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P.L. Ogro, M.E. Lamm, J. Bienenstock, J. Mestecky, W. Strober, & J.R. McGhee. San Diego: Academic Press
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Elson, C.O.1
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0032118427
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Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation
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Snapper S.B., Rosen F.S., Mizoguchi E., Cohen P., Khan W., Liu C-H, Hagemann T.L., Kwan S-P, Ferrini R., Davidson L.et al. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity. 9:1998;81-91.
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Snapper, S.B.1
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Davidson, L.10
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4
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0031811879
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Inflammatory bowel disease-like enteritis caecitis in a senescence accelerated mouse P1/Yit strain
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Matsumoto S., Okabe Y., Setoyama H., Takayama K., Ohtsuka J., Funahashi H., Imaoka A., Okada Y., Umesaki Y Inflammatory bowel disease-like enteritis caecitis in a senescence accelerated mouse P1/Yit strain. Gut. 43:1998;71-78.
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5
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0032921746
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A synthetic mimetic of CD4 is able to suppress disease in a rodent model of immune cells
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Okamoto S., Watanabe M., Yamazaki M., Yajima T., Hayashi T., Ishii H., Mukai M., Yamada T., Noriaki W., Jameson B.A., Hibi T. A synthetic mimetic of CD4 is able to suppress disease in a rodent model of immune cells. Eur J Immunol. 29:1999;355-366.
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Okamoto, S.1
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6
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0029156966
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Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis
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Simpson S.J., Mizoguchi E., Allen D., Bhan A.K., Terhorst C Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur J Immunol. 25:1995;2618-2625.
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Simpson, S.J.1
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7
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0030666959
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Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice
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Mizoguchi A., Mizogucni E., Smith R.N., Preffer F.I., Bhan A.K. Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice. J Exp Med. 186:1997;1749-1756.
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Mizoguchi, A.1
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Modulation of epithelial cell growth by intraepithelial γδ T cells
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0033559891
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+ T cells in immunodeficient adoptive hosts depends on their state of activation, IL-12 responsiveness, and CD45RB surface phenotype
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lo subset have colitis-inducing potential.
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lo subset have colitis-inducing potential.
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Claesson, M.H.1
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Leithäuser, F.7
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10
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0033103805
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Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
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A fascinating paper, which shows that TNF is a major factor in the development of CD-like pathology that is consistent with clinical observations in humans.
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Kontoyiannis D., Pasparakis M., Pizarro T.T., Cominelli F., Kollias G. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity. 10:1999;387-398. A fascinating paper, which shows that TNF is a major factor in the development of CD-like pathology that is consistent with clinical observations in humans.
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Immunity
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Kontoyiannis, D.1
Pasparakis, M.2
Pizarro, T.T.3
Cominelli, F.4
Kollias, G.5
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11
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0032955192
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Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: Amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein
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Higgins L.M., McDonald S.A., Whittle N., Crockett N., Shields J.G., MacDonald T.T Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein. J Immunol. 162:1999;486-493.
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Higgins, L.M.1
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MacDonald, T.T.6
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12
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0031760741
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Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis
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Mackay F., Browning J., Lawton P., Shah S.A., Comiskey M., Bhan A.K., Mizoguichi E., Terhorst C., Simpson S.J. Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis. Gastroenterology. 115:1998;1464-1475.
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MacKay, F.1
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Mizoguichi, E.7
Terhorst, C.8
Simpson, S.J.9
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13
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0032718352
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Anti interleukin-12 treatment regulates apoptosis of T helper 1 T cells in experimental colitis
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This paper provides a potential mechanism for the beneficial role of blocking IL-12 in colitis models.
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Fuss I.J., Marth T., Neurath M.F., Pearlstein G.R., Jain A., Strober W. Anti interleukin-12 treatment regulates apoptosis of T helper 1 T cells in experimental colitis. Gastroenterology. 117:1999;1078-1088. This paper provides a potential mechanism for the beneficial role of blocking IL-12 in colitis models.
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Gastroenterology
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Fuss, I.J.1
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+ T cells that respond to bacterial antigens
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+ T cells that respond to bacterial antigens. J Immunol. 162:1999;1884-1888.
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Wirtz, S.1
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Lehr, H.A.6
Galle, P.R.7
Neurath, M.F.8
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15
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0032550312
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T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon γ expression by T cells
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This paper examines IL-12-mediated pathways of colitis induction and shows that IFN-γ-dependent and -independent mechanisms probably exist.
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Simpson S.J., Shah S., Comiskey M., de Jong Y.P., Wang B., Mizoguchi E., Bhan A.K., Terhorst C. T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon γ expression by T cells. J Exp Med. 187:1998;1225-1234. This paper examines IL-12-mediated pathways of colitis induction and shows that IFN-γ-dependent and -independent mechanisms probably exist.
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J Exp Med
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Simpson, S.J.1
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Comiskey, M.3
De Jong, Y.P.4
Wang, B.5
Mizoguchi, E.6
Bhan, A.K.7
Terhorst, C.8
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16
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0032530697
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IL-12, but not IFN-γ, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice
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Davidson N.J., Hudak S.A., Lesley R.E., Menon S., Leach M.W., Rennick D.M. IL-12, but not IFN-γ, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice. J Immunol. 161:1998;3143-3149.
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Davidson, N.J.1
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Rennick, D.M.6
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18
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0032884525
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Protection of experimentally induced colitis by an interleukin-2-IgG2b fusion protein in mice
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Stallmach A., Wittig B., Giese T., Pfister K., Hoffman J.C., Bulfone-Paus S., Kunzendorf U., Meuer S.C., Zeitz M. Protection of experimentally induced colitis by an interleukin-2-IgG2b fusion protein in mice. Gastroenterology. 117:1999;866-876.
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Stallmach, A.1
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Bulfone-Paus, S.6
Kunzendorf, U.7
Meuer, S.C.8
Zeitz, M.9
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19
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0032536530
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The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor
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This is a new model of colitis that is the result of knocking out a newly targeted component of the IL-10 receptor.
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Spencer S.D., DiMarco F., Hooley J., Pitts-Meek S., Bauer M., Ryan A.M., Sordat B., Gibbs V.C., Aguet M. The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. J Exp Med. 187:1998;571-578. This is a new model of colitis that is the result of knocking out a newly targeted component of the IL-10 receptor.
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J Exp Med
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Spencer, S.D.1
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Pitts-Meek, S.4
Bauer, M.5
Ryan, A.M.6
Sordat, B.7
Gibbs, V.C.8
Aguet, M.9
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20
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0029995799
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Experimental granulomatous colitis in mice is abrogated by induction of TGF-γ-mediated oral tolerance
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Neurath M.F., Fuss I., Kelsall B.L., Presky D.H., Waegell W., Strober W. Experimental granulomatous colitis in mice is abrogated by induction of TGF-γ-mediated oral tolerance. J Exp Med. 183:1996;2605-2616.
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Neurath, M.F.1
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Strober, W.6
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23
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0032538915
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Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4
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This is another new model of colitis that appears to be due to excess Th2 cytokines such as IL-4.
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Boirivant M., Fuss I.J., Chu A., Strober W. Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med. 188:1998;1929-1939. This is another new model of colitis that appears to be due to excess Th2 cytokines such as IL-4.
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J Exp Med
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Boirivant, M.1
Fuss, I.J.2
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Strober, W.4
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24
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0033583477
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Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses
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This paper investigates the role of Th1 and Th2 cytokines in TNBS-induced colitis and provides evidence in support of a pathogenic role for both. Furthermore, this study suggests that polarized cytokine responses promote different types of pathology with varying kinetics.
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Dohi T., Fujihashi K., Rennert P.D., Iwatani K., Kiyono H., McGhee J.R. Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses. J Exp Med. 189:1999;1169-1179. This paper investigates the role of Th1 and Th2 cytokines in TNBS-induced colitis and provides evidence in support of a pathogenic role for both. Furthermore, this study suggests that polarized cytokine responses promote different types of pathology with varying kinetics.
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J Exp Med
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Dohi, T.1
Fujihashi, K.2
Rennert, P.D.3
Iwatani, K.4
Kiyono, H.5
McGhee, J.R.6
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26
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0033034365
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Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
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In this model, the loss of Stat3 in myeloid cells leads to an activated phenotype of macrophages and consequently colitis, raising the possibility that primary defects in macrophages and other myeloid cells may be sufficient to initiate colitis.
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Takeda K., Kaisho T., Terada N., Akira S. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity. 10:1999;34-49. In this model, the loss of Stat3 in myeloid cells leads to an activated phenotype of macrophages and consequently colitis, raising the possibility that primary defects in macrophages and other myeloid cells may be sufficient to initiate colitis.
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Immunity
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Takeda, K.1
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The intestinal epithelial cell: Immunological aspects
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Christ A., Blumberg R.S. The intestinal epithelial cell: immunological aspects. Springer Semin Immunopathol. 18:1997;449-461.
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Christ, A.1
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Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin
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Hermiston, M.L.1
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0032534043
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A novel model of inflammatory bowel disease: Mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis
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This new model of colitis supports other studies indicating a potential central role of intestinal epithelial cell dysfunction in the pathogenesis of colitis.
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Panwala C.M., Jones J.C., Viney J.L. A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. J Immunol. 161:1998;5733-5744. This new model of colitis supports other studies indicating a potential central role of intestinal epithelial cell dysfunction in the pathogenesis of colitis.
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Panwala, C.M.1
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30
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0032540266
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Fulminant jenuno-ileitis following ablation of enteric glia in adult transgenic mice
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This is an extremely interesting study showing that interactions between nerve cells, immune cells and the vasculature may be important to mucosal homeostasis and the generation of colitis.
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Bush T.G., Savidge T.C., Freeman T.C., Cox H.J., Campbell E.A., Mucke L., Johnson M.H., Sofroniew M.V. Fulminant jenuno-ileitis following ablation of enteric glia in adult transgenic mice. Cell. 93:1998;189-201. This is an extremely interesting study showing that interactions between nerve cells, immune cells and the vasculature may be important to mucosal homeostasis and the generation of colitis.
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Cell
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Bush, T.G.1
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Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion
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Stuber, E.1
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0031253731
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TGF-β production regulates the development of the 2,4,6-trinitrophenol-conjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2-deficient mice
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Ludviksson B.R., Ehrhardt R.O., Strober W. TGF-β production regulates the development of the 2,4,6-trinitrophenol-conjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2-deficient mice. J Immunol. 159:1997;3622-3628.
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Consequences of Fas-ligand and perforin expression by colon T cells in a mouse model of inflammatory bowel disease
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Simpson S.J., de Jon Y.P., Shah S.A., Comiskey M., Wang B., Spielman J.A., Podack E.R., Mizoguchi E., Bhan A.K., Terhorst C. Consequences of Fas-ligand and perforin expression by colon T cells in a mouse model of inflammatory bowel disease. Gastroenterology. 115:1998;849-855.
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Simpson, S.J.1
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CD95 (APO-1/Fas)-mediated apoptosis in colon epithelial cells: A possible role in ulcerative colitis
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Strater J., Wellisch I., Riedl S., Walczak H., Koretz K., Tandara A., Krammer P.H., Moller P. CD95 (APO-1/Fas)-mediated apoptosis in colon epithelial cells: a possible role in ulcerative colitis. Gastroenterology. 113:1997;160-167.
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Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin α4/β7
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Curative treatment of an experimentally induced colitis by a CD44 variant V7-specific antibody
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VCAM-1 and ICAM-1 mediate leukocyte-endothelial cell adhesion in rat experimental colitis
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Sams M., Panés J., Ardite E., Elizalde J.I., Arce Y., Elena M., Palacín A., Fernández-Checa J.C., Andeerson D.C., Lobb R., Piqué J.M. VCAM-1 and ICAM-1 mediate leukocyte-endothelial cell adhesion in rat experimental colitis. Gastroenterology. 116:1999;874-883.
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Sams, M.1
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41
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0033557687
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Expression of the neutrophil chemokine KC in the colon of mice with enterocolitis and by intestinal epithelial cell lines: Effects of flora and proinflammatory cytokines
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Song F., Ito K., Denning T.L., Kuninger D., Papaconstantinou J., Gourley W., Klimpel G., Balish E., Hokanson J., Ernst P.B. Expression of the neutrophil chemokine KC in the colon of mice with enterocolitis and by intestinal epithelial cell lines: effects of flora and proinflammatory cytokines. J Immunol. 162:1999;2275-2280.
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Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice
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Contractor N.V., Bassiri H., Reya T., Park A.Y., Baumgart D.C., Wasik M.A., Emerson S.G., Carding S.R. Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice. J Immunol. 160:1998;385-394.
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T cell specificity and cross reactivity toward enterobacteria, bacteriodes, bifidobacterium, and antigens from resident intestinal flora in humans
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