Halohydrin analogues of cryptophycin 1: Synthesis and biological activity

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 15, 1998, Pages 1959-1962

  Georg, Gunda I ^a   Ali, Syed M ^a   Stella, Valentine J ^a   Waugh, Wanda N ^a   Himes, Richard H ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMITOTIC AGENT; CRYPTOPHYCIN 1; CRYPTOPHYCIN DERIVATIVE; HALOHYDRIN DERIVATIVE; PACLITAXEL; TUBULIN; UNCLASSIFIED DRUG; VINBLASTINE;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; DRUG ACTIVITY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; MICROTUBULE ASSEMBLY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; DEPSIPEPTIDES; HALF-LIFE; INDANS; MELANOMA, EXPERIMENTAL; MICROTUBULES; MITOSIS; PEPTIDES, CYCLIC; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0032483101     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00356-4     Document Type: Article

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16. 5 For the halohydrins a downfield shift of approximately 1 ppm and an increase in coupling constants were observed for the corresponding halohydrin protons. Compound 2: 4.01 (Ha, dd; 9.6 and 1.9 Hz), 4.60 (Hb, d; 9.9 Hz). Compound 3: 4.19 (Ha, d; 9.8 Hz), 4.73 (Hb, d; 9.9 Hz). Compound 4: 4.32 (Ha, d; 10 Hz), 4.88 (Hb, d; 10 Hz).