Dissecting the pathways to death

Leukemia

Volumn 14, Issue 12, 2000, Pages 2035-2044

  Daniel, P T ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Apoptosis; Bcl 2; Death receptors; Endoplasmic reticulum; Mitochondria; Programmed cell death

Indexed keywords

CASPASE; CASPASE 8; CASPASE 9; CYCLIN D1; CYTOCHROME C; FAS ANTIGEN; MITOCHONDRIAL DNA; MYC PROTEIN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MDM2; PROTEIN P16; PROTEIN P21; PROTEIN P53; SOMATOMEDIN BINDING PROTEIN 3; TRANSCRIPTION FACTOR E2F; TUMOR NECROSIS FACTOR; VIRUS VECTOR;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; CANCER CELL; CELL DEATH; CELL SURVIVAL; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG SENSITIZATION; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; GENE TRANSFER; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; MEMBRANE CHANNEL; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FAMILY; RADIOSENSITIZATION; REVIEW; SIGNAL TRANSDUCTION; STRESS; STROKE;

EID: 0034520470     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401940     Document Type: Review

References (50)

1. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
2. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
3. Bid, a Bcl-2 interacting protein, mediates cytochrome c release in response to activation of cell surface death receptors
4. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis
5. CD95(APO-1/Fas)-mediated apoptosis: Live and let die
6. CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10
7. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases
8. Cell death beyond apoptosis
9. Bcl-2 proteins: Regulators of apoptosis or of mitochondrial homeostasis?
10. Mitochondrial control of death
11. Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity
12. Expression of the bcl-2 gene family in normal and malignant breast tissue: Low bax-alpha expression in tumor cells correlates with resistance towards apoptosis
13. Relapse in childhood acute lymphoblastic leukemia is associated with decrease of Bax/Bcl-2- ratio and loss of spontaneous caspase-3 processing in vivo
14. Analysis of the p53/BAX pathway in colorectal cancer: Low BAX is a negative prognostic factor in patients with resected liver metastases
15. Differential BAX expression in breast cancer is independent of BAX mutation
16. Protein, Structure X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
17. Apoptosis inducing factor (AIF): A phylogenetically old, caspase-independent effector of cell death
18. Intracellular signaling from the endoplasmic reticulum to the nucleus
19. Signal transduction from the endoplasmic reticulum to the cell nucleus
20. Calpain activation in apoptosis
21. P53 website and analysis of p53 gene mutations in cancer: Forging a link between epidemiology and carcinogenesis
22. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
23. Genomic instability in Gadd45a-deficient mice
24. The ARF/p53 pathway
25. Differences between CD95 type I and II cells detected with the CD95 ligand
26. Inhibition of death receptor signals by cellular FLIP
27. Regulation of germinal center B cell differentiation: Role of the human APO-1/fas (CD95) antigen
28. Activation induces sensitivity towards APO-1 (CD95)-mediated apoptosis in human B cells
29. Activation and activation-induced death of human tonsillar B cells and Burkitt lymphoma cells: Lack of CD95 (Fas/APO-1) ligand expression and function
30. Caspase structure, proteolytic substrates, and function during apoptotic cell death
31. Divinations and surprises: Genetic analysis of caspase function in mice
32. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer
33. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
34. Germinal center-derived signals act with Bcl-2 to decrease apoptosis and increase clonogenicity of drug-treated human B lymphoma cells
35. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
36. Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of Fas or FADD/MORT1 signaling. Implications for cancer therapy
37. Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells
38. Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction
39. Immediate effects of reversible HTLV-1 tax function: T-cell activation and apoptosis
40. The repression of apoptosis by activated abl oncogenes in chronic myelogenous leukemia
41. Bcr-abl maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death
42. In acute promyelocytic leukemia NB4 cells, the synthetic retinoid CD437 induces contemporaneously apoptosis, a caspase-3-mediated degradation of PML/RARalpha protein and the PML retargeting on PML-nuclear bodies
43. The acute promyelocytic leukemia-specific PML-RAR fusion protein inhibits differentiation and promotes survival of myeloid precursor cells
44. PML is essential for multiple apoptotic pathways
45. The apoptosis inhibitor gene AP12 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas
46. mE10, a novel caspase recruitment domain-containing proapoptotic molecule
47. Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)
48. Induction of resistance to the Abelson inhibitor ST1571 in leukemic cells through gene amplification
49. Combined arsenic and retinoic acid treatment enhances differentiation and apoptosis in arsenic-resistant NB4 cells
50. Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia