Chronic metabolic acidosis increases NHE3 protein abundance in rat kidney

American Journal of Physiology - Renal Fluid and Electrolyte Physiology

Volumn 271, Issue 4 40-4, 1996, Pages

  Ambühl, Patrice M ^b   Amemiya, Morimasa ^b   Danczkay, Monika ^b   Lötscher, Marius ^b   Kaissling, Brigitte ^b   Moe, Orson W ^b   Preisig, Patricia A ^b   Alpern, Robert J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b NONE

Author keywords

Apical membrane; Proximal tubule; Sodium hydrogen antiporter; Thick ascending limb

Indexed keywords

ANTIPORTER; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP);

ACID BASE BALANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; ENZYME ACTIVITY; IMMUNOBLOTTING; MALE; METABOLIC ACIDOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; RNA ANALYSIS; SODIUM ABSORPTION;

ACIDOSIS; ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CHRONIC DISEASE; IMMUNOHISTOCHEMISTRY; KIDNEY; MALE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SODIUM-HYDROGEN ANTIPORTER; TISSUE DISTRIBUTION;

EID: 0029999581     PISSN: 03636127     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajprenal.1996.271.4.f917     Document Type: Article

References (30)

1. Akiba, T., V. K. Rocco, and D. G. Warnock. Parallel adaptation of the rabbit renal cortical sodium/proton antiporter and sodium/bicarbonate cotransporter in metabolic acidosis and alkalosis. J. Clin. Invest. 80: 308-315, 1987.
2. Alpern, R. J., M. G. Cogan, and F. C. Rector, jr. Effects of extracellular fluid volume and plasma bicarbonate concentration on proximal acidification in the rat. J. Clin. Invest. 71: 736-746, 1983.
3. Alpern, R. J., and F. C. Rector, jr. Renal acidification mechanisms. In: The Kidney, edited by B. M. Brenner. Philadelphia, PA: Saunders, 1996, p. 408-471.
4. Amemiya, M., J. Loffing, M. Lötscher, B. Kaissling, R. J. Alpern, and O. W. Moe. Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb. Kidney Int. 48: 1206-1215, 1995.
5. Amemiya, M., Y. Yamaji, A. Cano, O. W. Moe, and R. J. Alpern. Acid incubation increases NHE3 mRNA abundance in OKP cells. Am. J. Physiol. 269 (Cell Physiol. 38): C126-C133, 1995.
6. Baum, M., D. Biemesderfer, D. Gentry, and P. Aronson. Maturation of rabbit renal cortical NHE-3 and NHE-1: effect of glucocorticoids (Abstract). J. Am. Soc. Nephrol. 5: 247, 1994.
7. Baum, M., A. Cano, and R. J. Alpern. Glucocorticoids stimulate Na/H antiporter in OKP cells. Am. J. Physiol. 264 (Renal Fluid Electrolyte Physiol. 33): F1027-F1031, 1993.
8. Biemesderfer, D., J. Pizzonia, M. Exner, R. Reilly, P. Igarashi, and P. S. Aronson. NHE3: an Na/H exchanger isoform of the renal brush border. Am. J. Physiol. 265 (Renal Fluid Electrolyte Physiol. 34): F736-F742, 1993.
9. Borensztein, P., K. Laghmani, M. Froissart, M. Bichara, and M. Paillard. Chronic adaptation of NHE-3 mRNA and transport activity in rat medullary thick ascending limb (MTAL): effects of metabolic acidosis and high Na intake (Abstract). J. Am. Soc. Nephrol. 6: 305, 1995.
10. Cano, A., R. T. Miller, R. J. Alpern, and P. Preisig. Angiotensin II stimulation of Na/H antiporter activity is cAMP-independent in OKP cells. Am. J. Physiol. 266 (Cell Physiol. 35): C1603-C1608, 1994.
11. Chan, Y. L., and G. Giebisch. Relationship between sodium and bicarbonate transport in the rat proximal convoluted tubule. Am. J. Physiol. 240 (Renal Fluid Electrolyte Physiol. 9): F222-F230, 1981.
12. 2+ -dependent pathway in OKP cells. J. Clin. Invest. 97: 1454-1462, 1996.
13. Cohn, D. E., S. Klahr, and M. R. Hammerman. Metabolic acidosis and parathyroidectomy increase Na/H exchange in brush border vesicles. Am. J. Physiol. 245 (Renal Fluid Electrolyte Physiol. 14): F217-F222, 1983.
14. Fort, P., L. Marty, M. Piechaezyk, S. EI Sabrouty, C. Dani, P. Jeanteur, and J. M. Blanchard. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic Acids Res. 13: 1431-1442, 1985.
15. 4 transport in rat MTAL: effects of chronic metabolic acidosis and Na intake. Am. J. Physiol. 258 (Renal Fluid Electrolyte Physiol. 27): F1345-F1353, 1990.
16. Horie, S., O. Moe, A. Tejedor, and R. J. Alpern. Preincubation in acid medium increases Na/H antiporter activity in cultured renal proximal tubule cells. Proc. Natl. Acad. Sci. USA 87: 4742-4745, 1990.
17. 1 renal epithelial cells. Am. J. Physiol. 263 (Renal Fluid Electrolyte Physiol. 32): F83-F88, 1992.
18. Kinsella, J. L., T. Cujkit, and B. Sactor. Na-H exchange activity in renal brush border membrane vesicles in response to metabolic acidosis: the role of glucocorticoids. Proc. Natl. Acad. Sci. USA 81: 630-634, 1984.
19. 2 absorption. Am. J. Physiol. 249 (Renal Fluid Electrolyte Physiol. 18): F62-F68, 1985.
20. Levi, M., L. A. McDonald, P. A. Preisig, and R. J. Alpern. Chronic K depletion stimulates rat renal brush-border membrane Na-citrate cotransporter. Am. J. Physiol. 261 (Renal Fluid Electrolyte Physiol. 30): F767-F773, 1991.
21. 2- cotransport. Proc. Natl. Acad. Sci. USA 90: 8073-8077, 1993.
22. Moe, O. W., R. T. Miller, S. Horie, A. Cano, P.A. Preisig, and R. J. Alpern. Differential regulation of Na/H antiporter by acid in renal epithelial cells and fibroblasts. J. Clin. Invest. 88: 1703-1708, 1991.
23. + exchanger isoforms. Am. J. Physiol. 268 (Cell Physiol. 37): C283-C296, 1995.
24. Orlowski, J., R. A. Kandasamy, and G. E. Shull. Molecular cloning of putative members of the Na/H exchanger gene family. J. Biol. Chem. 267: 9331-9339, 1992.
25. Pollock, A. S., D. G. Warnock, and G. J. Strewler. Parathyroid hormone inhibition of Na-H antiporter activity in a cultured renal cell line. Am. J. Physiol. 250 (Renal Fluid Electrolyte Physiol. 19): F217-F225, 1986.
26. 3 symporter in the rat proximal convoluted tubule. J. Clin. Invest. 82: 1445-1453, 1988.
27. Preisig, P. A., H. E. Ives, E. J. Cragoe, R. J. Alpern, and F. C. Rector, jr. Role of the Na/H antiporter in rat proximal tubule bicarbonate absorption. J. Clin. Invest. 80: 970-978, 1987.
28. + antiporter activity in proximal tubule brush border vesicles from rabbits with metabolic acidosis. Am. J. Physiol. 247 (Renal Fluid Electrolyte Physiol. 16): F339-F343, 1984.
29. Tse, C. M., S. R. Brant, M. S. Walker, J. Pouyssegur, and M. Donowitz. Cloning and sequencing of a rabbit cDNA encoding an intestinal and kidney-specific Na/H exchanger isoform (NHE3). J. Biol. Chem. 267: 9340-9346, 1992.
30. Wu, M.-H., D. Biemesderfer, G. Giebisch, and P. S. Aronson. Role of NHE3 in mediating renal brush bordeer Na-H exchange: adaptation to acidosis (Abstract). J. Am. Soc. Nephrol. 6: 318, 1995.