Differentiation, regulation, and death of T helper cell subsets during infection with Leishmania major

Immunologic Research

Volumn 17, Issue 1-2, 1998, Pages 229-238

  Scott, Phillip ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Apoptosis; IL12; IL12 receptors; Leishmania major; Th subsets; Th1 cells; Th2 cells; TNF; TNF receptors; Vaccine

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; INTERLEUKIN 12; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; HELPER CELL; IMMUNOREGULATION; LEISHMANIA MAJOR; LEISHMANIASIS; MOUSE; NONHUMAN; PARASITE IMMUNITY; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 0031918448     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02786447     Document Type: Article

References (53)

1. Locksley RM, Scott P: Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function. Immunol Today 1991;12:A58-A61.
2. Scott P: T helper cell development and regulation in experimental cutaneous leishmaniasis. Chem Immunol 1996;63:98-114.
3. Reiner SL, Locksley RM: The regulation of immunity to Leishmania major. Annu Rev Immunol 1995;13:151-177.
4. Scott P: T cell subsets and T cell antigens in protective immunity against experimental leishmaniasis. Curr Topics Microbiol Immunol 1990;155:35-52.
5. Scott P: The role of Th1 and Th2 cells in experimental cutaneous leishmaniasis. Exp Parasitol 1989;68:369-372.
6. Scott P, Natovitz P, Coffman RL, Pearce E, Sher A: Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J Exp Med 1988;168:1675-1684.
7. Heinzel FP, Sadick MD, Holaday BJ, Coffman RL, Locksley RM: Reciprocal expression of interferon gamma or IL4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med 1989;169:59-72.
8. Scott P: IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. J Immunol 1991;147:3149-3155.
9. Chatelain R, Varkila K, Coffman RL: IL-4 induces a Th2 response in Leishmania major-infected mice. J Immunol 1992;148:1182-1187.
10. Reiner SL, Wang Z-E, Hatam F, Scott P, Locksley RM: Common lineage of Th1 and Th2 subsets in leishmaniasis. Science 1993;259: 1457-1460.
11. Scott P, Caspar P, Sher A: Protection against Leishmania major in BALB/c mice by adoptive transfer of a T cell clone recognizing a low molecular weight antigen released by promastigotes. J Immunol 1990;144:1075-1079.
12. Julia V, Rassoulzadegan M, Glaichenhaus N: Resistance to Leishmania major induced by tolerance to a single antigen. Science 1996; 274:421-423.
13. Scott P: Selective activation of CD4+ T cell subsets. Curr Opinions Immunol 1993;5:391-397.
14. Scharton- Kersten T, Afonso LCC, Wysocka M, Trinchieri G, Scott P: IL-12 is required for Natural Killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J Immunol 1995;154:5320-5330.
15. Scharton-Kersten T, Scott P: The role of the innate immune response in Th1 cell development following Leishmania major infection. J Leukocyte Biol 1995;57:515-522.
16. Heinzel FP, Rerko RM, Ahmed F, Pearlman E: Endogenous IL-12 is required for control of Th2 cytokine responses. J Immunol 1995; 155:730-739.
17. Sypek JP, Chung CL, Mayor SEH, Subramanyam JM, Goldman SJ, Sieburth DS, et al.: Resolution of cutaneous leishmaniasis: Interleukin 12 initiates a protective Th1 immune response. J Exp Med 1993;177:1797-1802.
18. Scott P: IL-12: Initiation cytokine for cell-mediated immunity. Science 1993;260:496,497.
19. O'Garra A, Murphy K: Role of cytokines in determining T-lymphocyte function. Curr Opinions Immunol 1994;6:458-466.
20. Scott P, Eaton A, Gause WC, Zhou XD, Hondowicz B: Early IL-4 production does not predict susceptibility to Leishmania major. Exp Parasitol 1996;84:178-187.
21. Afonso LCC, Scharton TM, Vieira LQ, Wysocka M, Trinchieri G, Scott P: The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 1994; 263:235-237.
22. Scharton TM, Scott P: Natural killer cells are a source of IFN-g that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice. J Exp Med 1993;178:567-577.
23. Gajewski TF, Fitch FW: Anti-proliferative effect of IIFN-γ in immune regulation. I. IFN-γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J Immunol 1988;140: 4245-4240.
24. Fiorentino DF, Zlotnik A, Vieira P, Mosmann TR, Howard M, Moore KW, et al.: IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol 1991;146:3444-3451.
25. Parish CR: Immune deviation: A historical perspective. Immunol Cell Biol 1996;74:449-456.
26. Liew FY, Hale C, Howard JG: Immunologic regulation of experimental cutaneous leishmaniasis. V. Characterization of effector and specific suppressor T cells. J Immunol 1982;128:1917-1922.
27. Nabors GS, Afonso LCC, Farrell JP, Scott P: Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin-12 and pentostam. Proc Natl Acad Sci USA 1995;92:3142-3146.
28. Hondowicz B, Scott P: The role of IL-12 in modulating an established Th2 response in experimental leishmaniasis. Res Immunol 1996; 146:560-565.
29. Bogdan C, Nathan C: Modulation of macrophage function by transforming growth factor beta, interleukin-4 and interleukin-10. Ann NY Acad Sci 1993;685:713-739.
30. D'Andrea A, Ma X, Aste-Amezaga M, Paganin C, Trincheiri G: Stimulatory and inhibitory effects of IL-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor-α production. J Exp Med 1995; 181:537-546.
31. Barral-Netto M, Barral A, Brownell CE, Skeiky YAW, Ellingsworth LR, Twardzik DR, et al.: Transforming growth factor-β in leishmanial infection: A parasite escape mechanism. Science 1992; 257:545-548.
32. Stenger S, Thuring H, Rollinghoff M, Bogdan C: Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major. J Exp Med 1994;180:783-793.
33. Li J, Scott P, Farrell JP: In vivo alterations in cytokine production following interleukin-12 (IL-12) and anti-IL-4 antibody treatment of CB6F1 mice with chronic cutaneous leishmaniasis. Infect Immunol 1996;64:5248-5254.
34. Boyer MH, Jaffe CL: Increased susceptibility to Leishmania tropica infection in autoimmune MRL/MpJ-lpr mice. J Parasitol 1984;70:145,146.
35. Pfeffer K, Matsuyama T, Kundig TM, Wakeham A, Kishihara K, Shahinian A, et al.: Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 1993;73:457-467.
36. Rothe J, Lesslauer W, Loetscher H, Lang Y, Koebel P, Koentgen F, et al.: Mice lucking the tumor necrosis receptor I are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature 1993;364: 798-800.
37. Erickson SL, de Sauvage FJ, Kikly K, Carver-Moore K, Pitts-Meek S, Gillett N, et al.: Decreased sensitivity to tumor-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice. Nature 1994;372:560-563.
38. Flynn JL, Goldstein MM, Chan J, Triebold KJ, Pfeffer K, Lowenstein CJ, Schreiber R, et al.: Tumor necrosis factor-α is required for the protective immune response against Mycobacterium tuberculosis in mice. Immunity 1995;2:561-572.
39. Vieira LQ, Goldschmidt M, Nashleunas M, Pfeffer K, Mak T, Scott P: Mice lacking the TNF receptor p55 fail to resolve lesions caused by infection with Leishmania major, but control parasite replication. J Immunol 1996;157:827-835.
40. Zhou T, Edwards CK, Yang P, Wang Z, Bluethmann H, Mountz JD: Greatly acclerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor I. J Immunol 1996; 156:2661-2665.
41. Sytwu H-K, Liblau RS, McDevitt HO: The role of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice. Immunity 1996; 5:17-30.
42. Singer GG, Abbas AK: The fas antigen in involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1994;1:365-371.
43. Prescott JF, Hoffman AM: Rhodococcus equi. Vet Clin North America-Equine Pract 1993;9:375-384.
44. Verville TD, Huycke MM, Greenfield RA, Fine DP, Kuhls TL, Slater LN: Rhodococcus equi infections in humans. Medicine 1994;73:119-132.
45. Kanaly ST, Hines SA, Palmer GH: Cytokine modulation alters pulmonary clearance of Rhodococcus equi and development of granulomatous pneumonia. Infect Immun 1995; 63:3037-3041.
46. Kanaly ST, Hines SA, Palmer GH: Transfer of a CD4+ Th1 cell line to nude mice effects clearance of Rhodococcus equi from the lung. Infect Immun 1996;64:1126-1132.
47. Green SJ, Meltzer MS, Hibbs JB, Jr., Nacy CA: Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism. J Immunol 1990;144: 278-283.
48. Liew FY, Li Y, Millott S: Tumour necrosis factor (TNF-alpha) in leishmaniasis. II. TNF-alpha-induced macrophage leishmanicidal activity is mediated by nitric oxide from L-arginine. Immunology 1990;71:556-559.
49. Wei X-Q, Charles IG, Smith A, Ure J, Feng G-J, Huang F-P, et al.: Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 1995;375:408-411.
50. Green SJ, Crawford RM, Hockmeyer JT, Meltzer MS, Nacy CA: Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha. J Immunol 1990;145:4290-4297.
51. Bogdan C, Moll H, Solbach W, Rollinghoff M: Tumor necrosis factor-alpha in combination with interferon-gamma, but not with interleukin 4 activates murine macrophages for elimination of Leishmania major amastigotes. Eur J Immunol 1990;20:1131-1135.
52. Vieira LQ, Hondowicz BD, Afonso LCC, Wysocka M, Trinchieri G, Scott P: Infection with Leishmania major induces interleukin-12 production in vivo. Immunol Letters 1994;40:157-161.
53. Sartori A, Oliveira M, Scott P, Trinchieri G: Metacyclogenesis modulates the ability of Leishmania promastigotes to induce interleukin-12 production in human mononuclear cells. J Immunol 1997;159:2849-2857.