CD40-deficient dendritic cells producing interleukin-10, but not interleukin-12, induce T-cell hyporesponsiveness in vitro and prevent acute allograft rejection

Immunology

Volumn 98, Issue 2, 1999, Pages 159-170

  Gao, J X ^a   Madrenas, J ^a,b   Zeng, W ^a   Cameron, M J ^b   Zhang, Z ^a,b   Wang, J J ^a,b   Zhong, R ^a,b   Grant, D ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; GLYCOPROTEIN P 15095; INTERLEUKIN 10; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NEUTRALIZING ANTIBODY; RECOMBINANT INTERLEUKIN 12;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IRRADIATION; MALE; MIXED LEUKOCYTE CULTURE; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE ACTIVATION;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD40; CELLS, CULTURED; DENDRITIC CELLS; FLOW CYTOMETRY; GRAFT REJECTION; IMMUNE TOLERANCE; INTERLEUKIN-10; INTERLEUKIN-12; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS;

EID: 0032883173     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1999.00863.x     Document Type: Article

References (56)

1. 1. BANCHEREAU J. & STEINMAN R.M. (1998) Dendritic cells and the control of immunity. Nature 392, 245.
2. 2. PARIJS L.V. & ABBAS A.K. (1998) Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science 280, 243.
3. 3. SALLUSTO F. & LANZAVECCHIA A. (1999) Mobilizing dendritic cells for tolerance, priming, and chronic inflammation. J Exp Med 189, 611.
4. 4. RISSOAN M.-C., SOUMELIS V., KADOWAKI N. et al. (1999) Reciprocal control of T helper cell and dendritic cell differentiation. Science 283, 183.
5. 5. LINSLEY P.S. (1995) Distinct roles for CD28 and cytotoxic T lymphocyte-associated molecule-4 receptors during T cell activation. J Exp Med 182, 289.
6. 6. RESCIGNO M., WINZLER C., DELIA D., MUTINI C., LUTZ M. & RICCIARDI C.P. (1997) Dendritic cell maturation is required for initiation of the immune response. J Leukoc Biol 61, 415.
7. 7. GREWAL, I.S. & FLAVELL, R.A. (1996) The role of CD40 ligand in co-stimulation and T-cell activation. Immunol Rev 153, 85.
8. 8. MACKEY M.F., GUNN J.R., MALISZEWSKI C., KIKUTANI H., NOELLE R.J. & BARTH R.J. (1998) Dendritic cells require maturation via CD40 to generate protective antitumor immunity. J Immunol 161, 2094.
9. 9. FINKELMAN F.D., LEES A., BIRNBAUM R., GAUSE W.C. & MORRIS S.C. (1996) Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion. J Immunol 157, 1406.
10. 10. PALUCKA K.A., TAQUET N., SANCHEZ-CHAPUIS F. & GLUCKMAN J.C. (1998) Dendritic cells as the terminal stage of monocyte differentiation. J Immunol 160, 4587.
11. 11. LU L., WOO J., RAO A.S. et al. (1994) Propagation of dendritic cell progenitors from normal mouse liver using granulocyte/ macrophage colony-stimulating factor and their maturational development in the presence of type-1 collagen. J Exp Med 179, 1823.
12. 12. GEISSMANN F., PROST C., MONNET J.-P., DY M., BROUSSE N. & HERMINE O. (1998) Transforming growth factor-β1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans' cells. J Exp Med 187, 2417.
13. 13. WINZLER C., ROVERE P., RESCIGNO M. et al. (1997) Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures. J Exp Med 185, 317.
14. 14. HAUSSER G., LUDEWIG B., GELDERBLOM H.R., TSUNETSUGUYOKOTA Y., AKAGAWA K.S. & MEYERHANS A. (1997) Monocytederived dendritic cells represent a transient stage of differentiation in the myeloid lineage. Immunobiology 197, 534.
15. 15. SALLUSTO F. & LANZAVECCHIA A. (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 179, 1109.
16. + dendritic cells and tartrate-resistant acid phosphatase-positive ostcoclast-like multinucleated giant cells from human monocytes. Blood 88, 4029.
17. -) prolong cardiac allograft survival in nonimmunosuppressed recipients. Transplantation 62, 659.
18. 18. STEINBRINK K., WOLFL M., JONULETT H., KNOP J. & ENK A.H. (1997) Induction of tolerance by IL-10-treated dendritic cells. J Immunol 159, 4772.
19. 2, promote type-2 cytokine production in maturing human naive T helper cells. J Immunol 159, 28.
20. + T cells. J Exp Med 184, 19.
21. 21. ANTONYSAMY M.A., STEPTOE R.J., KHANNA A., RUDERT W.A., SUBBOTIN V.M. & THOMSON A.W. (1098) FIt-3 ligand increases microchimerism but can prevent the therapeutic effect of donor bone marrow in transiently immunosuppressed cardiac allograft recipients. J Immunol 160, 4106.
22. 22. SCHWARTZ R.H. (1996) Models of T cell anergy: is there a common molecular mechanism? J Exp Med 184, 1.
23. 23. MALVEY E.-N., TELANDER D.G., VANASEK T.L. & MUELLER D.L. (1998) The role of clonal anergy in the avoidance of autoimmunity: inactivation of autocrine growth without loss of effector function. Immumol Rev 165, 301.
24. 24. PEREZ V.L., PARUS L.V., BIUCKIANS A., ZHENG X.X., STROM T.B. & ABBAS A.K. (1997) Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6, 411.
25. 25. GAO J.X., MADRENAS J., ZENG W., ZHONG R. & GRANT D. (1997) Generation of dendritic cell-like antigen-presenting cells in long-term mixed leukocyte culture: phenotypic and functional studies. Immunology 91, 135.
26. 26. CAMERON M.J., ARREAZA G.A., ZUCKER P. et al. (1998) IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function. J Immunol 159, 4686.
27. 27. ZHANG Z., ZHU L., QUAN D. et al. (1996) Pattern of liver, kidney, heart, and intestine allograft rejection in different mouse strain combinations. Transplantation 62, 1267.
28. 28. BUSHELL A., PEARSON T.C., MORRIS P.J. & WOOD K.J. (1995) Donor-recipient microchimerism is not required for tolerance induction following recipient pretreatment with donor-specific transfusion and anti-CD4 antibody. Evidence of a clear role for short-term antigen persistence. Transplantation 59, 1367.
29. 29. MUELLER D.L. & JENKINS M.K. (1995) Molecular mechanisms underlying functional T-cell unresponsiveness. Curr Opin Immunol 7, 375.
30. 30. TRINCHERI G. (1995) Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 13, 251.
31. 31. RUTHERFORD M.S., WITSELL A. & SCHOOK L.B. (1993) Mechanisms generating functionally heterogeneous macrophages: chaos revisited. J Leukoc Biol 53, 602.
32. 32. CELLA M., SCHEIDEGGER D., PALMER L.K., LANE P., LANZAVECCHIA A. & ALBER G. (1996) Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 184, 747.
33. 33. YANG Y. & WILSON J.M. (1996) CD40 ligand-dependent T cell activation: requirement of B7 CD28 signaling through CD40. Science 273, 1862.
34. 34. MACKEY M.F., BARTH R.J. & NOELLE R.J. (1998) The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells. J Leukoc Biol 63, 418.
35. 35. KOCK F., STANZL U., JENNEWEIN P. et al. (1999) High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and donwregulation by IL-4 and IL-10. J Exp Med 184, 741.
36. 36. SURI R.M. & AUSTYN J.M. (1998) Bacterial lipopolysaccharide contamination of commercial collagen preparations may mediate dendritic cell maturation in culture. J Immunol Methods 214, 149.
37. 37. VERHASSELT V., BUELENS C., WILLEMS F., DE GROOTE D., HAEFFNER-CAVAILLON N. & GOLDMAN M. (1997) Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of co-stimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway. J Immunol 158, 2919.
38. - induce alloantigen-specific hyporesponsiveness in murine T lymphocytes. Transplantation 60, 1539.
39. 39. JENKINS M.K. (1992) The role of cell division in the induction of clonal anergy. Immunol Today 13, 69.
40. 40. VIDARD L., COLARUSSO L.J. & BENACERRAF B. (1994) Specific T-cell tolerance may be preceded by a primary response, Proc Natl Acad Sci USA 91, 5627.
41. 41. RISDON G., DADDY J., HORIE M. & BROXMEYER H.E. (1995) Alloantigen priming induces a state of unresponsiveness in human umbilical cord blood T cells. Proc Natl Acad Sci USA 92, 2413.
42. 42. BUELENS C., VERHASSELT V., DE GROOTE D., THIELEMANS K., GOLDMAN M. & WILLEMS F. (1997) Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by interleukin-10. Eur J Immunol 27, 1848.
43. 43. WILLEMS F.A., MARCHANT J.P., DELVILLE C. et al. (1994) Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur J Immunol 24, 1007.
44. 44. DING L., LINSLEY P.S., HUANG L.Y., GERMAIN R.N. & SHEVACH E.M. (1993) IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol 151, 1224.
45. 45. LEE H.H., DEMPSEY P.W., PARKS T.P., ZHU X., BALTIMORE D. & CHENG G. (1999) Specificities of CD40 signaling: involvement of TRAF2 in CD40-induced NF-kappaB activation and intercellular adhesion molecule-1 up-regulation. Proc Natl Acad Sci USA 96, 1421.
46. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389, 737.
47. 47. LOMBARDI G., SIDHU S., BATCHELOR R. & LECHLER R. (1994) Anergic T cells as suppressor cells in vitro. Science 264, 1587.
48. 48. TANCHOT C., LEMONNIER F.A., PERARNAU B., FREITAS A.A. & ROCHA B. (1997) Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276, 2057.
49. 49. ARNOLD B., SCHONRICH G. & HAMMERLING G.J. (1993) Multiple levels of peripheral tolerance. Immunol Today 14, 12.
50. 50. TAAMS L.S., VAN EDEN W. & WAUBEN M.H.M. (1999) Dose-dependent induction of distinct anergic phenotypes: multiple levels of T cell anergy. J Immunol 162, 1974.
51. 51. LOMEDICO P.T., GUBLER U., HELLMANN C.P. et al. (1984) Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. Nature 312, 458.
52. 52. GRAY P.W., GLAISTER D., CHEN E., GOEDDEL D.V. & PENNICA D. (1986) Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta. J Immunol 137, 3644.
53. 53. CHIU C.P., MOULDS C., COFFMAN R.L., RENNICK D. & LEE F. (1988) Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. Proc Natl Acad Sci USA 85, 7099.
54. 54. MOORE K.W., VIEIRA P., FIORENTINO D.F., TROUNSTINE M.L., KHAN T.A. & MOSMAN T.R. (1990) Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI [published erratum appears in Science 1990 October 26, 250 (4980): 494]. Science 248, 1230.
55. 55. WOLF S.F., TEMPLE P.A., KOBAYASHI M. et al. (1991) Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol 146, 3074.
56. 56. ALONSO S., MINTY A., BOURLET Y. & BUCKINGHAM M. (1986) Comparison of three actin-coding sequences in the mouse, evolutionary relationships between the actin genes of warm-blooded vertebrate. J Mol Evol 23, 11.