Aberrant DNA methylation precedes loss of heterozygosity on chromosome 16 in chronic hepatitis and liver cirrhosis

Cancer Letters

Volumn 148, Issue 1, 2000, Pages 73-80

  Kanai, Yae ^a   Ushijima, Saori ^a   Tsuda, Hitoshi ^a   Sakamoto, Michiie ^a   Hirohashi, Setsuo ^a  

^a NATIONAL CANCER CENTER   (Japan)

Author keywords

Chronic hepatitis; DNA hypermethylation; E cadherin; Hepatocellular carcinoma; Liver cirrhosis; Loss of heterozygosity

Indexed keywords

UVOMORULIN;

ADULT; AGED; ALLELE; ARTICLE; CHROMOSOME 16; CHRONIC HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; FEMALE; GENE LOCUS; GENETIC STABILITY; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; INCIDENCE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER HISTOLOGY; MALE; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; PROMOTER REGION;

ADULT; AGED; ALLELES; CADHERINS; CARCINOMA, HEPATOCELLULAR; CHROMOSOMES, HUMAN, PAIR 16; DNA METHYLATION; FEMALE; GENES, TUMOR SUPPRESSOR; HEPATITIS, CHRONIC; HUMANS; LIVER; LIVER CIRRHOSIS; LIVER NEOPLASMS; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; PRECANCEROUS CONDITIONS; PROMOTER REGIONS (GENETICS);

EID: 0033988602     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(99)00316-X     Document Type: Article

References (37)

1. Jones P.A., Laird P.W. Cancer epigenetics comes of age. Nat. Genet. 21:1999;163-167.
2. Gama-Sosa M.A., Slagel V.A., Trewyn R.W., Oxenhandler R., Kuo K.C., Gehrke C.W., Ehrlich M. The 5-methylcytosine content of DNA from human tumors. Nucl. Acids Res. 11:1983;6883-6894.
3. Kautiamen T.L., Jones P.A. DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture. J. Biol. Chem. 261:1986;1594-1598.
4. Makos M., Nelkin B.D., Lerman M.I., Latif F., Zbar B., Baylin S.B. Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer. Proc. Natl. Acad. Sci. USA. 89:1992;1929-1933.
5. Makos M., Nelkin B.D., Reiter R.E., Gnarra J.R., Brooks J., Isaacs W., Linehan M., Baylin S.B. Regional DNA hypermethylation at D17S5 precedes 17p structural changes in the progression of renal tumors. Cancer Res. 53:1993;2719-2722.
6. Makos M., Nelkin B.D., Chazin V.R., Cavenee W.K., Brodeur G.M., Baylin S.B. DNA hypermethylation is associated with 17p allelic loss in neural tumors. Cancer Res. 53:1993;2715-2718.
7. Kanai Y., Ushijima S., Tsuda H., Sakamoto M., Sugimura T., Hirohashi S. Aberrant DNA methylation on chromosome 16 is an early event in hepatocarcinogenesis. Jpn. J. Cancer Res. 87:1996;1210-1217.
8. Eguchi K., Kanai Y., Kobayashi K., Hirohashi S. DNA hypermethylation at the D17S5 locus in non-small cell lung cancers: its association with smoking history. Cancer Res. 57:1997;4913-4915.
9. Kanai Y., Ushijima S., Ochiai A., Eguchi K., Hui A.M., Hirohashi S. DNA hypermethylation at the D17S5 locus is associated with gastric carcinogenesis. Cancer Lett. 122:1998;135-141.
10. Kanai Y., Hui A.M., Sun L., Ushijima S., Sakamoto M., Tsuda H., Hirohashi S. DNA hypermethylation at the D17S5 locus and reduced HIC-1 mRNA expression are associated with hepatocarcinogenesis. Hepatology. 29:1999;703-709.
11. Vachtenheim J., Horakova I., Novotna H. Hypomethylation of CCGG sites in the 3′ region of H-ras protooncogene is frequent and is associated with H-ras allelic loss in non-small cell lung cancer. Cancer Res. 54:1994;1145-1148.
12. Shen J.C., Rideout W.M. III, Jones P.A. High frequency mutagenesis by a DNA methyltransferase. Cell. 71:1992;1073-1080.
13. Sakai T., Toguchida J., Ohtani N., Yandell D.W., Rapaport J.M., Dryja T.P. Allele-specific hypermethylation of the retinoblastoma tumor-suppresser gene. Am. J. Hum. Genet. 48:1991;880-888.
14. Herman J.G., Latif F., Weng Y., Lerman M.I., Zbar B., Liu S., Samid D., Duan D.-S.R., Gnarra J.R., Linehan W.M., Baylin S.B. Silencing of the VHL tumor-suppresser gene by DNA methylation in renal carcinoma. Proc. Natl. Acad. Sci. USA. 91:1994;9700-9704.
15. Yoshiura K., Kanai Y., Ochiai A., Shimoyama Y., Sugimura T., Hirohashi S. Silencing of the E-cadherin invasion-suppresser gene by CpG methylation in human carcinomas. Proc. Natl. Acad. Sci. USA. 92:1995;7416-7419.
16. Merlo A., Herman J.G., Mao L., Lee D.J., Gabrielson E., Burger P.C., Baylin S.B., Sidransky D. 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppresser p16/CDKN2/MTS1 in human cancers. Nat. Med. 1:1995;686-692.
17. Kanai Y., Ushijima S., Hui A.M., Ochiai A., Tsuda H., Sakamoto M., Hirohashi S. The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas. Int. J. Cancer. 71:1997;355-359.
18. Kokalj-Vokac N., Almeida A., Viegas-Pequignot E., Jeanpierre M., Malfoy B., Dutrillaux B. Specific induction of uncoiling and recombination by azacytidine in classical satellite-containing constitutive heterochromatin. Cytogenet. Cell Genet. 63:1993;11-15.
19. Chen R.Z., Pettersson U., Beard C., Jackson-Grusby L., Jaenisch R. DNA hypomethylation leads to elevated mutation rates. Nature. 395:1998;89-93.
20. Wales M.M., Biel M.A., el Deiry W., Nelkin B.D., Issa J.P., Cavenee W.K., Kuerbitz S.J., Baylin S.B. p53 activates expression of HIC-1, a new candidate tumor suppresser gene on 17p13.3. Nat. Med. 1:1995;570-577.
21. Tsuda H., Hirohashi S., Shimosato Y., Terada M., Hasegawa H. Clonal origin of atypical adenomatous hyperplasia of the liver and clonal identity with hepatocellular carcinoma. Gastroenterology. 95:1988;1664-1666.
22. Yasui H., Hino O., Ohtake K., Machinami R., Kitagawa T. Clonal growth of hepatitis B virus-integrated hepatocytes in cirrhotic liver nodule. Cancer Res. 52:1992;6810-6814.
23. Sun L., Hui A.M., Kanai Y., Sakamoto M., Hirohashi S. Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis. Jpn. J. Cancer Res. 88:1997;1165-1170.
24. Tsuda H., Zhang W., Shimosato Y., Yokota J., Terada M., Sugimura T., Miyamura T., Hirohashi S. Allelic loss on chromosome 16 associated with progression of human hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA. 87:1990;6791-6794.
25. Mansouri A., Spurr N., Goodfellow P.N., Kemler R. Characterization and chromosomal location of the gene encoding the human cell adhesion molecule uvomorulin. Differentiation. 38:1988;67-71.
26. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science. 251:1991;1451-1455.
27. Sundaresan V., Ganly P., Hasleton P., Rudd R., Sinha G., Bleehen N.M., Rabbitts P. p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus. Oncogene. 7:1992;1989-1997.
28. O'Connell P., Pekkel V., Fuqua S., Osborne C.K., AlIred D.C. Molecular genetic studies of early breast cancer evolution. Breast Cancer Res. Treat. 32:1994;5-12.
29. Kishimoto Y., Shiota G., Wada K., Kitano M., Nakamoto K., Kamisaki Y., Suou T., Itoh T., Kawasaki H. Frequent loss in chromosome 8p loci in liver cirrhosis accompanying hepatocellular carcinoma. J. Cancer Res. Clin. Oncol. 122:1996;585-589.
30. Ashida K., Kishimoto Y., Nakamoto K., Wada K., Shiota G., Hirooka Y., Kamisaki Y., Itoh T., Kawasaki H. Loss of heterozygosity of the retinoblastoma gene in liver cirrhosis accompanying hepatocellular carcinoma. J. Cancer Res. Clin. Oncol. 123:1997;489-495.
31. Kishimoto Y., Shiota G., Kamisaki Y., Wada K., Nakamoto K., Yamawaki M., Kotani M., Itoh T., Kawasaki H. Loss of the tumor suppresser p53 gene at the liver cirrhosis stage in Japanese patients with hepatocellular carcinoma. Oncology. 54:1997;304-310.
32. Noguchi M., Furuya S., Takeuchi T., Hirohashi S. Modified formalin and methanol fixation methods for molecular biological and morphological analyses. Pathol. Int. 47:1997;685-691.
33. Sambrook J., Fritsch E.F., Maniatis T. Molecular cloning: a laboratory manual. 1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. pp. E3-E4.
34. Kessler C., Neumaier P.S., Wolf W. Recognition sequences of restriction endonucleases and methylases: a review. Gene. 33:1985;1-102.
35. Weissenbach J., Gyapay G., Dib C., Vignal A., Morissette J., Millasseau P., Vaysseix G., Lathrop M. A second-generation linkage map of the human genome. Nature. 359:1992;794-801.
36. Ahuja N., Mohan A.L., Li Q., Stolker J.M., Herman J.G., Hamilton S.R., Baylin S.B., Issa J.P. Association between CpG island methylation and microsatellite instability in colorectal cancer. Cancer Res. 57:1997;3370-3374.
37. Lengauer C., Kinzler K.W., Vogelstein B. DNA methylation and genetic instability in colorectal cancer cells. Proc. Natl. Acad. Sci. USA. 94:1997;2545-2550.