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Volumn 56, Issue 21, 2000, Pages 3339-3351

Synthesis of 1-aza-cryptophycin 1, an unstable cryptophycin. An unusual skeletal rearrangement

Author keywords

Antitumour compounds; Depsipeptides; Natural products; Rearrangements

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; CRYPTOPHYCIN 1; CRYPTOPHYCIN DERIVATIVE; DEPSIPEPTIDE; MANDELIC ACID; NATURAL PRODUCT; UNCLASSIFIED DRUG;

EID: 0034685738     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(00)00255-6     Document Type: Article
Times cited : (44)

References (38)
  • 31
    • 0003514816 scopus 로고
    • Eds.; Wiley: New York
    • Fieser, L. F., Fieser, M., Eds.; Wiley: New York, 1967; Vol. 1, p 191.
    • (1967) , vol.1 , pp. 191
    • Fieser, L.F.1    Fieser, M.2
  • 33
    • 84991418878 scopus 로고    scopus 로고
    • 2
    • 2.
  • 34
    • 84991420904 scopus 로고    scopus 로고
    • The reaction does not proceed in scrupulously anhydrous THF. It is necessary to add a small amount of water to the solvent in order for the reaction to proceed
    • The reaction does not proceed in scrupulously anhydrous THF. It is necessary to add a small amount of water to the solvent in order for the reaction to proceed.
  • 35
    • 84991412861 scopus 로고    scopus 로고
    • This compound is not very stable, being prone to cyclise to a THF compound with a trace of base, and is used immediately. If the compound is to be stored, it must be kept in solution at -10°C
    • This compound is not very stable, being prone to cyclise to a THF compound with a trace of base, and is used immediately. If the compound is to be stored, it must be kept in solution at -10°C.
  • 36
    • 84991422566 scopus 로고    scopus 로고
    • This compound it not very stable, being prone to cyclise to a THF compound with a trace of base, and is used immediately. If the compound is to be stored, it should be kept in solution and kept cold
    • This compound it not very stable, being prone to cyclise to a THF compound with a trace of base, and is used immediately. If the compound is to be stored, it should be kept in solution and kept cold.
  • 37
    • 84991412860 scopus 로고    scopus 로고
    • Although 21 could be isolated in an acid/base extraction, the yield was low, which suggests that partitioning between the two phases was incomplete. The use of crude material results in a good overall yield of 23
    • Although 21 could be isolated in an acid/base extraction, the yield was low, which suggests that partitioning between the two phases was incomplete. The use of crude material results in a good overall yield of 23.
  • 38
    • 84991422568 scopus 로고    scopus 로고
    • Air must be rigorously excluded from this reaction
    • Air must be rigorously excluded from this reaction.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.