The preparation and Wittig condensations of C-4 thiazole phosphonium methylides

Tetrahedron Letters

Volumn 37, Issue 7, 1996, Pages 983-986

  Williams, David R ^a   Brooks, Dawn A ^a   Moore, Jimmie L ^b   Stewart, Andrew O ^b  

^a INDIANA UNIVERSITY   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

phosphonium salts; thiazole synthesis

Indexed keywords

PHOSPHONIUM DERIVATIVE; THIAZOLE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0030035001     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(95)02358-5     Document Type: Article

References (33)

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32. Our phosphonium salts 4 - 7 were fully characterized by proton and carbon NMR, infrared, and high-resolution mass spectrometry (CI).
33. 5 thiazole ring hydrogens were individually distinguished in proton NMR spectra for each E/Z pair (located in the range δ = 6.8 to 7.3). E-olefins showed the expected large vicinal coupling (J = 16 Hz).