Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (±)-UB-165

Journal of Medicinal Chemistry

Volumn 45, Issue 15, 2002, Pages 3235-3245

  Sharples, Christopher G V ^a   Karig, Gunter ^b   Simpson, Graham L ^b   Spencer, James A ^b   Wright, Emma ^b   Millar, Neil S ^c   Wonnacott, Susan ^a   Gallagher, Timothy ^a  

^a University of Bath   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 PYRAZINYL) 9 AZABICYCLO[4.2.1]NON 2 ENE; 2 (2 PYRIDINYL) 9 AZABICYCLO[4.2.1]NON 2 ENE; 2 (3 PYRIDAZINYL) 9 AZABICYCLO[4.2.1]NON 2 ENE; 2 (3 PYRIDINYL) 9 AZABICYCLO[4.2.1]NON 2 ENE; 2 (4 PYRIDINYL) 9 AZABICYCLO[4.2.1]NON 2 ENE; 2 (5 PYRIMIDINYL) 9 AZABICYCLO[4.2.1]NON 2 ENE; 9 AZABICYCLO[4.2.1]NONENE DERIVATIVE; ANATOXIN A; EPIBATIDINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; PYRAZINE DERIVATIVE; PYRIDAZINE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; RECEPTOR SUBTYPE; UB 165; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ISOMER; MOUSE; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; BRAIN; BRIDGED COMPOUNDS; CELL LINE; LIGANDS; MOLECULAR CONFORMATION; MONTE CARLO METHOD; NEURONS; NICOTINIC AGONISTS; PYRAZINES; PYRIDAZINES; PYRIDINES; PYRIMIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, NICOTINIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037130235     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020814l     Document Type: Article

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