Interleukin-10 functions in vitro and in vivo to inhibit bacterial DNA- induced secretion of interleukin-12

Journal of Interferon and Cytokine Research

Volumn 17, Issue 12, 1997, Pages 781-788

  Anitescu, Magdalena ^a   Chace, Jacqueline H ^a   Tuetken, Rebecca ^a   Yi, Ae Kyung ^a   Berg, Daniel J ^a   Krieg, Arthur M ^a,b   Cowdery, John S ^a,b,c  

^a UNIVERSITY OF IOWA   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

^c UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; INTERLEUKIN 10;

ANIMAL CELL; ARTICLE; IMMUNOREGULATION; IMMUNOSTIMULATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; SPLEEN CELL; TRANSCRIPTION REGULATION;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0031460399     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.1997.17.781     Document Type: Article

References (51)

1. MESSINA, J.P., GILKESON, G.S., and PISETSKY, D.S. (1991). Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J. Immunol. 147, 1759-1764.
2. KRIEG, A.M., YI, A.-K., MATSON, S., WALDSCHMIDT, T.J., BISHOP, G.A., TEASDALE, R., KORETZKY, G.A., and KLINMAN, D.M. (1995). CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374, 546-549.
3. YAMAMOTO, S., YAMAMOTO, T., KATAOKA, T., KURAMOTO, E., YANO, O., and TOKUNAGA, T. (1992). Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity. J. Immunol. 148, 4072-4076.
4. YAMAMOTO, S., YAMAMOTO, T., SHIMADA, S., KURAMOTO, E., YANO, O., KATAOKA, T., and TOKUNAGA, T. (1992). DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth. Microbiol. Immunol. 36, 983-997.
5. KLINMAN, D.M., YI, A.-K., BEAUCAGE, S.L., CONOVER, J., and KRIEG, A.M. (1996). CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon γ. Proc. Natl. Acad. Sci. USA 93, 2879-2883.
6. KRIEG, A.M. (1996). An innate immune defense mechanism based on the recognition of CpG motifs in microbial DNA. J. Lab. Clin. Med. 128, 128-133.
7. HALPERN, M.D., KURLANDER, R.J., and PISETSKY, D.S. (1996). Bacterial DNA induces murine interferon-γ production by stimulation of interleukin 12 and tumor necrosis factor-α. Cell. Immunol. 167, 72-78.
8. YI, A.-K., CHACE, J.H., COWDERY, J.S., and KRIEG, A.M. (1996). IFN-γ promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides. J. Immunol. 156, 558-564.
9. SONEHARA, K., SATTO, H., KURAMOTO, E., YAMAMOTO, S., YAMAMOTO, T., and TOKUNAGA, T. (1996). Hexamer palindromic oligonucleotides with 5′-CG-3′ motif(s) induce production of interferon. J. Interferon Cytokine Res. 16, 799-803.
10. PISETSKY, D.S. (1996). Immune activation by bacterial DNA: a new genetic code. Immunity 5, 303-310.
11. HEREMANS, H., VAN DAMME, J., DILLEN, C., DIJKMANS, R., and BILLIAU, A. (1990). Interferon γ, a mediator of lethal lipopolysaccharide-induced Scwartzman-like shock reactions in mice. J. Exp. Med. 171, 1853-1869.
12. OZMEN, L., PERICIN, M., HAKIMI, J., CHIZZONITE, R.A., WYSOCKA, M., TRINCHIERI, G., GATELY, M., and GAROTTA, G. (1994). Interleukin 12, interferon γ, and tumor necrosis factor α are the key cytokines of the generalized Shwartzman reaction. J. Exp. Med. 180, 907-915.
13. WYSOCKA, M., KUBIN, M., VIEIRA, L.Q., OZMEN, L., GAROTTA, G., SCOTT, P., and TRINCHIERI, G. (1995). Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25, 672-676.
14. KLINMAN, D.M., and STEINBERG, A.D. (1987). Systemic autoimmune disease arises from polyclonal B cell activation. J. Exp. Med. 165, 1755-1760.
15. COWDERY, J.S., JACOBI, S.M., PITTS, A.K., and TYLER, T.L. (1987). Defective B cell clonal regulation and autoantibody production in New Zealand black mice. J. Immunol. 138, 760-764.
16. KLINMAN, D.M. (1990). Polyclonal B cell activation in lupus-prone mice precedes and predicts the development of autoimmune disease. J. Clin. Invest. 86, 1249-1254.
17. GILKESON, G.S., GRUDIER, J.P., KAROUNOS, D.G., and PISETSKY, D.S. (1989). Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA. J. Immunol. 142, 1482-1486.
18. GILKESON, G.S., RUIZ, P., HOWELL, D., LEFKOWITH, J.B., and PISETSKY, D.S. (1993). Induction of immune-mediated glomerulonephritis in normal mice immunized with bacterial DNA. Clin. Immunol. Immunopathol. 68, 283-292.
19. TRINCHIERI, G. (1995). Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13, 251-276.
20. GAZZINELLI, R.T., WYSOCKA, M., HAYASHI, S., DENKERS, E.Y., HIENY, S., CASPAR, P., TRINCHIERI, G., and SHER, A. (1994). Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondil. J. Immunol. 153, 2533-2543.
21. ZHOU, P., SIEVE, M.C., BENNETT, J., KWON-CHUNG, K.J., TEWARE, R.P., GAZZINELLI, R.T., SHER, A., and SEDER, R.A. (1995). IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-γ. J. Immunol. 155, 785-795.
22. URBAN, J.F. JR., FAYER, R., CHEN, S.-J., GAUSE, W.C., GATELY, M.K., and FINKELMAN, F.D. (1996). IL-12 protects immunocompetent and immunodeficient neonatal mice against infection with Cryptosporidium parvum. J. Immunol. 156, 263-268.
23. FIORENTINO, D.F., ZLOTNIK, A., MOSMANN, T.R., HOWARD, M., and O'GARRA, A. (1991). IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147, 3815-3822.
24. D'ANDREA, A., ASTE-AMEZAGA, M., VALIANTE, N.M., MA, X., KUBIN, M., and TRINCHIERI, G. (1993). Interleukin 10 (IL-10) inhibits human lymphocyte interferon γ-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med. 178, 1041-1048.
25. PARK, D.R., and SKERRETT, S.J. (1996). IL-10 enhances the growth of Legionella pneumophila in human mononuclear phagocytes and reverses the protective effect of IFN-γ, differential responses of blood monocytes and alveolar macrophages. J. Immunol. 157, 2528-2538.
26. MURRAY, P.J., WANG, L., ONUFRYK, C., TEPPER, R.I., and YOUNG, R.A. (1997). T cell-derived IL-10 antagonizes macrophages function in mycobacterial infection. J. Immunol. 158, 315-321.
27. HOWARD, M., MUCHAMUEL, T., ANDRADE, S., and MENON, S. (1993). Interleukin 10 protects mice from lethal endotoxemia. J. Exp. Med. 177, 1205-1208.
28. VAN DER POLL, T., JANSEN, P.M., MONTEGUT, W.J., BRAXTON, C.C., CALVANO, S.E., STACKPOLE, S.A., SMITH, S.R., SWANSON, S.W., HACK, C.E., LOWRY, S.F., and MOLDAWER, L.L. (1997). Effects of IL-10 on systemic inflammatory responses during sublethal primate endotoxemia. J. Immunol. 158, 1971-1975.
29. BERG, D.J., KÜHN, R., RAJEWSKY, K., MÜLLER, W., MENON, S., DAVIDSON, N., GRÜNIG, G., and RENNICK, D. (1995). Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J. Clin. Invest. 96, 2339-2347.
30. COWDERY, J.S., CHACE, J.H., YI, A.-K., and KRIEG, A.M. (1996). Bacterial DNA induces NK cells to produce interferon-gamma in vivo and increases the toxicity of lipopolysaccharides. J. Immunol. 156, 4570-4575.
31. KLINMAN, D.M., YI, A.-K., BEAUCAGE, S.L., CONOVER, J., and KRIEG, A.M. (1996). CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12 and interferon γ. Proc. Natl. Acad. Sci. USA 93, 2879-2883.
32. SULLIVAN, J.D., VALOIS, F.W., and WATSON, S.W. (1976). Endotoxins: the limulus amebocyte lysate system. In: Mechanisms in Bacterial Toxicology. A.W. Bernheimer (ed.) New York: Wiley, p. 217.
33. COFFMAN, R.L. (1982). Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. Immunol. Rev. 69, 5-23.
34. SPRINGER, T., GALFRE, G., SECHER, D.S., and MILSTEIN, C. (1978). Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. Eur. J. Immunol. 8, 539-551.
35. LOGDBERG, L., WASSMER, P., and SHEVACH, E.M. (1985). Role of the L3T4 antigen in T cell activation. I. Description of a monoclonal IgM antibody to a distinct epitope (L3T4B) of the L3T4 antigen and its effect on interleukin 1 induced thymocyte proliferation. Cell. Immunol. 94, 299-311.
36. LEDBETTER, J.A., and HERZENBERG, L.A. (1979). Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol. Rev. 47, 63-90.
37. SEDGWICK, J.E., and HOLT, P.G. (1983). A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells. J. Immunol. Methods 57, 301-309.
38. + T cells from young and old mice. J. Immunol. 150, 3602-3614.
39. YI, A-K, KLINMAN, D.M., MARTIN, T.L., MATSON, S., and KRIEG, A.M. (1996). Rapid immune activation by CpG Motifs in bacterial DNA: systemic induction of IL-6 transcription through an antioxidant-sensitive pathway. J. Immunol. 157, 5394-5402.
40. RAJCHEL, A., CHAN, Y.L., and WOOL, I.G. (1988). The primary structure of rat ribosomal protein L32. Nucleic Acids 16, 2347.
41. CHACE, J.H., HOOKER, N.A., MILDENSTEIN, K.L., KRIEG, A.M., and COWDERY, J.S. (1997). Bacterial DNA-induced NK cell IFN-γ production is dependent on macrophage secretion of IL-12. Clin. Immunol. Immunopathol. 84, 185-193.
42. AUTENRIETH, I.B., BEER, M., BOHN, E., KAUFMANN, S.H.E., and HEESEMANN, J. (1994). Immune responses to Yersinia enterocolitica in susceptible BALB/c and resistant C57BL/6 mice: an essential role for gamma interferon. Infect. Immun. 62, 2590-2599.
43. COOPER, A.M., DALTON, D.K., STEWART, T.A., GRIFFIN, J.P., RUSSELL, D.G., and ORME, I.M. (1993). Disseminated tuberculosis in interferon γ gene-disrupted mice. J. Exp. Med. 178, 2243-2247.
44. HEREMANS, H., DIJKMANS, R., SOBIS, H., VANDEKERCKHOVE, F., and BILLIAU, A. (1987). Regulation of interferons of the local inflammatory response to bacterial lipopolysaccharide. J. Immunol. 138, 4175-4179.
45. DEBETS, J.M.H., KAMPMEIJER, R., VAN DER LINDEN, M.P.M.H., BUURMAN, W.A., and VAN DER LINDEN, C.J. (1989). Plasma tumor necrosis factor and mortality in critically ill septic patients. J. Crit. Care 17, 489-494.
46. WAAGE, A., HALSTENSEN, A., ESPEVIK, T. (1987). Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease. Lancet 1, 355-357.
47. + T cells and accompanied by overproduction of IL-12, IFN-γ, and TNF-α. J. Immunol. 157, 798-805.
48. DONNELLY, S.C., STRIETER, R.M., REID, P.T., KUNKEL, S.L., BURDICK, M.D., ARMSTRONG, I., MACKENZIE, A., and HASLETT, C. (1996). The association between mortality rates and decreased concentrations of interleukin-10 and interleukin-1 receptor antagonist in the lung fluids of patients with the adult respiratory distress syndrome. Ann. Intern. Med. 125, 191-196.
49. STACY, K.J., SWEET, M.J., and HUME, D.A. (1996). Macrophages ingest and are activated by bacterial DNA. J. Immunol. 157, 2116-2122.
50. MURPHY, T., CLEVELAND, M.G., KULEZA, P., MAGRAM, J., and MURPHY, K.M. (1995). Regulation of IL-12 p40 expression through an NF-κB half site. Mol. Cell. Biol. 15, 5258-5267.
51. SATO, Y., ROMAN, M., TIGHE, H., LEE, D., CORR, M., NGUYEN, M., SILVERMAN, G.J., LOTZ, M., CARSON, D.A., and RAZ, E. (1996). Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273, 352-354.