Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma

Cancer Research

Volumn 62, Issue 23, 2002, Pages 6820-6822

  Sato, Fumiaki ^a   Shibata, David ^a   Harpaz, Noam ^b   Xu, Yan ^a   Yin, Jing ^a   Mori, Yuriko ^a   Wang, Suna ^a   Olaru, Andreea ^a   Deacu, Elena ^a   Selaru, Florin M ^a   Kimos, Martha C ^a   Hytiroglou, Prodromos ^b   Young, Joanne ^c   Leggett, Barbara ^c   Gazdar, Adi F ^d   Toyooka, Shinichi ^d   Abraham, John M ^a   Meltzer, Stephen J ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; PROTEIN; PROTEIN HPP1; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER STAGING; CARCINOGENESIS; CLINICAL ARTICLE; COLON ADENOCARCINOMA; COLORECTAL CARCINOMA; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; DYSPLASIA; GENE EXPRESSION; GENE FUNCTION; HUMAN; HUMAN TISSUE; METHYLATION; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULCERATIVE COLITIS;

COLITIS, ULCERATIVE; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; DNA METHYLATION; HUMANS; MEMBRANE PROTEINS; MICROSATELLITE REPEATS; NEOPLASM PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0036894567     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Lashner, B. A., Silverstein, M.D., and Hanauer, S.B. Hazard rates for dysplasia and cancer in ulcerative colitis. Results from a surveillance program. Dig. Dis. Sci. 34; 1536-1541, 1989
2. Ekbom, A., Helmick, C., Zack, M., and Adami, H. O. Ulcerative colitis and colorectal cancer. A population-based study. N. Engl. J. Med., 323: 1228-1233, 1990.
3. Harpaz, N., and Talbot, I. C. Colorectal cancer in idiopathic inflammatory bowel disease. Semin. Diagn. Pathol., 13: 339-357, 1996.
4. Fearon, E. R., and Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell, 61: 759-767, 1990.
5. Young, J., Biden, K. G., Simms, L. A., Huggard, P., Karamatic, R., Eyre, H. J., Sutherland, G. R., Herath, N., Barker, M., Anderson, G. J., Fitzpatrick, D. R., Ramm, G. A., Jass, J. R., and Leggett, B. A. HPP1: A transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers. Proc. Natl. Acad. Sci. USA, 98: 265-270, 2001.
6. Meltzer, S. J., Yin, J., Manin, B., Rhyu, M. G., Cottrell, J., Hudson, E., Redd, J. L., Krasna, M. J., Abraham, J. M., and Reid, B. J. Microsatellite instability occurs frequently and in both diploid and aneuploid cell populations of Barrett's-associated esophageal adenocarcinomas. Cancer Res., 54: 3379-3382, 1994.
7. Boynton, R. F., Blount, P. L., Yin, J., Brown, V. L., Huang, Y., Tong, Y., McDaniel, T., Newkirk, C., Resau, J. H., Raskind, W. H., et al. Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers. Proc. Natl. Acad. Sci. USA, 89: 3385-3388, 1992.
8. Eads, C. A., Lord, R. V., Wickramasinghe, K., Long, T. I., Kurumboor, S. K., Bernstein, L., Peters, J. H., DeMeester, S. R., DeMeester, T. R., Skinner, K. A., and Laird, P. W. Epigenetic patterns in the progression of esophageal adenocarcinoma. Cancer Res., 61: 3410-3418, 2001.
9. Bender, C. M., Gonzalgo, M. L., Gonzales, F. A., Nguyen, C. T., Robertson, K. D., and Jones, P. A. Roles of cell division and gene transcription in the methylation of CpG islands. Mol. Cell. Biol., 19: 6690-6698, 1999.
10. Herman, J. G., Graff, J. R., Myohanen, S., Nelkin, B. D., and Baylin, S. B. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA, 93: 9821-9826, 1996.
11. ARF gene in ulcerative colitis-associated colorectal carcinogenesis. Cancer Res., 62: 1148-1151, 2002.
12. Issa, J. P., Ahuja, N., Toyota, M., Bronner, M. P., and Brentnall, T. A. Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Res., 61: 3573-3577, 2001.
13. Hsieh, C. J., Klump, B., Holzmann, K., Borchard, F., Gregor, M., and Porschen, R. Hypermethylation of the p16INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis. Cancer Res., 58: 3942-3945, 1998.
14. Wheeler, J. M., Kim, H. C., Efstathiou, J. A., Ilyas, M., Mortensen, N. J., and Bodmer, W. F. Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer. Gut, 48: 367-371, 2001.
15. Fleisher, A. S., Esteller, M., Harpaz, N., Leytin, A., Rashid, A., Xu, Y., Liang, J., Stine, O. C., Yin, J., Zou, T. T., Abraham, J. M., Kong, D., Wilson, K. T., James, S. P., Herman, J. G., and Meltzer, S. J. Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1. Cancer Res., 60: 4864-4868, 2000.
16. Tamura, G., Yin, J., Wang, S., Fleisher, A. S., Zou, T., Abraham, J. M., Kong, D., Smolinski, K. N., Wilson, K. T., James, S. P., Silverberg, S. G., Nishizuka, S., Terashima, M., Motoyama, T., and Meltzer, S. J. E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas. J. Natl. Cancer Inst. (Bethesda), 92: 569-573, 2000.
17. Eads, C. A., Lord, R. V., Kurumboor, S. K., Wickramasinghe, K., Skinner, M. L., Long, T. I., Peters, J. H., DeMeester, T. R., Danenberg, K. D., Danenberg, P. V., Laird, P. W., and Skinner, K. A. Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma. Cancer Res., 60: 5021-5026, 2000.
18. Liang, G., Gonzales, F. A., Jones, P. A., Orntoft, T. F., and Thykjaer, T. Analysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2′-deoxycytidine. Cancer Res., 62: 961-966, 2002.
19. Uchida, T., Wada, K., Akamatsu, T., Yonezawa, M., Noguchi, H., Mizoguchi, A., Kasuga, M., and Sakamoto, C. A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells. Biochem. Biophys. Res. Commun., 266: 593-602, 1999.
20. Horie, M., Mitsumoto, Y., Kyushiki, H., Kanemoto, N., Watanabe, A., Taniguchi, Y., Nishino, N., Okamoto. T., Kondo, M., Mori, T., Noguchi, K., Nakamura, Y., Takahashi, E., and Tanigami, A. Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons. Genomics, 67: 146-152, 2000.