3D QSAR analyses-guided rational design of novel ligands for the (α4)2(β2)3 nicotinic acetylcholine receptor

Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2003, Pages 2031-2048

  Gohlke, Holger ^a,c   Schwarz, Simone ^a   Gündisch, Daniela ^b   Tilotta, Maria Cristina ^b   Weber, Alexander ^a   Wegge, Thomas ^a   Seitz, Gunther ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2' CHLOROPYRIMIDIN 5' YL) 8 AZABICYCLO[3.2.1]OCT 2 ENE; 2 (3' CHLOROPYRAZIN 2' YL) 8 AZABICYCLO[3.2.1]OCT 2 ENE; 2 (3' PYRIDINYL) 8 AZABICYCLO[3.2.1]OCT 2 ENE; 3 (2' CHLOROPYRIMIDIN 5' YL) 8 AZABICYCLO[3.2.1]OCT 2 ENE; 3 (3' CHLOROPYRAZIN 2' YL) 8 AZABICYCLO[3.2.1]OCT 2 ENE; 3 (3' PYRIDINYL) 8 AZABICYCLO[3.2.1]OCT 2 ENE MALEATE; 8 AZABICYCLO[3.2.1]OCT 2 ENE CARBOXYLIC ACID DIMETHYLAMIDE; 8 AZABICYCLO[3.2.1]OCT 2 ENE THIOCARBOXYLIC ACID DIMETHYLAMIDE; 8 METHYL 8 AZABICYCLO[3.2.1]OCT 2 ENE 2 CARBOXYLIC ACID DIMETHYLAMIDE; 8 METHYL 8 AZABICYCLO[3.2.1]OCT 2 ENE 2 THIOCARBOXYLIC ACID DIMETHYLAMIDE; ANATOXIN A; CYTISINE; EPIBATIDINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRICITY; HYDROGEN BOND; HYDROPHOBICITY; PHYSICAL CHEMISTRY; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR AFFINITY; STATISTICAL MODEL; STEREOSPECIFICITY;

ALKALOIDS; ANIMALS; AZOCINES; BACTERIAL TOXINS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING, COMPETITIVE; DRUG DESIGN; LIGANDS; MARINE TOXINS; MICROCYSTINS; MODELS, MOLECULAR; PROSENCEPHALON; PROTEIN SUBUNITS; PYRIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUINOLIZINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; STEREOISOMERISM;

EID: 0037573351     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020859m     Document Type: Article

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