Tissue distribution of Na+/H+ exchanger isoforms NHE2 and NHE4 in rat intestine and kidney

American Journal of Physiology - Cell Physiology

Volumn 273, Issue 5 42-5, 1997, Pages

  Bookstein, Crescence ^a   Xie, Yue ^a   Rabenau, Karen ^a   Musch, Mark W ^a   Mcswine, Rebbecca L ^a   Rao, Mrinalini C ^b   Chang, Eugene B ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Ion transport; Sodium proton exchanger

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); MESSENGER RNA;

ANIMAL CELL; ARTICLE; IN SITU HYBRIDIZATION; INTESTINE; KIDNEY; NONHUMAN; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RNA ANALYSIS; SODIUM ABSORPTION; SODIUM TRANSPORT; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0030666773     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1997.273.5.c1496     Document Type: Article

References (26)

1. + exchanger isoforms and their regulation by thyroid hormone. Am. J. Physiol. 270 (Cell Physiol. 39): C585-C592, 1996.
2. + exchanger isoform NHE-4 and localization in rat hippocampus. Am. J. Physiol. 271 (Cell Physiol. 40): C1629-C1638, 1996.
3. Bookstein, C., M. W. Musch, A. DePaoli, Y. Xie, M. Villereal, M. C. Rao, and E. B. Chang. A unique sodium-hydrogen exchange isoform (NHE-4) of the inner medulla of the rat kidney is induced by hyperosmolarity. J. Biol. Chem. 269: 29704-29709, 1994.
4. + exchanger mRNAs in rat medullary thick ascending limb. Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol. 37): F1224-F1228, 1995.
5. + exchanger (NHE-2). Proc. Natl. Acad. Sci. USA 90: 3938-3942, 1993.
6. + antiporter. J. Biol. Chem. 261: 14614-14620, 1986.
7. Glisin, V., R. Crkvenjakov, and C. Byus. Ribonucleic acid isolated by cesium chloride centrifugation. Biochemistry 13: 2633-2637, 1974.
8. Hoogerwerf, W. A., S. C. Tsao, O. Devuyst, S. A. Levine, C. H. Yun, J. W. Yip, M. E. Cohen, P. D. Wilson, A. J. Lazenby, C.-M. Tse, and M. Donowitz. NHE2 and NHE3 are human and rabbit intestinal brush-border proteins. Am. J. Physiol. 270 (Gastrointest. Liver Physiol. 33): G29-G41, 1996.
9. + exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role in cell proliferation. J. Biol. Chem. 269: 23544-23552, 1994.
10. Keeton, T., S. Burk, and G. Shull. Alternative splicing of exons encoding the calmodulin-binding domains and C termini of plasma membrane Ca(2+)-ATPase isoforms 1, 2, 3, and 4. J. Biol. Chem. 268: 2740-2748, 1993.
11. Klanke, C. A., Y. R. Su, D. R. Callen, Z. Wang, P. Meneton, N. Baird, R. A. Kandasamy, J. Orlowski, B. E. Otterud, M. Leppert, G. E. Shull, and A. G. Menon. Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1. Genomics 25: 615-622, 1995.
12. - exchanger. Cloning of a cardiac AE3 cDNA, organization of the AE3 gene, and identification of an alternative transcription initiation site. J. Biol. Chem. 267: 7927-7935, 1992.
13. Modyanov, N., K. E. Petrukhin, V. E. Sverdlov, A. V. Grishin, M. Y. Orlova, M. B. Kostina, O. I. Makarevich, N. E. Broude, G. S. Monastyrskaya, and E. D. Sverdlov. The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase. FEBS Lett. 278: 91-94, 1991.
14. Nakazoto, H., and M. Edmonds. Purification of messenger RNA and heterogeneous nuclear RNA containing poly (a) sequences. Methods Enzymol. 29: 431-443, 1974.
15. Orlowski, J., R. A. Kandasamy, and G. E. Shull. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. J. Biol. Chem. 267: 9331-9339, 1992.
16. Payne, J. A., and I. B. Forbush. Alternatively spliced isoforms of the putative renal Na-K-Cl cotransporter are differentially distributed within the rabbit kidney. Proc. Natl. Acad. Sci. USA 91: 4544-4548, 1994.
17. + antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH. Proc. Natl. Acad. Sci. USA 81: 4833-4837, 1984.
18. + antiporter. Cell 56: 271-280, 1989.
19. + exchanger isoforms NHE-2 and NHE-1 in inner medullary collecting duct cells. Expression, functional localization, and differential regulation. J. Biol. Chem. 269: 27973-27978, 1994.
20. Szpirer, C., J. Szpirer, M. Riviere, G. Levan, and J. Orlowski. Chromosomal assignment of four genes encoding Na/H exchanger isoforms in human and rat. Mamm. Genome 5: 153-159, 1994.
21. Tse, C. M., S. R. Brant, M. S. Walker, J. Pouyssegur, and M. Donowitz. Cloning and sequencing of a rabbit cDNA encoding an intestinal and kidney-specific Na+/H+ exchanger isoform (NHE-3). J. Biol. Chem. 267: 9340-9346, 1992.
22. + exchanger-2 is an O-linked but not an N-linked sialoglycoprotein. Biochemistry 33: 12954-12961, 1994.
23. + exchanger isoform (NHE-2). J. Biol. Chem. 268: 11917-11924, 1993.
24. + antiporter cytoplasmic domain mediates growth factor signals and controls "H(+)-sensing." Proc. Natl. Acad. Sci. USA 89: 2424-2428, 1992.
25. Wang, Z., J. Orlowski, and G. E. Shull. Primary structure and functional expression of a novel gastrointestinal isoform of the rat Na/H exchanger. J. Biol. Chem. 268: 11925-11928, 1993.
26. Yu, F. H., G. E. Shull, and J. Orlowski. Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient Chinese hamster ovary cells. J. Biol. Chem. 268: 25536-25541, 1993.