Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II

Science

Volumn 274, Issue 5295, 1996, Pages 2082-2086

  Pfeifer, Alexander ^a   Aszódi, Attila ^b   Seidler, Ursula ^c   Ruth, Peter ^a   Hofmann, Franz ^a   Fässler, Reinhard ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP DEPENDENT PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL TYPE; CONTROLLED STUDY; DWARFISM; ELECTROLYTE TRANSPORT; ENCHONDRAL OSSIFICATION; ENZYME ACTIVATION; ESCHERICHIA COLI; GROWTH PLATE; INTESTINE SECRETION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SMOOTH MUSCLE RELAXATION;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; BACTERIAL TOXINS; BODY WATER; BONE DEVELOPMENT; CROSSES, GENETIC; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DIARRHEA; DWARFISM; ENTEROTOXINS; FEMALE; GENE DELETION; GROWTH PLATE; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED C57BL; OSTEOGENESIS; SIGNAL TRANSDUCTION;

ANIMALIA; ESCHERICHIA COLI;

EID: 0030452310     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.274.5295.2082     Document Type: Article

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30. We thank K. Kühn for his advice; M. Walter, M. Cuba, and I. Blumenstein for their help in the Ussing chamber experiments; K. Doerr, S. Kamm, and S. Benkert for technical assistance; and P. Klatt for help in quantifying the total body fat of the mice. Supported by grants from the Deutsche Forschungs Gemeinschaft, Bundesministerium für Forschung und Technologie, and Fonds der Chemie. R.F. was supported by the Hermann and Lilly Schilling Stiftung.