. Chem. 267 1992 9340 9346
196. + exchanger gene family J. Membr. Biol. 135 1993 93 108
197. + exchanger (NHE3): Resistance to amiloride and inhibition by protein kinase C Proc. Natl. Acad Sci. USA 90 1993 9110 9114
198. + exchanger-2 is an O-linked but not an N-linked sialoglycoprotein Biochemistry 33 1994 12954 12961
199. + exchanger isoform (NHE2) J. Biol. Chem. 268 1993 11917 11924
200. + exchanger EMBO. J. 10 1991 1957 1967
201. T. Tominaga D.L. Barber NaH exchange acts downstream of RhoA to regulate integrin-induced cell adhesion and spreading Mol. Biol. Cell. 9 1998 2287 2303
202. T. Tominaga T. Ishizaki S. Narumiya D.L. Barber p160Rock mediates RhoA activation of NaH exchange Embo. J. 17 1998 4712 4722
203. T. Voyno-Yasenetskaya B.R. Conklin R.L. Gilbert R. Hooley H.R. Bourne D.L. Barber G alpha 13 stimulates Na/H exchange J. Biol. Chem. 269 1994 4721 4724
204. 2+ regulation-defective J. Biol. Chem. 269 1994 13710 13715
205. + exchanger isoform 1 (NHEl). Evidence for an additional mechanism not requiring direct phosphorylation J. Biol. Chem. 269 1994 5583 5588
206. +-sensing” Proc. Natl. Acad. Sci. USA 89 1992 2424 2428
207. + exchanger NHEI through sequence-specific interaction Biochemistry 36 1997 12854 12861
208. 2+ responsiveness to the apical isoform NHE3 J. Biol. Chem. 270 1995 26460 26465
209. + exchanger NHEL J. Biol. Chem. 275 2000 7542 7949
210. + exchangers Physiol. Rev. 77 1997 51 74
211. + exchanger Am. J. Physiol. 269 1995 C392 C402
212. S. Wang P.J. Raab W.B. Guggino M. Li Peptide binding consensus of the NHEFR-PDZI domain matches the C-terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR) FEBS Lett. 427 1998 103 108
213. T. Wang C.L. Yang T. Abbiati P.J. Schultheis G.E. Shull G. Giebisch P.S. Aronson Mechanism of proximal tubule bicarbonate absorption in NHE3 null mice Am. J. Physiol. 277 1999 F298 302
214. + exchanger J. Biol. Chem. 268 1993 11925 11928
215. + exchange J. Biol. Chem. 274 1999 7841 7847
216. E.J. Weinman D. Steplock M. Donowitz S. Shenolikar NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for CAMP-mediated phosphorylation and inhibition of NHE3 Biochemistry 39 2000 6123 6129
217. + exchanger requires a dissociable phosphoprotein cofactor J. Clin. Invest. 92 1993 1781 1786
218. + exchanger J. Clin. Invest. 95 1995 2143 2149
219. + exchanger NHE3 activity by protein kinase C: Role of NHE3 phosphorylation Am. J. Physiol. 276 1999 C1205 C1217
220. + exchange Am. J. Physiol. 274 1998 C1261 C1272
221. + exchange J. Biol. Chem. 271 1996 32749 32752
222. Y. Yamaji O.W. Moe R.T. Miller R.J. Alpern Acid activation of immediate early genes in renal epithelial cells J. Clin. Invest. 94 1994 1297 1303
223. Y. Yamaji H. Tsuganezawa O.W. Moe R.J. Alpem Intracellular acidosis activates c-Src Am. J. Physiol. 272 1997 C886 C893
224. Y. Yamaji M. Amemiya A. Cano P.A. Preisig R.T. Miller O.W. Moe R.J. Alpem Overexpression of Csk inhibits acid-induced activation of NHE3 Proc. Natl. Acad. Sci. USA 92 1995 6274 6278
225. + channel Science 251 1991 939 942
226. + exchanger isoform 3 stably expressed in fibroblasts by fibroblast growth factor and phorbol esters is not through changes in phosphorylation of the exchanger J. Biol. Chem. 272 1997 18473 18480
227. + exchanger isoform NHE3 in proximal tubules induced by acute and chronic hypertension Am. J. Physiol. 275 1998 F565 F575
228. + exchanger isoforms NHE2 and NHE3 in rat proximal tubule during acute hypertension J. Am. Soc. Nephrol. 6 1995 218A
229. + exchange activity in cultured opossum kidney cells Am. J. Physiol. 258 1990 F333 F338
230. F.H. Yu G.E. Shull J. Orlowski Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient Chinese hamster ovary cells J. Biol. Chem. 268 1993 25536 25541
231. + exchanger NHE3 and the cytoskeletal protein ezrin J. Biol. Chem. 273 1998 25856 25863
232. + exchanger, NHE3, requires an associated regulatory protein Proc. Natl. Acad. Sci. USA 94 1997 3010 3015
233. + exchangers: An epithelial membrane-bound N-terminal domain requires an epithelial cytoplasmic C-terminal domain for regulation by protein kinases Proc. Natl. Acad. Sci. USA 92 1995 10723 10727
234. + exchanger isoform J. Biol. Chem. 268 1993 206 211
235. + exchanger isoform (NHE-2) Biochem. Biophys. Res. Commun. 193 1993 532 539
236. + exchanger gene structure and function studies Am. J. Physiol. 269 1995 G1 G11
237. + antiporter in rat renal brush-border membrane J. Biol. Chem. 236 1988 13683 13691
238. Y. Zhang C.E. Magyar J.M. Norian N.H. Holstein-Rathlou A.K. Mircheff A.A. McDonough Reversible effects of acute hypertension on proximal tubule sodium transporters Am. J. Physiol. 274 1998 C1090 C1100
239. Y. Zhang J.M. Norian C.E. Magyar N.H. Holstein-Rathlou A.K. Mircheff A.A. McDonough In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition Am. J. Physiol. 276 1999 F711 F719
240. H. Zhao M.R. Wiederkehr L. Fan R.L. Collazo L.A. Crowder O.W. Moe Acute inhibition of Na/H exchanger NHE-3 by cAMP. Role of protein kinase A and NHE-3 phosphoserines 552 and 605 J. Biol. Chem. 274 1999 3978 3987
241. + exchanger NHE3 has 11 membrane spanning domains and a cleaved signal peptide. Topology analysis using in vitro transcription/translation (XXXX) Biochemistry 2000 in Press
242. + exchanger (NHE3) is dependent on the presence but not the phosphorylation of NHERF J. Biol. Chem. 274 1999 24753 24758