Impaired BAX protein expression in breast cancer: Mutational analysis of the BAX and the p53 gene

International Journal of Cancer

Volumn 87, Issue 4, 2000, Pages 517-521

  Sturm, Isrid ^a   Papadopoulos, Sarantos ^a   Hillebrand, Timo ^b   Benter, Thomas ^a   Lück, Hans Joachim ^c   Wolff, Gerhard ^d   Dörken, Bernd ^a,e   Daniel, Peter T ^a,e  

^a HUMBOLDT UNIVERSITY   (Germany)

^b Invitek GmbH   (Germany)

^c MH Hannover ^*  (Germany)

^d Theragen AG   (Germany)

^e MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BAX; PROTEIN P53;

ALLELE; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

BASE SEQUENCE; BCL-2-ASSOCIATED X PROTEIN; BINDING SITES; BREAST NEOPLASMS; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HUMANS; IMMUNOHISTOCHEMISTRY; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; TRANS-ACTIVATION (GENETICS);

EID: 0033883376     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20000815)87:4<517::AID-IJC9>3.0.CO;2-B     Document Type: Article

References (26)

1. Expression of the bcl-2 gene family in normal and malignant breast tissue: Low bax-alpha expression in tumor cells correlates with resistance towards apoptosis
2. Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice
3. BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability
4. The BAX gene maps to the glioma candidate region at 19q13.3, but is not altered in human gliomas
5. HMLH1 and hMSH2 expression and BAX frameshift mutations in ovarian cancer cell lines and tumors
6. Bax, but not bcl-2, influences the prognosis of human pancreatic cancer
7. Prognostic significance of BAX protein expression in diffuse aggressive Non-Hodgkin's lymphoma
8. Bcl-2/bax mRNA expression ratio as a prognostic factor in low-grade urinary bladder cancer
9. Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma
10. p53 status and the efficacy of cancer therapy in vivo
11. Bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis
12. Hematopoietic malignancies demonstrate loss-of-function mutations of BAX
13. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
14. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction
15. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
16. BCL-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapy
17. Boo, a novel negative regulator of cell death, interacts with Apaf-1
18. Analysis of the p53/BAX pathway in colorectal cancer: Low BAX is a negative prognostic factor in patients with resected liver metastases
19. BAX protein expression and clinical outcome in epithelial ovarian cancer
20. Induction of the death-promoting gene bax-alpha sensitizes cultured breast-cancer cells to drug-induced apoptosis
21. Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7
22. Proapoptotic gene BAX is frequently mutated in hereditary nonpolyposis colorectal cancers but not in adenomas
23. Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer
24. Expression of Bcl-2, but not Bax, correlates with estrogen receptor status and tumor proliferation in invasive breast carcinoma
25. Bax suppresses tumorigenesis and stimulates apoptosis in vivo
26. Tamoxifen-induced apoptosis in breast cancer cells relates to down- regulation of bcl-2, but not bax and bcl-X(L), without alteration of p53 protein levels