메뉴 건너뛰기




Volumn 170, Issue 4, 2003, Pages 1995-2003

NF-κB1 is required for optimal CD4+ Th1 cell development and resistance to Leishmania major

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR;

EID: 0037442135     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.4.1995     Document Type: Article
Times cited : (44)

References (80)
  • 1
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights
    • Baldwin, A. S., Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 649
    • Baldwin A.S., Jr.1
  • 2
    • 0031897632 scopus 로고    scopus 로고
    • NF-κB and Re1 proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh, S., M. J. May, and E. B. Kopp. 1998. NF-κB and Re1 proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16:225.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 225
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 3
    • 0033595893 scopus 로고    scopus 로고
    • How NF-κB is activated: The role of the IKB kinase (IKK) complex
    • Karin, M. 1999. How NF-κB is activated: the role of the IKB kinase (IKK) complex, Oncogene 18:6867.
    • (1999) Oncogene , vol.18 , pp. 6867
    • Karin, M.1
  • 4
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-κB activity
    • Karin, M., and Y. Ben-Neriah. 2000. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu. Rev. Immunol. 18:621.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 621
    • Karin, M.1    Ben-Neriah, Y.2
  • 5
    • 0033996762 scopus 로고    scopus 로고
    • The IκB kinase (IKK) and NF-κB: Key elements of proinflammatory signalling
    • Karin, M., and M. Delhase. 2000. The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling. Semin. Immunol. 12:85.
    • (2000) Semin. Immunol. , vol.12 , pp. 85
    • Karin, M.1    Delhase, M.2
  • 6
    • 0032771055 scopus 로고    scopus 로고
    • Regulation of inducible gene expression by the transcription factor NF-κB
    • Ghosh, S. 1999. Regulation of inducible gene expression by the transcription factor NF-κB. Immunol. Res. 19:183.
    • (1999) Immunol. Res. , vol.19 , pp. 183
    • Ghosh, S.1
  • 7
    • 0035983295 scopus 로고    scopus 로고
    • NF-κB family of transcription factors: Central regulators of innate and adaptive immune functions
    • Caamaño, J., and C. A. Hunter, 2002, NF-κB family of transcription factors: central regulators of innate and adaptive immune functions. Clin. Microbiol. Rev, 15:414.
    • (2002) Clin. Microbiol. Rev, , vol.15 , pp. 414
    • Caamaño, J.1    Hunter, C.A.2
  • 8
    • 0036081269 scopus 로고    scopus 로고
    • Host-pathogen interactions: Subversion and utilization of the NF-κB pathway during infection
    • Tato, C. M., and C. A. Hunter, 2002. Host-pathogen interactions: subversion and utilization of the NF-κB pathway during infection. Infect. Immun. 70:3311.
    • (2002) Infect. Immun. , vol.70 , pp. 3311
    • Tato, C.M.1    Hunter, C.A.2
  • 9
    • 0031159205 scopus 로고    scopus 로고
    • Multifocal defects in immune responses in Re1B-deficient mice
    • Weih, F., G. Warr, H. Yang, and R. Bravo. 1997. Multifocal defects in immune responses in Re1B-deficient mice. J. Immunol. 158:5211.
    • (1997) J. Immunol. , vol.158 , pp. 5211
    • Weih, F.1    Warr, G.2    Yang, H.3    Bravo, R.4
  • 10
    • 0032864097 scopus 로고    scopus 로고
    • The NF-κB family member Re1B is required for innate and adaptive immunity to Toxoplasma gondii
    • Caamaño, J., J. Alexander, L. Craig, R. Bravo, and C. A. Hunter. 1999. The NF-κB family member Re1B is required for innate and adaptive immunity to Toxoplasma gondii. J. Immunol. 163:4453.
    • (1999) J. Immunol. , vol.163 , pp. 4453
    • Caamaño, J.1    Alexander, J.2    Craig, L.3    Bravo, R.4    Hunter, C.A.5
  • 11
    • 0032881384 scopus 로고    scopus 로고
    • Mice lacking the transcription factor subunit Re1 can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response
    • Harling-McNabb, L., G. Deliyannis, D. C. Jackson, S. Gerondakis, G. Grigoriadis, and L. E. Brown. 1999. Mice lacking the transcription factor subunit Re1 can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response. Int. Immunol. 11:1431.
    • (1999) Int. Immunol. , vol.11 , pp. 1431
    • Harling-McNabb, L.1    Deliyannis, G.2    Jackson, D.C.3    Gerondakis, S.4    Grigoriadis, G.5    Brown, L.E.6
  • 13
    • 0036569015 scopus 로고    scopus 로고
    • NF-κB2 is required for optimal CD40-induced IL-12 production but dispensable for Th1 cell differentiation
    • Speirs, K., J. Caamaño, M. H. Goldschmidt, C. A. Hunter, and P. Scott. 2002. NF-κB2 is required for optimal CD40-induced IL-12 production but dispensable for Th1 cell differentiation. J. Immunol. 168:4406.
    • (2002) J. Immunol. , vol.168 , pp. 4406
    • Speirs, K.1    Caamaño, J.2    Goldschmidt, M.H.3    Hunter, C.A.4    Scott, P.5
  • 15
    • 0028933795 scopus 로고
    • The regulation of immunity to Leishmania major
    • Reiner, S. L., and R. M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 151
    • Reiner, S.L.1    Locksley, R.M.2
  • 17
    • 0031918448 scopus 로고    scopus 로고
    • Differentiation, regulation, and death of T helper cell subsets during infection with Leishmania major
    • Scott, P. 1998. Differentiation, regulation, and death of T helper cell subsets during infection with Leishmania major. Immunol. Res. 17:229.
    • (1998) Immunol. Res. , vol.17 , pp. 229
    • Scott, P.1
  • 18
    • 0030481581 scopus 로고    scopus 로고
    • The Re1 subunit of NF-κB-like transcription factors is a positive and negative regulator of macrophage gene expression: Distinct roles for Re1 in different macrophage populations
    • Grigoriadis, G., Y. Zhan, R. J. Grumont, D, Metcalf, E. Handman, C. Cheers, and S. Gerondakis. 1996. The Re1 subunit of NF-κB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Re1 in different macrophage populations. EMBO J. 15:7099.
    • (1996) EMBO J. , vol.15 , pp. 7099
    • Grigoriadis, G.1    Zhan, Y.2    Grumont, R.J.3    Metcalf, D.4    Handman, E.5    Cheers, C.6    Gerondakis, S.7
  • 19
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng, W., and R. A, Flavell. 1997. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89:587.
    • (1997) Cell , vol.89 , pp. 587
    • Zheng, W.1    Flavell, R.A.2
  • 21
    • 0035222187 scopus 로고    scopus 로고
    • A critical role for NF-κB in GATA-3 expression and Th2 differentiation in allergic airway inflammation
    • Das, J., C. H. Chen, L. Yang, L. Cohn, P. Ray, and A. Ray. 2001. A critical role for NF-κB in GATA-3 expression and Th2 differentiation in allergic airway inflammation. Nat. Immun. 2:45.
    • (2001) Nat. Immun. , vol.2 , pp. 45
    • Das, J.1    Chen, C.H.2    Yang, L.3    Cohn, L.4    Ray, P.5    Ray, A.6
  • 22
    • 0032476742 scopus 로고    scopus 로고
    • Essential role of NF-κB in the induction of eosinophilia in allergic airway inflammation
    • Yang, L., L. Cohn, D. H. Zhang, R. Homer, A. Ray, and P. Ray. 1998. Essential role of NF-κB in the induction of eosinophilia in allergic airway inflammation. J. Exp. Med. 188:1739.
    • (1998) J. Exp. Med. , vol.188 , pp. 1739
    • Yang, L.1    Cohn, L.2    Zhang, D.H.3    Homer, R.4    Ray, A.5    Ray, P.6
  • 23
    • 0035375077 scopus 로고    scopus 로고
    • Specificity of sn50 for NF-κB?
    • Boothby, M. 2001. Specificity of sn50 for NF-κB? Nat. Immun. 2:471.
    • (2001) Nat. Immun. , vol.2 , pp. 471
    • Boothby, M.1
  • 24
  • 26
    • 0033198141 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis in NF-κB-deficient mice: Roles of NF-κB in the activation and differentiation of autoreactive T cells
    • Hilliard, B., E. B. Samoilova, T. S. Liu, A. Rostami, and Y. Chen. 1999. Experimental autoimmune encephalomyelitis in NF-κB-deficient mice: roles of NF-κB in the activation and differentiation of autoreactive T cells. J. Immunol. 163:29-37.
    • (1999) J. Immunol. , vol.163 , pp. 29-37
    • Hilliard, B.1    Samoilova, E.B.2    Liu, T.S.3    Rostami, A.4    Chen, Y.5
  • 27
    • 0028804551 scopus 로고
    • Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
    • Sha, W. C., H. C. Liou, E. I. Tuomanen, and D. Baltimore. 1995. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80:321.
    • (1995) Cell , vol.80 , pp. 321
    • Sha, W.C.1    Liou, H.C.2    Tuomanen, E.I.3    Baltimore, D.4
  • 28
    • 0023265277 scopus 로고
    • Vaccination against cutaneous leishmaniasis in a murine model. II. Immunologic properties of protective and nonprotective subfractions of soluble promastigote extract
    • Scott, P., E. Pearce, P. Natovitz, and A. Sher. 1987. Vaccination against cutaneous leishmaniasis in a murine model. II. Immunologic properties of protective and nonprotective subfractions of soluble promastigote extract. J. Immunol. 139: 3118.
    • (1987) J. Immunol. , vol.139 , pp. 3118
    • Scott, P.1    Pearce, E.2    Natovitz, P.3    Sher, A.4
  • 29
    • 0037083252 scopus 로고    scopus 로고
    • Suppression of NF-κB activation by infection with Toxoplasma gondii
    • Shapira, S., K. Speirs, A. Gerstein. J. Caamaño, and C. A. Hunter. 2002. Suppression of NF-κB activation by infection with Toxoplasma gondii. J. Infect. Dis. 185(Suppl. 1):S66.
    • (2002) J. Infect. Dis. , vol.185 , Issue.SUPPL. 1
    • Shapira, S.1    Speirs, K.2    Gerstein, A.3    Caamaño, J.4    Hunter, C.A.5
  • 30
    • 0020078038 scopus 로고
    • Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy
    • Tushinski, R. J., I. T. Oliver, L. J. Guilbert, P. W. Tynan, J. R. Warner, and E. R. Stanley. 1982. Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy. Cell 28:71.
    • (1982) Cell , vol.28 , pp. 71
    • Tushinski, R.J.1    Oliver, I.T.2    Guilbert, L.J.3    Tynan, P.W.4    Warner, J.R.5    Stanley, E.R.6
  • 31
    • 0021909157 scopus 로고
    • Bone marrow-derived macrophages: Development and regulation of differentiation markers by colony-stimulating factor and interferons
    • Warren, M. K., and S. N. Vogel. 1985. Bone marrow-derived macrophages: development and regulation of differentiation markers by colony-stimulating factor and interferons. J. Immunol. 134:982.
    • (1985) J. Immunol. , vol.134 , pp. 982
    • Warren, M.K.1    Vogel, S.N.2
  • 32
    • 0033012030 scopus 로고    scopus 로고
    • An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    • Lutz, M. B., N. Kukutsch, A. L. Ogilvie, S. Rossner, F. Koch, N. Romani, and G. Schuler. 1999. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 223: 77.
    • (1999) J. Immunol. Methods , vol.223 , pp. 77
    • Lutz, M.B.1    Kukutsch, N.2    Ogilvie, A.L.3    Rossner, S.4    Koch, F.5    Romani, N.6    Schuler, G.7
  • 36
    • 0019816758 scopus 로고
    • Intracellular replication and lymphokine-induced destruction of Leishmania tropica in C3H/ HeN mouse macrophages
    • Nacy, C. A., M. S. Meltzer, E. J. Leonard, and D. J. Wyler. 1981. Intracellular replication and lymphokine-induced destruction of Leishmania tropica in C3H/ HeN mouse macrophages. J. Immunol. 127:2381.
    • (1981) J. Immunol. , vol.127 , pp. 2381
    • Nacy, C.A.1    Meltzer, M.S.2    Leonard, E.J.3    Wyler, D.J.4
  • 37
    • 0028262128 scopus 로고
    • Determination of lymphocyte division by flow cytometry
    • Lyons, A. B., and C. R. Parish. 1994. Determination of lymphocyte division by flow cytometry. J. Immunol. Methods 171:131.
    • (1994) J. Immunol. Methods , vol.171 , pp. 131
    • Lyons, A.B.1    Parish, C.R.2
  • 38
    • 0028948205 scopus 로고
    • Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease
    • Chakkalath, H. R., C. M. Theodos, J. S. Markowitz, M. J. Grusby, L. H. Glimcher, and R. G. Titus. 1995. Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease. J. Infect. Dis. 171:1302.
    • (1995) J. Infect. Dis. , vol.171 , pp. 1302
    • Chakkalath, H.R.1    Theodos, C.M.2    Markowitz, J.S.3    Grusby, M.J.4    Glimcher, L.H.5    Titus, R.G.6
  • 40
    • 0034661678 scopus 로고    scopus 로고
    • IL-12 is required to maintain a Th1 response during Leishmania major infection
    • Park, A. Y., B. D. Hondowicz, and P. Scott. 2000. IL-12 is required to maintain a Th1 response during Leishmania major infection. J. Immunol. 165:896.
    • (2000) J. Immunol. , vol.165 , pp. 896
    • Park, A.Y.1    Hondowicz, B.D.2    Scott, P.3
  • 41
    • 0027939931 scopus 로고
    • Role of transcription factor NF-κB/Re1 in induction of nitric oxide synthase
    • Xie, Q. W., Y. Kashiwabara, and C. Nathan. 1994. Role of transcription factor NF-κB/Re1 in induction of nitric oxide synthase. J. Biol. Chem. 269:4705.
    • (1994) J. Biol. Chem. , vol.269 , pp. 4705
    • Xie, Q.W.1    Kashiwabara, Y.2    Nathan, C.3
  • 42
    • 0025191159 scopus 로고
    • Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism
    • Green, S. J., M. S. Meltzer, J. B. Hibbs, Jr., and C. A. Nacy. 1990. Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism. J. Immunol. 144:278.
    • (1990) J. Immunol. , vol.144 , pp. 278
    • Green, S.J.1    Meltzer, M.S.2    Hibbs J.B., Jr.3    Nacy, C.A.4
  • 43
    • 0025609915 scopus 로고
    • Tumor necrosis factor-α synergizes with IFN-γ in mediating killing of Leishmania major through the induction of nitric oxide
    • Liew, F. Y., Y. Li, and S. Millott. 1990. Tumor necrosis factor-α synergizes with IFN-γ in mediating killing of Leishmania major through the induction of nitric oxide. J. Immunol. 145:4306.
    • (1990) J. Immunol. , vol.145 , pp. 4306
    • Liew, F.Y.1    Li, Y.2    Millott, S.3
  • 46
    • 0030002111 scopus 로고    scopus 로고
    • Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response
    • Mattner, F., J. Magram, J. Ferrante, P. Launois, K. Di Padova, R. Behin, M. K. Gately, J. A. Louis. and G. Alber. 1996. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur. J. Immunol. 26:1553.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1553
    • Mattner, F.1    Magram, J.2    Ferrante, J.3    Launois, P.4    Di Padova, K.5    Behin, R.6    Gately, M.K.7    Louis, J.A.8    Alber, G.9
  • 48
    • 0037087436 scopus 로고    scopus 로고
    • Cutting edge: Identification of c-Re1-dependent and -independent pathways of IL-12 production during infectious and inflammatory stimuli
    • Mason. N., J. Aliberti, J. C. Caamaño, H. C. Liou, and C. A. Hunter. 2002. Cutting edge: identification of c-Re1-dependent and -independent pathways of IL-12 production during infectious and inflammatory stimuli. J. Immunol. 168: 2590.
    • (2002) J. Immunol. , vol.168 , pp. 2590
    • Mason, N.1    Aliberti, J.2    Caamaño, J.C.3    Liou, H.C.4    Hunter, C.A.5
  • 50
    • 0035070195 scopus 로고    scopus 로고
    • Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets
    • Grogan, J. L., M. Mohrs, B. Harmon, D. A. Lacy, J. W. Sedat, and R. M. Locksley. 2001. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 14:205.
    • (2001) Immunity , vol.14 , pp. 205
    • Grogan, J.L.1    Mohrs, M.2    Harmon, B.3    Lacy, D.A.4    Sedat, J.W.5    Locksley, R.M.6
  • 52
    • 0024580741 scopus 로고
    • Functionally distinct NF-κB binding sites in the immunoglobulin κ and IL-2 receptor α chain genes
    • Cross, S. L., N. F. Halden, M. J. Lenardo, and W. J. Leonard. 1989. Functionally distinct NF-κB binding sites in the immunoglobulin κ and IL-2 receptor α chain genes. Science 244:466.
    • (1989) Science , vol.244 , pp. 466
    • Cross, S.L.1    Halden, N.F.2    Lenardo, M.J.3    Leonard, W.J.4
  • 53
    • 0026332710 scopus 로고
    • Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-κB-like response element
    • Verweij, C. L., M. Geerts, and L. A. Aarden. 1991. Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-κB-like response element. J. Biol. Chem. 266:14179.
    • (1991) J. Biol. Chem. , vol.266 , pp. 14179
    • Verweij, C.L.1    Geerts, M.2    Aarden, L.A.3
  • 54
    • 0029000938 scopus 로고
    • Re1A is a potent transcriptional activator of the CD28 response element within the interleukin-2 promoter
    • Lai, J. H., G. Horvath, J. Subleski, J. Bruder, P. Ghosh, and T. H. Tan. 1995. Re1A is a potent transcriptional activator of the CD28 response element within the interleukin-2 promoter. Mol. Cell Biol. 15:4260.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 4260
    • Lai, J.H.1    Horvath, G.2    Subleski, J.3    Bruder, J.4    Ghosh, P.5    Tan, T.H.6
  • 56
    • 0030925372 scopus 로고    scopus 로고
    • Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor NF-κB
    • Boothby, M. R., A. L. Mora, D. C. Scherer, J. A. Brockman, and D. W. Ballard. 1997. Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor NF-κB. J. Exp. Med. 185:1897.
    • (1997) J. Exp. Med. , vol.185 , pp. 1897
    • Boothby, M.R.1    Mora, A.L.2    Scherer, D.C.3    Brockman, J.A.4    Ballard, D.W.5
  • 57
    • 0345593715 scopus 로고    scopus 로고
    • In vivo inhibition of NF-ΚB in T-lineage cells leads to a dramatic decrease in cell proliferation and cytokine production and to increased cell apoptosis in response to mitogenic stimuli, but not to abnormal thymopoiesis
    • Ferreira, V., N. Sidenius, N. Tarantino, P. Hubert, L. Chatenoud, F. Blasi, and M. Korner. 1999. In vivo inhibition of NF-ΚB in T-lineage cells leads to a dramatic decrease in cell proliferation and cytokine production and to increased cell apoptosis in response to mitogenic stimuli, but not to abnormal thymopoiesis. J. Immunol. 162:6442.
    • (1999) J. Immunol. , vol.162 , pp. 6442
    • Ferreira, V.1    Sidenius, N.2    Tarantino, N.3    Hubert, P.4    Chatenoud, L.5    Blasi, F.6    Korner, M.7
  • 58
    • 0035865046 scopus 로고    scopus 로고
    • NF-κB/Re1 participation in the lymphokine-dependent proliferation of T lymphoid cells
    • Mora, A., J. Youn, A. Keegan, and M. Boothby. 2001. NF-κB/Re1 participation in the lymphokine-dependent proliferation of T lymphoid cells. J. Immunol. 166:2218.
    • (2001) J. Immunol. , vol.166 , pp. 2218
    • Mora, A.1    Youn, J.2    Keegan, A.3    Boothby, M.4
  • 59
    • 0029150389 scopus 로고
    • Mice lacking the c-Re1 proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    • Kontgen, F., R. J. Grumont, A. Strasser, D. Metcalf, R. Li, D. Tarlinton, and S. Gerondakis. 1995. Mice lacking the c-Re1 proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9:1965
    • (1995) Genes Dev. , vol.9 , pp. 1965
    • Kontgen, F.1    Grumont, R.J.2    Strasser, A.3    Metcalf, D.4    Li, R.5    Tarlinton, D.6    Gerondakis, S.7
  • 60
    • 0030999057 scopus 로고    scopus 로고
    • NF-κB Re1A-deficient lymphocytes: Normal development of T cells and B cells, impaired production of IgA and IgG1, and reduced proliferative responses
    • Doi, T. S., T. Takahashi, O. Taguchi, T. Azuma, and Y. Obata. 1997. NF-κB Re1A-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1, and reduced proliferative responses. J. Exp. Me. 185:953.
    • (1997) J. Exp. Me. , vol.185 , pp. 953
    • Doi, T.S.1    Takahashi, T.2    Taguchi, O.3    Azuma, T.4    Obata, Y.5
  • 61
    • 0033023431 scopus 로고    scopus 로고
    • c-Re1 is crucial for lymphocyte proliferation but dispensable for T cell effector function
    • Liou, H. C., Z. Jin, J. Tumang, S. Andjelic, K. A. Smith, and M. L. Liou. 1999. c-Re1 is crucial for lymphocyte proliferation but dispensable for T cell effector function. Int. Immunol. 11:361.
    • (1999) Int. Immunol. , vol.11 , pp. 361
    • Liou, H.C.1    Jin, Z.2    Tumang, J.3    Andjelic, S.4    Smith, K.A.5    Liou, M.L.6
  • 62
    • 0025899598 scopus 로고
    • Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    • Schorle, H., T. Holtschke, T. Hunig, A. Schimpl, and I. Horak. 1991. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352:621.
    • (1991) Nature , vol.352 , pp. 621
    • Schorle, H.1    Holtschke, T.2    Hunig, T.3    Schimpl, A.4    Horak, I.5
  • 63
    • 0028784289 scopus 로고
    • Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
    • Willerford, D. M., J. Chen, J. A. Ferry, L. Davidson, A. Ma, and F. W. Alt. 1995. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3:521.
    • (1995) Immunity , vol.3 , pp. 521
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 65
    • 0026758170 scopus 로고
    • The candidate oncoprotein Bcl-3 is an antagonist of p50/ NF-κB-mediated inhibition
    • Franzoso, G., V. Bours, S. Park, M. Tomita-Yamaguchi, K. Kelly, and U. Siebenlist. 1992. The candidate oncoprotein Bcl-3 is an antagonist of p50/ NF-κB-mediated inhibition. Nature 359:339.
    • (1992) Nature , vol.359 , pp. 339
    • Franzoso, G.1    Bours, V.2    Park, S.3    Tomita-Yamaguchi, M.4    Kelly, K.5    Siebenlist, U.6
  • 67
    • 0032489828 scopus 로고    scopus 로고
    • Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-κB1) but expressing p50
    • Ishikawa, H., E. Claudio, D. Dambach, C. Raventos-Suarez, C. Ryan, and R. Bravo. 1998. Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-κB1) but expressing p50. J. Exp. Med. 187:985.
    • (1998) J. Exp. Med. , vol.187 , pp. 985
    • Ishikawa, H.1    Claudio, E.2    Dambach, D.3    Raventos-Suarez, C.4    Ryan, C.5    Bravo, R.6
  • 68
    • 0032588289 scopus 로고    scopus 로고
    • NF- κB1 (p50) is up-regulated in lipopolysaccharide tolerance and can block tumor necrosis factor gene expression
    • Kastenbauer, S., and H. W. Ziegler-Heitbrock. 1999. NF- κB1 (p50) is up-regulated in lipopolysaccharide tolerance and can block tumor necrosis factor gene expression. Infect. Immun. 67:1553.
    • (1999) Infect. Immun. , vol.67 , pp. 1553
    • Kastenbauer, S.1    Ziegler-Heitbrock, H.W.2
  • 69
    • 0026717450 scopus 로고
    • IL-2-induced signal transduction involves the activation of nuclear NF-κB expression
    • Arima, N., W. A. Kuziel, T. A. Grdina, and W. C. Greene. 1992. IL-2-induced signal transduction involves the activation of nuclear NF-κB expression. J. Immunol. 149:83.
    • (1992) J. Immunol. , vol.149 , pp. 83
    • Arima, N.1    Kuziel, W.A.2    Grdina, T.A.3    Greene, W.C.4
  • 70
    • 0031433362 scopus 로고    scopus 로고
    • An indirect effect of Stat5a in IL-2-induced proliferation: A critical role for Stat5a in IL-2-mediated IL-2 receptor α chain induction
    • Nakajima, H., X. W. Liu, A. Wynshaw-Boris, L. A. Rosenthal, K. Imada, D. S. Finbloom, L. Hennighausen, and W. J. Leonard. 1997. An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor α chain induction. Immunity 7:691.
    • (1997) Immunity , vol.7 , pp. 691
    • Nakajima, H.1    Liu, X.W.2    Wynshaw-Boris, A.3    Rosenthal, L.A.4    Imada, K.5    Finbloom, D.S.6    Hennighausen, L.7    Leonard, W.J.8
  • 71
    • 0030614504 scopus 로고    scopus 로고
    • Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator
    • Perkins, N. D., L. K. Felzien, J. C. Betts, K. Leung, D. H. Beach, and G. J. Nabel. 1997. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science 275:523.
    • (1997) Science , vol.275 , pp. 523
    • Perkins, N.D.1    Felzien, L.K.2    Betts, J.C.3    Leung, K.4    Beach, D.H.5    Nabel, G.J.6
  • 73
    • 0032588186 scopus 로고    scopus 로고
    • NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1
    • Guttridge, D. C., C. Albanese, J. Y. Reuther, R. G. Pestell, and A. S. Baldwin, Jr. 1999. NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell Biol. 19:5785.
    • (1999) Mol. Cell Biol. , vol.19 , pp. 5785
    • Guttridge, D.C.1    Albanese, C.2    Reuther, J.Y.3    Pestell, R.G.4    Baldwin A.S., Jr.5
  • 75
    • 0020544527 scopus 로고
    • Interleukin-2 deficiency in murine Leishmaniasis donovani and its relationship to depressed spleen cell responses to phytohemagglutinin
    • Reiner, N. E., and J. H. Finke. 1983. Interleukin-2 deficiency in murine Leishmaniasis donovani and its relationship to depressed spleen cell responses to phytohemagglutinin. J. Immunol. 131:1487.
    • (1983) J. Immunol. , vol.131 , pp. 1487
    • Reiner, N.E.1    Finke, J.H.2
  • 76
    • 0022968968 scopus 로고
    • Suppression of interleukin-2 production by macrophages in genetically susceptible mice infected with Leishmania major
    • Cillari, E., F. Y. Liew, and R. Lelchuk. 1986. Suppression of interleukin-2 production by macrophages in genetically susceptible mice infected with Leishmania major. Infect. Immun. 54:386.
    • (1986) Infect. Immun. , vol.54 , pp. 386
    • Cillari, E.1    Liew, F.Y.2    Lelchuk, R.3
  • 77
    • 0025352196 scopus 로고
    • IL-2: A cofactor for induction of activated macrophage resistance to infection
    • Belosevic, M., D. S. Finbloom, M. S. Meltzer, and C. A. Nacy. 1990. IL-2: a cofactor for induction of activated macrophage resistance to infection. J. Immunol. 145:831.
    • (1990) J. Immunol. , vol.145 , pp. 831
    • Belosevic, M.1    Finbloom, D.S.2    Meltzer, M.S.3    Nacy, C.A.4
  • 80
    • 0023467366 scopus 로고
    • In situ characterization of the cutaneous immune response in Ethiopian cutaneous leishmaniasis
    • Nilsen, R., and R. N. Mshana. 1987. In situ characterization of the cutaneous immune response in Ethiopian cutaneous leishmaniasis. Scand. J. Immunol. 26:503.
    • (1987) Scand. J. Immunol. , vol.26 , pp. 503
    • Nilsen, R.1    Mshana, R.N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.