Detection of hypermethylation of the p16INK4A gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus

Gut

Volumn 48, Issue 3, 2001, Pages 372-377

  Kaneto, H ^a   Satoh, T ^a,b   Karino, Y ^b   Toyota, J ^a,b   Satoh, M ^a   Endo, T ^a   Omata, M ^c   Imai, K ^a   Sasaki, S ^a   Yamamoto, H ^a   Itoh, F ^a   Toyota, M ^a   Suzuki, H ^a   Ozeki, I ^a   Iwata, N ^a   Ohmura, T ^b  

^a SAPPORO MEDICAL UNIVERSITY   (Japan)

^b Sapporo Kosei General Hospital   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Hepatitis virus infection; Hepatocarcinogenesis; Hypermethylation; Methylation specific PCR; p16; Preneoplastic diseases

Indexed keywords

PROTEIN P16;

ADULT; ARTICLE; CHRONIC HEPATITIS; CLINICAL ARTICLE; DISEASE ASSOCIATION; DNA METHYLATION; FEMALE; HEPATITIS B; HEPATITIS C; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CIRRHOSIS; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

ADULT; AGED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; FEMALE; GENE EXPRESSION; GENES, P16; HEPATITIS B, CHRONIC; HEPATITIS C, CHRONIC; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PRECANCEROUS CONDITIONS; PROMOTER REGIONS (GENETICS);

EID: 0035056507     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.48.3.372     Document Type: Article

References (31)

1. Hepatocellular carcinoma: Recent progress
2. Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3
3. Hepatitis C virus core protein cooperate with rats and transform primary rat embryo fibroblast to tumorigenic phenotype
4. Hepatitis C virus core from two different genotypes has an oncogenic potential but is not sufficient for transforming primary rat embryo fibroblasts in cooperation with the H-ras oncogene
5. Overexpression of cyclin D1 enhances gene amplification
6. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16 INK4a
7. Cell-cycle regulators and cancer
8. Inactivation of p16FNK4 in hepatocellular carcinoma
9. INK4A gene in liver cancer
10. Frequency of mutation and deletion of the tumor suppressor gene CDKN2A (MTS1/p16) in hepatocellular carcinoma from an Australian population
11. INK4 (MTS1) gene occur in a subset of patients with hepatocellular carcinoma
12. Mutational study of p16CDKN2/MTS1/INK4A and p57KIP2 genes in hepatocellular carcinoma
13. INK4A gene alterations in hepatocellular carcinoma
14. INK4 is inactivated by extensive CpG methylation in human hepatocellular carcinoma
15. Homozygous deletions of the CDKN2 gene and loss of heterozygosity of 9p in primary hepatocellular carcinoma
16. Alterations of CDKN2 (p16/MTS1) exon 2 in human hepatocellular carcinoma
17. Alteration in DNA methylation: A fundamental aspect of neoplasia
18. Cancer epigenetics comes of age
19. Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients
20. Infrequent mutations and no methylation of CDKN2A (P16/MTS1) and CDKN2B (p15/MTS2) in hepatocellular carcinoma in Taiwan
21. Aberrant methylation of p16 (INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis
22. Hypermethylation of p16INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis
23. Hypermethylation of the CDKN2/p16 promoter during neoplastic progression in Barrett's esophagus
24. Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: Loss of intranuclear expression
25. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
26. The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines
27. INK4: Involvement early and often in gastrointestinal malignancies
28. Inactivation of p16 in human mammary epithelial cells by CpG island methylation
29. Infection with human immunodeficiency virus type 1 upregulates DNA methylation of the gamma interferon (IFN-gamma) promoter and subsequent downregulation of IFN-gamma production
30. Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis
31. Methylation profiling of CpG islands in human breast cancer cells