The NF-κB family member RelB is required for innate and adaptive immunity to Toxoplasma gondii

Journal of Immunology

Volumn 163, Issue 8, 1999, Pages 4453-4461

  Caamaño, Jorge ^a   Alexander, James ^b   Craig, Linden ^a   Bravo, Rodrigo ^c   Hunter, Christopher A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12;

ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CYTOKINE PRODUCTION; FEMALE; IMMUNOREGULATION; INFECTION RESISTANCE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TOXOPLASMA GONDII;

EID: 0032864097     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (64)

1. Fearon, D. T., and R. M. Locksley. 1996. The instructive role of innate immunity in the acquired immune response. Science 272:50.
2. Medzhitov, R., and C. A. Janeway. 1997. Innate immunity: impact on the adaptive immune response. Curr. Opin. Immunol. 9:4.
3. Bancroft, G. J. 1993. The role of natural killer cells in innate resistance to infection. Curr. Opin. Immunol. 5:503.
4. Biron, C. A., and R. T. Gazzinelli. 1995. Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome. Curr. Opin. Immunol. 7:485.
5. Scott, P., and G. Trinchieri. 1995. The role of natural killer cells in host-parasite interactions. Curr. Opin. Immunol. 7:34.
6. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
7. Hunter, C. A., R. Chizzonite, and J. S. Remington. 1995. Interleukin 1β is required for the ability of IL-12 to induce production of IFN-γ by NK cells: A role for IL-1β in the T cell independent mechanism of resistance against intracellular pathogens. J. Immunol. 155:4347.
8. Hunter, C. A., L. Ellis-Neyer, K. Gabriel, M. Kennedy, P. Linsley, and J. S. Remington. 1997. The role of the CD28/B7 interaction in the regulation of NK cell responses during infection with Toxoplasma gondii. J. Immunol. 158:2285.
9. Tripp, C. S., S. F. Wolf, and E. R. Unanue. 1993. Interleukin 12 and tumor necrosis factor α are costimulators of interferon γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiological antagonist. Proc. Natl. Acad. Sci. USA 90:3725.
10. Sher, A., I. P. Oswald, S. Hieny, and R. Gazzinelli. 1993. Toxoplasma gondii induces a T-independent IFN-γ response in natural killer cells that requires both adherent accessory cells and tumor necrosis factor-α. J. Immunol. 150:3982.
11. O'Garra, A. 1998. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8:275.
12. Janeway, C. A., and K. Bottomly. 1994. Signals and signs for lymphocyte responses. Cell 76:275.
13. Dushay, M. S., B. Asling, and D. Hultmark. 1996. Origins of immunity: relish, a compound Rel-like gene in the antibacterial defense of Drosophila. Proc. Natl. Acad. Sci. USA 93:10343.
14. Medzhitov, R., P. Preston-Hurlburt, and C. A. Janeway. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388:394.
15. Hultmark, D. 1993. Immune reactions in Drosophila and other insects: a model for innate immunity. Trends Genet. 9:178.
16. Ghosh, S., M. J. May, and E. B. Kopp. 1998. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16: 225.
17. May, M. J., and S. Ghosh. 1998. Signal transduction through NF-κB. Immunol. Today 19:80.
18. Toosi, Z., B. D. Hamilton, M. H. Phillips, L. E. Averill, J. J. Ellner, and A. Salvekar. 1997. Regulation of nuclear factor-κB and its inhibitor IκB-α/ MAD-3 in monocytes by Mycobacterium tuberculosis and during human tuberculosis. J. Immunol. 159:4109.
19. Ebnet, K., K. D. Brown, U. K. Siebenlist, M. M. Simon, and S. Shaw. 1997. Borrelia burgdorferi activates nuclear factor-κB and is a potent inducer of chemokine and adhesion molecule gene expression in endothelial cells and fibroblasts. J. Immunol. 158:3285.
20. Naumann, M., S. Wessler, C. Bartsch, B. Wieland, and T. F. Meyer. 1997. Neisseria gonorrhoeae epithelial cell interaction leads to the activation of the transcription factors nuclear factor κB and activatory protein 1 and the induction of inflammatory cytokines. J. Exp. Med. 186:247.
21. Geng, Y., B. Zhang, and M. Lotz. 1993. Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes. J. Immunol. 151:6692.
22. Lousie, C. B., M. C. Tran, and T. G. Obrig. 1997. Sensitization of human umbilical vein endothelial cells to shiga toxin: involvement of protein kinase C and NF-κB. Infect. Immun. 65:3337.
23. Robinson, D., K. Shibuya, A. Mui, F. Zonin, E. Murphy, T. Sana, S. B. Hartley, S. Menon, R. Kastelein, F. Bazan, and A. O'Garra. 1997. IG1F does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NF-κB. Immunity 7:571.
24. Carrasco, D., R. P. Ryseck, and R. Bravo. 1993. Expression of relB transcripts during lymphoid organ development: specific expression in dendritic antigen-presenting cells. Development 118:1221.
25. Lernbecher, T., U. Muller, and T. Wirth. 1994. Distinct NF-κB/Rel transcription factors are responsible for tissue-specific and inducible gene activation. Nature 365:767.
26. Ishikawa, H., D. Carrasco, E. Claudio, R.-P. Ryseck, and R. Bravo. 1997. Gastric hyperplasia and increased prolierative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-κB. J. Exp. Med. 186:999.
27. Gerondakis, S., R. Grumont, I. Rourke, and M. Grossmann. 1998 The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation. Curr. Opin. Immunol. 10:353.
28. Attar, R. M., J. Caamano, D. Carrasco, V. Iotsova, H. Ishikawa, R. P. Ryseck, F. Weih, and R. Bravo. 1997. Genetic approaches to study Rel/NF-κB/IκB function in mice. Semin. Cancer Biol. 8:93.
29. Weih, F., D. Carrasco, and R. Bravo. 1994. Constitutive and inducible Rel/NF-κB activities in mouse thymus and spleen. Oncogene 9:3289.
30. Granelli-Piperno, A., M. Pope, K. Inaba, and R. M. Steinman. 1995. Coexpression of NF-κB/Rel and Sp1 transcription factors in human immunodeficiency virus 1-induced, dendritic cell-T-cell syncytia. Proc. Natl. Acad. Sci. USA 92:10944.
31. + dendritic cells. Immunity 9:839.
32. Burkly, L., C. Hesslon, L. Ogata, C. Reilly, L. A. Marconi, D. Olson, R. Tizard, R. Cate, and D. Lo. 1995. Expression of relB is required for the development of thymic medulla and denditic cells. Nature 373:531.
33. Weih, F., D. Carrasco, S. K. Durham, D. S. Barton, C. A. Rizzo, R.-P. Ryseck, S. A. Lira, and R. Bravo. 1995. Mutiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/ Rel family. Cell 80:331.
34. Weih, F., S. K. Durham, D. S. Barton, W. C. Sha, D. Baltimore, and R. Bravo. 1996. Both mutiorgan inflammation and myeloid hyperplasia in RelB-deficient mice are T cell dependent. J. Immunol. 157:3974.
35. Xia, Y., M. E. Pauza, L. Feng, and D. Lo. 1997. RelB regulation of chemokine expression modulates local inflammation. Am. J. Pathol. 151:375.
36. Sousa, C. R., S. Hieny, T. Scharton-Kersten, D. Jankovic, H. Charset, R, N. Germain, and A. Sher. 1997. In vivo microbial stimulation induces rapid CD40 ligand-independent production of intcrleukin 12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med. 186:1819.
37. Weih, F., G. Warr, H. Yang, and R. Bravo. 1997. Multifocal defects in immune responses in RelB-deficient mice J. Immunol. 158:5211.
38. Sharma, S. D., J. Mullenax, F. G. Araujo, A. A. Erlich, and J. S. Remington. 1983. Western blot analysis of the antigens of Toxoplasma gondii recognized by human IgM and IgG antibodies. J. Immunol. 131:977.
39. Conley, F. K., and Jenkins, K. A. 1981. Immunohistological study of the anatomic relationship of toxoplasma antigens to the inflammatory response in the brains of mice chronically infected with Toxoplasma gondii. Infect. Immun. 31:1184.
40. Abrams, J. S., M. G. Roncarolo, H. Yssel, G. J. Andersson, and J. E. Silver. 1992. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127:5.
41. Sander, B., I. Hoiden, U. Andersson, E. Moller, and J. S. Abrams. 1993. Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen. J. Immunol. Methods 166:201.
42. Candolfi, E, C. A. Hunter, and J. S. Remington. 1995. Roles of γ interferon and other cytokines in suppression of the spleen cell proliferative response to concanavlin A and Toxoplasma antigen during acute toxoplasmosis. Infect. Immun. 63:751.
43. Hunter, C. A., C. S. Subauste, V. H. Van Cleave, and J. S. Remington. 1994. Production of γ interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha. Infect. Immun. 62:2818.
44. Gazzinelli, R. T., M. Wysocka, S. Hayashi, E. Y. Denkers, S. Hieny, P. Caspar, G. Trinchieri, and A. Sher. 1994. Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. J. Immunol. 153:2533.
45. Scharton-Kersten, T. M., T. A. Wynn, E. Y. Denkers, S. Bala, E. Grunvald, S. Hieny, R. T. Gazzinelli, and A. Sher. 1996. In the absence of endogenous IFN-γ, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J. Immunol. 157:4045.
46. - cells. J. Immunol. 160:4738.
47. Zhang, T., K. Kawakami, M. H. Qureshi, H. Okamura, M. Kurimoto, and A. Saito. 1997. Interleukin-12 and IL-18 synergistically induce the fungicidal activity of peritoneal exudate cells against Cryptococcus neoformans through production of y interferon by natural killer cells. Infect. Immun. 65:3594.
48. Hunter, C. A., J. Timans, P. Pisacane, S. Menon, G. Cai, R. Chizzonite, J. F. Bazan, and R. A. Kastelein. 1997. Comparison of the effects of interleukin-1α (IL-1α), IL-1β and interferon-γ-inducing factor on the production of interferon-γ by NK cells. Eur. J. Immunol. 27:2787.
49. Young, H. A. 1996. Regulation of interferon-γ gene expression. J. Interferon Cytokine Res. 16:563.
50. Sica, A., L. Dorman, V. Viggiano, M. Cippitelli, P. Ghosh, N. Rice, and H. A. Young. 1997. Interaction of NF-κB and NFAT with the interferon-promoter. J. Biol. Chem. 272:30412.
51. Scharton-Kersten, T. M., G. Yap, J. Magram, and A. Sher. 1997. Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. J. Exp. Med. 185:1261.
52. Suzuki, Y., M. A. Orelana, R. D. Schreiber, and J. S. Remington. 1988. Inteferon-γ: the major mediator of resistance against Toxoplasma gondii. Science 240:516.
53. DeKoning, J., L. DiMolfetto, C. Reilly, Q. Wei, W. L. Havran, and D. Lo. 1997. Thymic cortical epithelium is sufficient for the development of mature T cells in relB-deficient mice. J. Immunol. 158:2558.
54. Prieschl, E. E., G. G. Pendl, A. Elbe, E. Serfling, N. E. Harrer, G. Stingl, and T. Baumruker. 1996. Induction of the TNF-α promoter in the murine dendritic cell line 18 and the murine mast cell line CPII is differentially regulated. J. Immunol. 157:2645.
55. Beauparlant, P., and J. Hiscott. 1996. Biological and biochemical inhibitors of the NF-κB/Rel proteins and cytokine synthesis. Cytokine Growth Factor Rev. 7:175.
56. Yap, G. S., T. Scharton-Kersten, H. Charest, and A. Sher. 1998. Decreased resistance of TNF receptor p55- and p75-deficient mice to chronic toxoplasmosis despite normal activation of inducible nitric oxide synthase in vivo. J. Immunol. 160:1340.
57. Deckert-Schluter, M., H. Bluethmann, A. Rang, H. Hof, and D. Schluter. 1998. Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis. J. Immunol. 160:3427.
58. Chang, H. R., G. E. Grau, and J. C. Pechere. 1990. Role of TNF and IL-1 in infections with Toxoplasma gondii. Immunol. 69:33.
59. + T lymphocytes in early IFN-γ-dependent resistance to Toxoplasma gondii. J. Immunol. 160:2565.
60. Sabin, E. A., M. A. Kopf, and E. J. Pearce. 1996. Schistosoma mansoni egg-induced early IL-4 production is dependent upon IL-5 and eosinophils. J. Exp. Med. 184:1871.
61. Marone, G., V. Casolaro, V. Patella, G. Florio, and M. Triggiani. 1997. Molecular and cellular biology of mast cells and basophils. Int. Arch. Allergy Immunol. 114:207.
62. Frandji, P., W. Mourad, C. Tkaczyk, M. Singer, B. David, J. Colle, and S. Mecheri. 1998. IL-4 mRNA transcription is induced in mouse bone marrow-derived mast cells through an MHC class II-dependent signaling pathway. Eur. J. Immunol. 28:844.
63. Franzoso, G., L. Carlson. T. Scharton-Kersten, E. W. Shores, S. Epstein, A. Grinberg, T. Tran, E. Shacter, A. Leonardi, M. Anver, et al. 1997. Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic architecture, and germinal center reactions. Immunity 6:479.
64. Franzoso, G., L. Carlson, L. Poljak, E. W. Shores, S. Epstein, A. Leonardi, A. Grinberg, T. Tran, T. Scharton-Kersten, M. Anver, et al. 1998. Mice deficient in nuclear factor (NF)-κB/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture. J. Exp. Med. 187:147.