The identification of novel structural compound classes exhibiting high affinity for neuronal nicotinic acetylcholine receptors and analgesic efficacy in preclinical models of pain

European Journal of Pharmacology

Volumn 393, Issue 1-3, 2000, Pages 171-177

  Meyer, Michael D ^a   Decker, Michael W ^a   Rueter, Lynne E ^a   Anderson, David J ^a   Dart, Michael J ^a   Kim, Ki H ^a   Sullivan, James P ^a   Williams, Michael ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

A 85380; ABT 594; Analgesia; Antinociception; Epibatidine; Molecular model; Nicotinic acetylcholine receptor

Indexed keywords

2 AZABICYCLO[2.2.1]CYCLOHEPTANE DERIVATIVE; 5 (2 AZETIDINYLMETHOXY) 2 CHLOROPYRIDINE; A 84543; ANALGESIC AGENT; EPIBATIDINE; FURO[2,3 B]PYRIDINE DERIVATIVE; FURO[3,2 C]PYRIDINE DERIVATIVE; NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; CONFERENCE PAPER; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG TARGETING; LOCUS CERULEUS; NONHUMAN; PAIN; PRIORITY JOURNAL; RAPHE MAGNUS NUCLEUS; RAT; STRUCTURE ACTIVITY RELATION;

ANALGESICS; ANIMALS; AZETIDINES; BICYCLO COMPOUNDS, HETEROCYCLIC; HUMANS; MODELS, MOLECULAR; NEURONS; NICOTINE; NICOTINIC AGONISTS; PAIN; PYRIDINES; RATS; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034732362     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00041-8     Document Type: Article

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