Abrogation of G2 checkpoint specifically sensitize p53 defective cells to cancer chemotherapeutic agents

Anticancer Research

Volumn 21, Issue 1 A, 2001, Pages 23-28

  Luo, Y ^a   Rockow Magnone, S K ^a   Joseph, M K ^a   Bradner, J ^a   Butler, C C ^a   Tahir, S K ^a   Han, E K H ^a   Ng, S C ^a   Severin, J M ^a   Gubbins, E J ^a   Reilly, R M ^a   Rueter, A ^a   Simmer, R L ^a   Holzman, T F ^a   Giranda, V L ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Chemotherapy sensitization; Chk1; G2 abrogation; Staurosporine; UCN01

Indexed keywords

7 HYDROXYSTAUROSPORINE; ANTINEOPLASTIC AGENT; CELL CYCLE PROTEIN; DOXORUBICIN; PROTEIN P53; STAUROSPORINE;

ARTICLE; CANCER CHEMOTHERAPY; CELL CYCLE G2 PHASE; CELL DEATH; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; GENE INACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ALKALOIDS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TRANSFORMED; DNA DAMAGE; DOXORUBICIN; ENZYME INHIBITORS; G2 PHASE; HUMANS; NEOPLASMS; PROTEIN KINASES; STAUROSPORINE; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035062416     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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