Characterization of the interaction of cryptophycin 1 with tubulin: Binding in the vinca domain, competitive inhibition of dolastatin 10 binding, and an unusual aggregation reaction

Cancer Research

Volumn 56, Issue 19, 1996, Pages 4398-4406

  Bai, Ruoli ^a   Schwartz, Robert E ^b   Kepler, John A ^c   Pettit, George R ^d   Hamel, Ernest ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c RTI INTERNATIONAL   (United States)

^d ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYPTOPHYCIN 1; DEPSIPEPTIDE; DOLASTATIN; MICROTUBULE ASSOCIATED PROTEIN; TUBULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL GROWTH; COMPETITIVE INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; STOICHIOMETRY;

ANTIFUNGAL AGENTS; BINDING, COMPETITIVE; DEPSIPEPTIDES; LIGANDS; MACROMOLECULAR SUBSTANCES; MICROSCOPY, ELECTRON; OLIGOPEPTIDES; PEPTIDES, CYCLIC; PROTEIN BINDING; TUBULIN;

EID: 0029759374     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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