NF-κB1 (p50) is upregulated in lipopolysaccharide tolerance and can block tumor necrosis factor gene expression

Infection and Immunity

Volumn 67, Issue 4, 1999, Pages 1553-1559

  Kastenbauer, Stefan ^a   Ziegler Heitbrock, H W Löms ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; TUMOR NECROSIS FACTOR; LIPOPOLYSACCHARIDE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; KIDNEY CELL; PRIORITY JOURNAL; PROTEIN DNA BINDING; TRANSACTIVATION; BIOSYNTHESIS; CELL LINE; CELL NUCLEUS; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METABOLISM; PROMOTER REGION; REPORTER GENE; UPREGULATION;

CELL LINE; CELL LINE, TRANSFORMED; CELL NUCLEUS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; IMMUNE TOLERANCE; LIPOPOLYSACCHARIDES; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; PROMOTER REGIONS (GENETICS); TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 0032588289     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/.67.4.1553-1559.1999     Document Type: Article

References (46)

1. Blackwell, T. S., T. R. Blackwell, and J. W. Christman. 1997. Induction of endotoxin tolerance depletes nuclear factor-κB and suppresses its activation in rat alveolar macrophages. J. Leukoc. Biol. 62:885-891.
2. Coffee, K. A., P. V. Halushka, S. H. Ashton, G. E. Tempel, W. C. Wise, and J. A. Cook. 1992. Endotoxin tolerance is associated with altered GTP-binding protein function. J. Appl. Physiol. 73:1008-1013.
3. Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
4. Durando, M., S. H. Ashton, M. A. Makhlouf, R. Simmons-Wagner, P. V. Halushka, and J. A. Cook. 1997. Endotoxin-induced desensitization of THP-1 cells is not associated with altered G protein binding or content. J. Endotoxin Res. 4:97-103.
5. Ertel, W., J.-P. Kremer, J. Kenney, U. Steckholzer, D. Jarrar, O. Trentz, and F. W. Schildberg. 1995. Downregulation of proinflammatory cytokine release in whole blood from septic patients. Blood 85:1341-1347.
6. Frankenberger, M., H. Pechumer, and H. W. L. Ziegler-Heitbrock. 1995. Interleukin-10 is upregulated in LPS tolerance. J. Inflamm. 45:56-63.
7. Frankenberger, M., A. Pforte, T. Sternsdorf, B. Passlick, P. A. Baeuerle, and H. W. L. Ziegler-Heitbrock. 1994. Constitutive nuclear NF-κB in cells of the monocyte lineage. Biochem. J. 304:87-94.
8. Frankenberger, M., and H. W. L. Ziegler-Heitbrock. 1997. LPS tolerance in monocyte/macrophages: three 3′ cytospins are required in the DNA binding motif for detection of upregulated NF-κB p50 homodimers. Immunobiology 198:81-90.
9. Franzoso, G., V. Bours, S. Park, M. Tomita-Yamaguchi, K. Kelly, and U. Siebenlist. 1992. The candidate oncoprotein Bcl-3 is an antagonist of p50/ NF-κB-mediated inhibition. Nature 359:339-342.
10. Goldring, C. E., S. Reveneau, D. Pinard, and J. F. Jeannin. 1998. Hyporesponsiveness to lipopolysaccharide alters the composition of NF-kappaB binding to the regulatory regions of inducible nitric oxide synthase gene. Eur. J. Immunol. 28:2960-2970.
11. Haas, J. G., P. A. Bäuerle, G. Riethmüller, and H. W. L. Ziegler-Heitbrock. 1990. Molecular mechanisms in down-regulation of tumor necrosis factor expression. Proc. Natl. Acad. Sci. USA 87:9563-9567.
12. Hausdorff, W. P., M. G. Caron, and R. J. Lefkowitz. 1990. Turning off the signal: desensitization of β-adrenergic receptor function. FASEB J. 4:2881-2889.
13. Hirohashi, N., and D. C. Morrison. 1996. Low-dose lipopolysaccharide (LPS) pretreatment of mouse macrophages modulates LPS-dependent interleukin-6 production in vitro. Infect. Immun. 64:1011-1015.
14. + T lymphocytes. Science 256:1452-1456.
15. Kastenbauer, S., A. Wedel, M. Frankenberger, T. Wirth, and H. W. L. Ziegler-Heitbrock. 1996. Analysis of promoter activity by polymerase chain reaction amplification of reporter gene mRNA. Anal. Biochem. 233:137-139.
16. Kohler, N. G., and A. Joly. 1997. The involvement of an LPS inducible IκB kinase in endotoxin tolerance. Biochem. Biophy. Res. Commun. 232:602-607.
17. Labeta, M. O., J.-J. Durieux, G. Spagnoli, N. Fernandez, J. Wijdenes, and R. Herrmann. 1993. CD14 and tolerance to lipopolysaccharide: biochemical and functional analysis. Immunology 80:415-423.
18. Lægreid, A., L. Thommesen, T. Gullstein Jahr, A. Sundan, and T. Espevik. 1995. Tumor necrosis factor induces lipopolysaccharide tolerance in a human adenocarcinoma cell line mainly through the TNF p55 receptor. J. Biol. Chem. 270:25418-25425.
19. LaRue, K. E. A., and C. E. McCall. 1994. A labile transcriptional repressor modulates endotoxin tolerance. J. Exp. Med. 180:2269-2275.
20. Marchant, A., C. Gueydan, L. Houzet, Z. Amraoui, A. Sels, G. Huez, M. Goldman, and V. Kruys. 1996. Defective translation of tumor necrosis factor mRNA in lipopolysaccharide-tolerant macrophages. J. Inflamm. 46:114-123.
21. Mathison, J. C., G. D. Virca, E. Wolfson, P. S. Tobias, K. Glaser, and R. J. Ulevitch. 1990. Adaptation to bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages. J. Clin. Investig. 85:1108-1118.
22. Mathison, J., E. Wolfson, S. Steinemann, P. Tobias, and R. Ulevitch. 1993. Lipopolysaccharide (LPS) recognition in macrophages. J. Clin. Investig. 92: 2053-2059.
23. Munoz, C., J. Carlet, C. Fitting, B. Bisset, J.-P. Blériot, and J.-M. Cavaillon. 1991. Dysregulation of in vitro cytokine production by monocytes during sepsis. J. Clin. Investig. 88:1747-1754.
24. Pechumer, H., C. Bender-Götze, and H. W. L. Ziegler-Heitbrock. 1993. Detection of neuron specific gamma enolase (NSE) mRNA in normal human leukocytes by PCR with nested primers. Lab. Investig. 69:743-749.
25. Pope, R. M., A. Leutz, and S. A. Ness. 1994. C/EBP beta regulation of the tumor necrosis factor alpha gene. J. Clin. Investig. 94:1449-1455.
26. Schmitz, M. L., and P. A. Bäuerle. 1991. The p65 subunit is responsible for the strong transcription activating potential of NF-κB. EMBO J. 10:3805-3817.
27. Shakov, A. N., M. A. Collart, P. Vassalli, S. A. Nedospasov, and C. V. Jongeneel. 1990. κB-type enhancers are involved in LPS-mediated transcriptional activation of the TNF-α gene in primary macrophages. J. Exp. Med. 171:35-47.
28. + T cells express perturbed AP-1 and NF-κB transcription factors. Proc. Natl. Acad. Sci. USA 93:979-984.
29. 4 in chemotactic peptide-stimulated human neutrophils. FASEB J. 12:1521-1531.
30. Trede, N. S., A. V. Tsytsykova, T. Chatila, A. E. Goldfeld, and R. S. Geha. 1995. Transcriptional activation of the human TNF-α promoter by superantigen in human monocytic cells: role of NF-κB. J. Immunol. 155:902-908
31. Virca, G. D., S. Y. Kim, K. B. Glaser, and R. J. Ulevitch. 1989. Lipopolysaccharide induces hyporesponsiveness to its own action in RAW 264.7 cells. J. Biol. Chem. 264:21951-21956.
32. Wedel, A., G. Sulski, and H. W. L. Ziegler-Heitbrock. 1996. CCAAT/enhancer binding protein is involved in the expression of the tumor necrosis factor gene in human monocytes. Cytokine 8:335-341.
33. Wilson, C. S., S. C. Seatter, J. L. Rodriguez, J. Bellingham, L. Clair, and M. A. West. 1997. In vivo endotoxin tolerance: impaired LPS-stimulated TNF release of monocytes from patients with sepsis, but not SIRS. J. Surg. Res. 69:101-106.
34. Worthen, G. S., J. F. Seccombe, K. L. Clay, L. A. Guthrie, and R. Johnston. 1988. The priming of neutrophils by lipopolysaccharide for production of intracellular platelet-activating factor. Potential role in mediation of enhanced superoxide secretion. J. Immunol. 140:3553-3559.
35. Wright, S. D., R. A. Ramos, P. S. Robias, R. J. Ulevitch, and J. C. Mathison. 1990. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431-1433.
36. Yao, J., N. Mackman, T. S. Edgington, and S.-T. Fan. 1997. Lipopolysaccharide induction of the tumor necrosis factor-α promoter in human monocytic cells. J. Biol. Chem. 272:17795-17801.
37. Ziegler-Heitbrock, H. W. L. 1995. Molecular mechanism in tolerance to lipopolysaccharide. J. Inflamm. 45:13-26.
38. Ziegler-Heitbrock, H. W. L., and R. Burger. 1987. Rapid removal of mycoplasma from cell lines mediated by a direct effect of complement. Exp. Cell Res. 173:388-394.
39. Ziegler-Heitbrock, H. W. L., M. Frankenberger, and A. Wedel. 1995. Tolerance to lipopolysaccharide in human blood monocytes. Immunobiology 193: 217-223.
40. Ziegler-Heitbrock, H. W. L., E. Käfferlein, J. G. Haas, N. Meyer, M. Ströbel, C. Weber, and D. Flieger. 1992. Gangliosides suppress tumor necrosis factor production in human monocytes. J. Immunol. 148:1753-1758.
41. Ziegler-Heitbrock, H. W. L., I. Petersmann, and M. Frankenberger. 1997. p50 (NF-κB1) is upregulated in LPS tolerant P388D1 murine macrophages. Immunobiology 198:73-80.
42. Ziegler-Heitbrock, H. W. L., T. Sternsdorf, J. Liese, B. Belohradsky, C. Weber, A. Wedel, R. Schreck, P. Bäuerle, and M. Ströbel. 1993. Pyrrolidine dithiocarbamate inhibits NF-κB mobilization and TNF production in human monocytes. J. Immunol. 151:6986-6993.
43. Ziegler-Heitbrock, H. W. L., E. Thiel, A. Fütterer, V. Herzog, A. Wirtz, and G. Riethmüller. 1988. Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes. Int. J. Cancer 41:456-461.
44. Ziegler-Heitbrock, H. W. L., and R. J. Ulevitch. 1993. CD14: cell surface receptor and differentiation marker. Immunol. Today 14:121-125.
45. Ziegler-Heitbrock, H. W. L., A. Wedel, W. Schraut, M. Ströbel, P. Wendelgass, T. Sternsdorf, P. Bäuerle, J. G. Haas, and G. Riethmüller. 1994. Tolerance to lipopolysaccharide involves mobilization of nuclear factor κB with predominance of p50 homodimers. J. Biol. Chem. 269:17001-17004.
46. Zuckerman, S. H., G. F. Evans, Y. M. Snyder, and W. D. Roeder. 1989. Endotoxin-macrophage interaction: post-translational regulation of tumor necrosis factor expression. J. Immunol. 143:1223-1227.