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Volumn 10, Issue 4, 2003, Pages 477-484

Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy

Author keywords

Alkylating drugs; Apoptosis; B CLL; Drug sensitivity; p53 mutation

Indexed keywords

ALKYLATING AGENT; ANTHRACYCLINE; ANTINEOPLASTIC AGENT; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; DNA; DOXORUBICIN; FLUDARABINE; GLUCOCORTICOID; MAFOSFAMIDE; METHYLPREDNISOLONE; PROTEIN P53; VINCA ALKALOID; VINCRISTINE;

EID: 0037850927     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401194     Document Type: Review
Times cited : (130)

References (54)
  • 1
    • 0037050253 scopus 로고    scopus 로고
    • The apoptosis promoting bcl-2 homologues bak and nbk/bik overcome drug resistance in mdr-1-negative and mdr-1-overexpressing breast cancer cell lines
    • Radetzki S, Kohne CH, von Haefen C, Gillissen B, Sturm I, Dörken B and Daniel PT (2002) The apoptosis promoting bcl-2 homologues bak and nbk/bik overcome drug resistance in mdr-1-negative and mdr-1-overexpressing breast cancer cell lines. Oncogene 21: 227-238
    • (2002) Oncogene , vol.21 , pp. 227-238
    • Radetzki, S.1    Kohne, C.H.2    von Haefen, C.3    Gillissen, B.4    Sturm, I.5    Dörken, B.6    Daniel, P.T.7
  • 3
    • 0035901938 scopus 로고    scopus 로고
    • Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cells with acquired drug resistance
    • Friedrich K, Wieder T, von Haefen C, Radetzki S, Schulze-Osthoff K, Jänicke R, Dörken B and Daniel PT (2001) Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cells with acquired drug resistance. Oncogene 20: 2749-2760
    • (2001) Oncogene , vol.20 , pp. 2749-2760
    • Friedrich, K.1    Wieder, T.2    von Haefen, C.3    Radetzki, S.4    Schulze-Osthoff, K.5    Jänicke, R.6    Dörken, B.7    Daniel, P.T.8
  • 4
    • 0037030465 scopus 로고    scopus 로고
    • Ceramide induces mitochondrial activation and apoptosis via a bax-dependent pathway in human carcinoma cells
    • von Haefen C, Wieder T, Gillissen B, Stärck L, Graupner V, Dörken B and Daniel PT (2002) Ceramide induces mitochondrial activation and apoptosis via a bax-dependent pathway in human carcinoma cells. Oncogene 21: 4009-4019
    • (2002) Oncogene , vol.21 , pp. 4009-4019
    • von Haefen, C.1    Wieder, T.2    Gillissen, B.3    Stärck, L.4    Graupner, V.5    Dörken, B.6    Daniel, P.T.7
  • 5
    • 0029928561 scopus 로고    scopus 로고
    • Apoptotic death of tumor cells correlates with chemosensitivity, independent of p53 or bcl-2
    • Wu GS and El-Deiry WS (1996) Apoptotic death of tumor cells correlates with chemosensitivity, independent of p53 or bcl-2. Clin. Cancer Res. 2: 623-633
    • (1996) Clin. Cancer Res. , vol.2 , pp. 623-633
    • Wu, G.S.1    El-Deiry, W.S.2
  • 6
    • 0033552638 scopus 로고    scopus 로고
    • Twenty years of p53 research: Structural and functional aspects of the p53 protein
    • May P and May E (1999) Twenty years of p53 research: structural and functional aspects of the p53 protein. Oncogene 18: 7621-7636
    • (1999) Oncogene , vol.18 , pp. 7621-7636
    • May, P.1    May, E.2
  • 8
    • 0028172868 scopus 로고
    • P53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies
    • Wattel E, Preudhomme C, Hecquet B, Vanrumbeke M, Quesnel B, Dervite I, Morel P and Fenaux P (1994) P53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies. Blood 84: 3148-3157
    • (1994) Blood , vol.84 , pp. 3148-3157
    • Wattel, E.1    Preudhomme, C.2    Hecquet, B.3    Vanrumbeke, M.4    Quesnel, B.5    Dervite, I.6    Morel, P.7    Fenaux, P.8
  • 9
  • 10
    • 0033832590 scopus 로고    scopus 로고
    • Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the bax/bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo
    • Prokop A, Wieder T, Sturm I, Essmann F, Seeger K, Wuchter C, Ludwig WD, Henze G, Dörken B and Daniel PT (2000) Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the bax/bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo. Leukemia 14: 1606-1613
    • (2000) Leukemia , vol.14 , pp. 1606-1613
    • Prokop, A.1    Wieder, T.2    Sturm, I.3    Essmann, F.4    Seeger, K.5    Wuchter, C.6    Ludwig, W.D.7    Henze, G.8    Dörken, B.9    Daniel, P.T.10
  • 11
    • 0034900902 scopus 로고    scopus 로고
    • The kiss of death: Promises and failures of death receptors and ligands in cancer therapy
    • Daniel PT, Sturm I, Wieder T and Schulze-Osthoff K (2001) The kiss of death: promises and failures of death receptors and ligands in cancer therapy. Leukemia 15: 1022-1032
    • (2001) Leukemia , vol.15 , pp. 1022-1032
    • Daniel, P.T.1    Sturm, I.2    Wieder, T.3    Schulze-Osthoff, K.4
  • 12
    • 0034520470 scopus 로고    scopus 로고
    • Dissecting the pathways to death
    • Daniel PT (2000) Dissecting the pathways to death. Leukemia 14: 2035-2044
    • (2000) Leukemia , vol.14 , pp. 2035-2044
    • Daniel, P.T.1
  • 13
    • 85047694961 scopus 로고    scopus 로고
    • Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia
    • Bosanquet AG, Sturm I, Wieder T, Essmann F, Bosanquet MI, Head DJ, Dörken B and Daniel PT (2002) Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia. Leukemia 16: 1035-1044
    • (2002) Leukemia , vol.16 , pp. 1035-1044
    • Bosanquet, A.G.1    Sturm, I.2    Wieder, T.3    Essmann, F.4    Bosanquet, M.I.5    Head, D.J.6    Dörken, B.7    Daniel, P.T.8
  • 15
    • 0344348993 scopus 로고    scopus 로고
    • Analysis of the p53/bax pathway in colorectal cancer: Low bax is a negative prognostic factor in patients with resected liver metastases
    • Sturm I, Kohne CH, Wolff G, Petrowsky H, Hillebrand T, Hauptmann S, Lorenz M, Dörken B and Daniel PT (1999) Analysis of the p53/bax pathway in colorectal cancer: low bax is a negative prognostic factor in patients with resected liver metastases. J. Clin. Oncol. 17: 1364-1374
    • (1999) J. Clin. Oncol. , vol.17 , pp. 1364-1374
    • Sturm, I.1    Kohne, C.H.2    Wolff, G.3    Petrowsky, H.4    Hillebrand, T.5    Hauptmann, S.6    Lorenz, M.7    Dörken, B.8    Daniel, P.T.9
  • 18
    • 0036097786 scopus 로고    scopus 로고
    • Keeping killers on a tight leash: Transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins
    • Puthalakath H and Strasser A (2002) Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ. 9: 505-512
    • (2002) Cell Death Differ. , vol.9 , pp. 505-512
    • Puthalakath, H.1    Strasser, A.2
  • 20
    • 0035265686 scopus 로고    scopus 로고
    • Puma, a novel proapoptotic gene, is induced by p53
    • Nakano K and Vousden KH (2001) Puma, a novel proapoptotic gene, is induced by p53. Mol. Cell 7: 683-694
    • (2001) Mol. Cell , vol.7 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 21
    • 0035821652 scopus 로고    scopus 로고
    • DNA microarray analysis of genes involved in p53 mediated apoptosis: Activation of APAF-1
    • Kannan K, Kaminski N, Rechavi G, Jakob-Hirsch J, Amariglio N and Givol D (2001) DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of APAF-1. Oncogene 20: 3449-3455
    • (2001) Oncogene , vol.20 , pp. 3449-3455
    • Kannan, K.1    Kaminski, N.2    Rechavi, G.3    Jakob-Hirsch, J.4    Amariglio, N.5    Givol, D.6
  • 23
    • 0027451668 scopus 로고
    • P53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe SW, Ruley HE, Jacks T and Housman DE (1993) P53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74: 957-967
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 24
    • 0030029580 scopus 로고    scopus 로고
    • Novel ex vivo analysis of nonclassical, pleiotropic drug resistance and collateral sensitivity induced by therapy provides a rationale for treatment strategies in chronic lymphocytic leukemia
    • Bosanquet AG and Bell PB (1996) Novel ex vivo analysis of nonclassical, pleiotropic drug resistance and collateral sensitivity induced by therapy provides a rationale for treatment strategies in chronic lymphocytic leukemia. Blood 87: 1962-1971
    • (1996) Blood , vol.87 , pp. 1962-1971
    • Bosanquet, A.G.1    Bell, P.B.2
  • 25
    • 0034091153 scopus 로고    scopus 로고
    • Ex vivo assessment of drug response by differential staining cytotoxicity (disc) assay suggests a biological basis for equality of chemotherapy irrespective of age for patients with chronic lymphocytic leukaemia
    • Bosanquet AG and Bosanquet MI (2000) Ex vivo assessment of drug response by differential staining cytotoxicity (disc) assay suggests a biological basis for equality of chemotherapy irrespective of age for patients with chronic lymphocytic leukaemia. Leukemia 14: 712-715
    • (2000) Leukemia , vol.14 , pp. 712-715
    • Bosanquet, A.G.1    Bosanquet, M.I.2
  • 28
    • 0027436745 scopus 로고
    • P53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of mdr1/mdr3 gene expression
    • el Rouby S, Thomas A, Costin D, Rosenberg CR, Potmesil M, Silber R and Newcomb EW (1993) P53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of mdr1/mdr3 gene expression. Blood 82: 3452-3459
    • (1993) Blood , vol.82 , pp. 3452-3459
    • el Rouby, S.1    Thomas, A.2    Costin, D.3    Rosenberg, C.R.4    Potmesil, M.5    Silber, R.6    Newcomb, E.W.7
  • 29
    • 0033869494 scopus 로고    scopus 로고
    • Role of poly(ADP-ribosyl)ation in the killing of chronic lymphocytic leukemia cells by purine analogues
    • Pettitt AR, Sherrington PD and Cawley JC (2000) Role of poly(ADP-ribosyl)ation in the killing of chronic lymphocytic leukemia cells by purine analogues. Cancer Res. 60: 4187-4193
    • (2000) Cancer Res. , vol.60 , pp. 4187-4193
    • Pettitt, A.R.1    Sherrington, P.D.2    Cawley, J.C.3
  • 31
  • 33
    • 0035156737 scopus 로고    scopus 로고
    • Insights into cancer therapeutic design based on p53 and trail receptor signaling
    • El-Deiry WS (2001) Insights into cancer therapeutic design based on p53 and trail receptor signaling. Cell Death Differ. 8: 1066-1075
    • (2001) Cell Death Differ. , vol.8 , pp. 1066-1075
    • El-Deiry, W.S.1
  • 34
    • 0035156707 scopus 로고    scopus 로고
    • P53-dependent pathways of apoptosis
    • Benchimol S (2001) P53-dependent pathways of apoptosis. Cell Death Differ. 8: 1049-1051
    • (2001) Cell Death Differ. , vol.8 , pp. 1049-1051
    • Benchimol, S.1
  • 35
    • 0035154327 scopus 로고    scopus 로고
    • DNA damage and apoptosis
    • Wang JY (2001) DNA damage and apoptosis. Cell Death Differ. 8: 1047-1048
    • (2001) Cell Death Differ. , vol.8 , pp. 1047-1048
    • Wang, J.Y.1
  • 36
    • 0033891414 scopus 로고    scopus 로고
    • Radiation-induced apoptosis in the adult central nervous system is p53-dependent
    • Chow BM, Li YQ and Wong CS (2000) Radiation-induced apoptosis in the adult central nervous system is p53-dependent. Cell Death Differ. 7: 712-720
    • (2000) Cell Death Differ. , vol.7 , pp. 712-720
    • Chow, B.M.1    Li, Y.Q.2    Wong, C.S.3
  • 38
    • 0032563952 scopus 로고    scopus 로고
    • Secondary acute leukemia in chronic lymphocytic leukemia
    • Grunwald HW and Rosner F (1998) Secondary acute leukemia in chronic lymphocytic leukemia. N. Engl. J. Med. 339: 924
    • (1998) N. Engl. J. Med. , vol.339 , pp. 924
    • Grunwald, H.W.1    Rosner, F.2
  • 39
    • 0017606940 scopus 로고
    • Chronic lymphocytic leukemia terminating in acute leukemia
    • Zarrabi MH, Grunwald HW and Rosner F (1977) Chronic lymphocytic leukemia terminating in acute leukemia. Arch. Intern. Med. 137: 1054-1059
    • (1977) Arch. Intern. Med. , vol.137 , pp. 1054-1059
    • Zarrabi, M.H.1    Grunwald, H.W.2    Rosner, F.3
  • 40
    • 0026696771 scopus 로고
    • P53 mutations in C57BI/6J murine thymic lymphomas induced by gamma-irradiation and n-methylnitrosourea
    • Brathwaite O, Bayona W and Newcomb EW (1992) P53 mutations in C57BI/6J murine thymic lymphomas induced by gamma-irradiation and n-methylnitrosourea. Cancer Res. 52: 3791-3795
    • (1992) Cancer Res. , vol.52 , pp. 3791-3795
    • Brathwaite, O.1    Bayona, W.2    Newcomb, E.W.3
  • 41
    • 0035132847 scopus 로고    scopus 로고
    • Evidence for the development of p53 mutations after cytotoxic therapy in a neuroblastoma cell line
    • Tweddle DA, Malcolm AJ, Bown N, Pearson AD and Lunec J (2001) Evidence for the development of p53 mutations after cytotoxic therapy in a neuroblastoma cell line. Cancer Res. 61: 8-13
    • (2001) Cancer Res. , vol.61 , pp. 8-13
    • Tweddle, D.A.1    Malcolm, A.J.2    Bown, N.3    Pearson, A.D.4    Lunec, J.5
  • 43
    • 0028091651 scopus 로고
    • Clinical significance of p53 mutations in relapsed T-cell acute lymphoblastic leukemia
    • Diccianni MB, Yu J, Hsiao M, Mukherjee S, Shao LE and Yu AL (1994) Clinical significance of p53 mutations in relapsed T-cell acute lymphoblastic leukemia. Blood 84: 3105-3112
    • (1994) Blood , vol.84 , pp. 3105-3112
    • Diccianni, M.B.1    Yu, J.2    Hsiao, M.3    Mukherjee, S.4    Shao, L.E.5    Yu, A.L.6
  • 44
    • 0030664518 scopus 로고    scopus 로고
    • Exon 5 mutations in the p53 gene in relapsed childhood acute lymphoblastic leukemia
    • Blau O, Avigad S, Stark B, Kodman Y, Luria D, Cohen IJ and Zaizov R (1997) Exon 5 mutations in the p53 gene in relapsed childhood acute lymphoblastic leukemia. Leuk. Res. 21: 721-729
    • (1997) Leuk. Res. , vol.21 , pp. 721-729
    • Blau, O.1    Avigad, S.2    Stark, B.3    Kodman, Y.4    Luria, D.5    Cohen, I.J.6    Zaizov, R.7
  • 45
    • 0028008553 scopus 로고
    • Directional selection associated with clonal expansion of p53 mutant cells during neoplastic development of carcinogen-treated rat embryo lung epithelial cells
    • Le Rhun Y, Duthu A, Ehrhart JC, Michiels F, May E and May P (1994) Directional selection associated with clonal expansion of p53 mutant cells during neoplastic development of carcinogen-treated rat embryo lung epithelial cells. Oncogene 9: 263-271
    • (1994) Oncogene , vol.9 , pp. 263-271
    • Le Rhun, Y.1    Duthu, A.2    Ehrhart, J.C.3    Michiels, F.4    May, E.5    May, P.6
  • 46
    • 0032844150 scopus 로고    scopus 로고
    • The effect of p53 dysfunction on purine analogue cytotoxicity in chronic lymphocytic leukaemia
    • Pettitt AR, Sherrington PD and Cawley JC (1999) The effect of p53 dysfunction on purine analogue cytotoxicity in chronic lymphocytic leukaemia. Br. J. Haematol. 106: 1049-1051
    • (1999) Br. J. Haematol. , vol.106 , pp. 1049-1051
    • Pettitt, A.R.1    Sherrington, P.D.2    Cawley, J.C.3
  • 47
    • 0029978058 scopus 로고    scopus 로고
    • Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: Relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance
    • Thomas A, El RS, Reed JC, Krajewski S, Silber R, Potmesil M and Newcomb EW (1996) Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance. Oncogene 12: 1055-1062
    • (1996) Oncogene , vol.12 , pp. 1055-1062
    • Thomas, A.1    El, R.S.2    Reed, J.C.3    Krajewski, S.4    Silber, R.5    Potmesil, M.6    Newcomb, E.W.7
  • 48
    • 0031450247 scopus 로고    scopus 로고
    • Bcl-2 protein expression and p53 gene mutation in chronic lymphocytic leukemia: Correlation with in vitro sensitivity to chlorambucil and purine analogs
    • Morabito F, Filangeri M, Callea I, Sculli G, Callea V, Fracchiolla NS, Neri A and Brugiatelli M (1997) Bcl-2 protein expression and p53 gene mutation in chronic lymphocytic leukemia: correlation with in vitro sensitivity to chlorambucil and purine analogs. Haematologica 82: 16-20
    • (1997) Haematologica , vol.82 , pp. 16-20
    • Morabito, F.1    Filangeri, M.2    Callea, I.3    Sculli, G.4    Callea, V.5    Fracchiolla, N.S.6    Neri, A.7    Brugiatelli, M.8
  • 49
    • 0034669944 scopus 로고    scopus 로고
    • Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria
    • Genini D, Adachi S, Chao Q, Rose DW, Carrera CJ, Cottam HB, Carson DA and Leoni LM (2000) Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. Blood 96: 3537-3543
    • (2000) Blood , vol.96 , pp. 3537-3543
    • Genini, D.1    Adachi, S.2    Chao, Q.3    Rose, D.W.4    Carrera, C.J.5    Cottam, H.B.6    Carson, D.A.7    Leoni, L.M.8
  • 52
    • 0029328641 scopus 로고
    • Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway
    • Woods CM, Zhu J, McQueney PA, Bollag D and Lazarides E (1995) Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway. Mol. Med. 1: 506-526
    • (1995) Mol. Med. , vol.1 , pp. 506-526
    • Woods, C.M.1    Zhu, J.2    McQueney, P.A.3    Bollag, D.4    Lazarides, E.5
  • 53
    • 0029981025 scopus 로고    scopus 로고
    • National cancer institute-sponsored working group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment
    • Cheson BD, Bennett A Grever M, Kay N, Keating MJ, O'Brien S and Rai KR (1996) National cancer institute-sponsored working group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 87: 4990-4997
    • (1996) Blood , vol.87 , pp. 4990-4997
    • Cheson, B.D.1    Bennett, A.2    Grever, M.3    Kay, N.4    Keating, M.J.5    O'Brien, S.6    Rai, K.R.7
  • 54
    • 0029963932 scopus 로고    scopus 로고
    • Enhanced ex vivo drug sensitivity testing of chronic lymphocytic leukaemia using refined disc assay methodology
    • Bosanquet AG and Bell PB (1996) Enhanced ex vivo drug sensitivity testing of chronic lymphocytic leukaemia using refined disc assay methodology. Leuk. Res. 20: 143-153
    • (1996) Leuk. Res. , vol.20 , pp. 143-153
    • Bosanquet, A.G.1    Bell, P.B.2


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