A convergent approach to cryptophycin 52 analogues: Synthesis and biological evaluation of a novel series of fragment A epoxides and chlorohydrins

Journal of Medicinal Chemistry

Volumn 46, Issue 14, 2003, Pages 2985-3007

  Al Awar, Rima S ^a   Ray, James E ^a   Schultz, Richard M ^a   Andis, Sherri L ^a   Kennedy, Joseph H ^a   Moore, Richard E ^b   Liang, Jian ^b   Golakoti, Trimurtulu ^b   Subbaraju, Gottumukkala V ^b   Corbett, Thomas H ^c  

^a ELI LILLY AND COMPANY   (United States)

^b UNIVERSITY OF HAWAII   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHLOROHYDRIN; ANTIMITOTIC AGENT; ARENASTATIN A; CREMOPHOR; CRYPTOPHYCIN 52; DEPSIPEPTIDE; DNA FRAGMENT; PACLITAXEL; VINBLASTINE; VINCRISTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYANOBACTERIUM; DERIVATIZATION; DRUG ISOLATION; DRUG POTENCY; DRUG SCREENING; EPOXIDATION; GROWTH INHIBITION; MALE; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PANCREAS ADENOCARCINOMA; SOLUBILITY; SYNTHESIS; WITTIG REACTION;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; DEPSIPEPTIDES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LACTAMS; LACTONES; MALE; MICE; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0038460847     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0203884     Document Type: Article

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80. We thank Dr. Michael Martinelli and his group in Chemical Process R & D Division of Lilly Research Laboratories for the supply of Cryptophycin 53.