Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-κB1) but expressing p50

Journal of Experimental Medicine

Volumn 187, Issue 7, 1998, Pages 985-996

  Ishikawa, Hideaki ^a   Claudio, Estefania ^a   Dambach, Donna ^a   Raventós Suárez, Carmen ^a   Ryan, Carol ^a   Bravo, Rodrigo ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; POLYPEPTIDE; PROTEIN P105; PROTEIN P50; PROTEIN PRECURSOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; CARBOXY TERMINAL SEQUENCE; CHRONIC INFLAMMATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; EXTRAMEDULLARY HEMATOPOIESIS; LYMPH NODE HYPERPLASIA; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC INFILTRATION; LYMPHOID HYPERPLASIA; MOUSE; MOUSE MUTANT; NONHUMAN; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; SPLENOMEGALY;

ANIMALS; CYTOKINES; DIMERIZATION; FLOW CYTOMETRY; GENE TARGETING; HEMATOPOIESIS; IMMUNOGLOBULIN G; INFLAMMATION; LIVER; LUNG; LYMPH NODES; LYMPHOCYTES; MACROPHAGES; MICE; MICE, KNOCKOUT; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; OPPORTUNISTIC INFECTIONS; PROTEIN PRECURSORS; SPLEEN; THYMUS GLAND;

EID: 0032489828     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.7.985     Document Type: Article

References (54)

1. Grilli, M., J.-S. Chiu, and M.J. Lenardo. 1993. NF-κB and Rel-participants in a multiform transcriptional regulatory system. Int. Rev. Cytol. 143:1-62.
2. Baeuerle, P.A., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12: 141-179.
3. Kopp, E.B., and S. Ghosh. 1995. NF-κB and Rel proteins in innate immunity. Adv. Immunol. 58:1-27.
4. Miyamoto, S., and I.M. Verma. 1995. Rel/NF-κB/IκB story. Adv. Cancer Res. 66:255-292.
5. Beg, A.A., and A.S. Baldwin, Jr. 1993. The IκB proteins: multifunctional regulators of Rel/NF-κB transcription factors. Genes Dev. 7:2063-2070.
6. Gilmore, T.D., and P.J. Morin. 1993. The IκB proteins: members of a multifunctional family. Trends Genet. 9:427-433.
7. Liou, H.-C., and D. Baltimore. 1993. Regulation of the NF-κB/rel transcription factor and IκB inhibitor system. Curr. Opin. Cell Biol. 5:477-487.
8. Siebenlist, U., G. Franzoso, and K. Brown. 1994. Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10: 405-455.
9. Finco, T.S., and A.S. Baldwin. 1995. Mechanistic aspects of NF-κB regulation: the emerging role of phosphorylation and proteolysis. Immunity. 3:263-272.
10. Carrasco, D., R.-P. Ryseck, and R. Bravo. 1993. Expression of relB transcripts during lymphoid organ development: specific expression in dendritic antigen-presenting cells. Development. 118:1221-1231.
11. Carrasco, D., F. Weih, and R. Bravo. 1994. Developmental expression of the c-rel protooncogene in hematopoietic organs. Development. 120:2991-3004.
12. Weih, F., D. Carrasco, and R. Bravo. 1994. Constitutive and inducible Rel/NF-κB activities in mouse thymus and spleen. Oncogene. 9:3289-3297.
13. Beg, A.A., W.C. Sha, R.T. Bronson, S. Ghosh, and D. Baltimore. 1995. Embryonic lethality and liver degeneration in mice lacking the RelA components of NF-κB. Nature. 376: 167-170.
14. Burkly, L., C. Hesslon, L. Ogata, C. Reilly, L.A. Marconi, D. Olson, R. Tizard, R. Cate, and D. Lo. 1995. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature. 373:531-536.
15. Kontgen, F., R.J. Grumont, A. Strasser, D. Metcalf, R. Li, D. Tarlinton, and S. Gerondakis. 1995. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9:1965-1977.
16. Sha, W.C., H.-C. Liou, E.I. Tuomanen, and D. Baltimore. 1995. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell. 80:321-330.
17. Weih, F., D. Carrasco, S.K. Durham, D.S. Barton, C.A. Rizzo, R.-P. Ryseck, S.A. Lira, and R. Bravo. 1995. Multiorgan inflammation and hemopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/ Rel family. Cell. 80:331-340.
18. Thanos, D., and T. Maniatis. 1995. NF-κB: a lesson in family values. Cell. 80:529-532.
19. Verma, I.M., J.K. Stevenson, E.M. Schwarz, D. Van Antwerp, and S. Miyamoto. 1995. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9:2723-2735.
20. Whiteside, S.T., J.-C. Epinat, N.R. Rice, and A. Israël. 1997. I kappa B epsilon, a novel member of the IκB family, controls RelA and cRel NF-κB activity. EMBO (Eur. Mol. Biol. Organ.) J. 16:1413-1426.
21. Imbert, V., R.A. Rupec, A. Livolsi, H.L. Phal, E.B.-M. Traenckner, C. Mueller-Dieckmann, D. Farahifar, B. Rossi, P. Auberger, P.A. Baeuerle, and J.-F. Peyron. 1996. Tyrosine phosphorylation of IκB-α activates NF-κB without proteolytic degradation of IκB-α. Cell. 86:787-798.
22. Palombella, V.J., O.J. Rando, A.L. Goldberg, and T. Maniatis. 1994. The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell. 78:773-785.
23. Chen, Z.J., J. Hagler, V.J. Palombella, F. Melandri, D. Scherer, D. Ballard, and T. Maniatis. 1995. Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway. Genes Dev. 9:1586-1597.
24. Chen, Z.J., L. Parent, and T. Maniatis. 1996. Site-specific phosphorylation of IκBα by novel ubiquitmation-dependent protein kinase activity. Cell. 84:853-862.
25. Didonato, J.A., M. Hayakawa, D.M. Rothwarf, E. Zandi, and M. Karin. 1997. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature. 388:548-554.
26. Inoue, J.-I., L.D. Kerr, A. Kakizuka, and I.M. Verma. 1992. IκBγ, a 70 kd protein identical to the C-terminal half of p110 NF-κB: a new member of the IκB family. Cell. 68: 1109-1120.
27. Liou, H.-C., G.P. Nolan, S. Ghosh, T. Fujita, and D. Baltimore. 1992. The NF-κB p50 precursor, p105, contains an internal IκB-like inhibitor that preferentially inhibits p50. EMBO (Eur. Mol. Biol. Organ.) J. 11:3003-3009.
28. Ishikawa, H., R.-P. Ryseck, and R. Bravo. 1996. Characterization of ES cells deficient for the p105 precursor (NF-κB1): role of p50 NLS. Oncogene. 13:255-263.
29. Ishikawa, H., E. Claudio, D. Carrasco, R.-P. Ryseck, and R. Bravo. 1997. Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-κB2. J. Exp. Med. 186:999-1014.
30. Lernbecher, T., U. Muller, and T. Wirth. 1993. Distinct NF-κB/Rel transcription factors are responsible for tissue-specific and inducible gene activation. Nature. 365:767-770.
31. Coligan, J.E., A.M. Kruisbeek, D.H. Margulies, E.M. Schevach, and W. Strober. 1992. Isolation and fractionation of mononuclear cell populations. Current Protocols in Immunology. Greene Publishing Associates & Wiley-Interscience, New York.
32. Schreiber, E., P. Matthias, M.M. Muller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with "mini-extracts," prepared from a small number of cells. Nucleic Acids Res. 17:6419.
33. Claudio, E., F. Segade, K. Wrobel, S. Ramos, R. Bravo, and P.S. Lazo. 1996. Molecular mechanisms of TNFα cytotoxicity: activation of NF-κB and nuclear translocation. Exp. Cell Res. 224:63-71.
34. Dobrzanski, P., R.-P. Ryseck, and R. Bravo. 1994. Differential interactions of Rel/NF-κB complexes with IκBα determine pools of constitutive and inducible NF-κB activity, which differ in their composition. EMBO (Eur. Mol. Biol. Organ.) J. 13:4608-4616.
35. Carrasco, D., C.A. Rizzo, K. Dorfman, and R. Bravo. 1996. The v-rel oncogene promotes malignant T-cell leukemia/ lymphoma in trangenic mice. EMBO (Eur. Mol. Biol. Organ.) J. 15-3640-3650.
36. Matsumoto, M., S. Mariathasan, M.H. Nahm, F. Baranyay, J.J. Peschon, and D.D. Chaplin. 1996. Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science. 271:1289-1291.
37. Chase, M.W. 1967. Production of antiserum. Methods Immunol. Immunochem. 1:197-209.
38. Lalor, P.A., G.J.V. Nelson, R.D. Sanderson, and M.G. McHeyzer-Williams. 1992. Functional and molecular characterization of single, (4-hydroxy-3-nitrophenyl) acetyl (NP)-specific, IgG+ B cells from antibody-secreting and memory B cell pathways in the C57BL/6 immune response to NP. Eur. J. Immunol. 22:3001-3011.
39. Rice, N.R., M.L. MacKichan, and A. Israel 1992. The precursor of NF-κB p50 has IκB-like functions. Cell. 71:243-253.
40. Mercurio, F., J.A. DiDonato, C. Rosette, and M. Karin. 1993. p105 and p98 precursor proteins play an active role in NF-κB-mediated signal transduction. Genes Dev. 7:705-718.
41. Naumann, M., F.G. Wulczyn, and C. Scheidereit. 1993. The NF-κB precursor p105 and the proto-oncogene product Bcl-3 are IκB molecules and control nuclear translocation of NF-κB. EMBO (Eur. Mol. Biol. Organ.) J. 12:213-222.
42. Sun, S.-C., P.A. Ganchi, C. Beraud, D.W. Ballard, and W.C. Greene. 1994. Autoregulation of the NF-κB transactivator RelA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs. Proc. Natl. Acad. Sci. USA. 91:1346-1350.
43. H transcription, and Ig class switching. J. Immunol. 156:183-191.
44. Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A.C. Feller, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell. 75:253-261.
45. Dranoff, G., A.D. Crawford, M. Sadelain, B. Ream, A. Rashid, R. T. Bronson, G.R. Dickersin, C.J. Bachurski, E.L. Mark, J.A. Whitsett, and R.C. Mulligan. 1994. Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science. 264:713-716.
46. Bours, V., G. Franzoso, V. Azarenko, S. Park, T. Kanno, K. Brown, and U. Siebenlist. 1993. The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers. Cell. 72:729-739.
47. Fujita, T., G.P. Nolan, H.-C. Liou, M.L. Scott, and D. Baltimore. 1993. The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-κB p50 homodimers. Genes Dev. 7:1354-1363.
48. Schwarz, E.M., P. Krimpenfort, A. Berns, and I.M. Verma. 1997. Immunological defects in mice with a targeted disruption in Bcl-3. Genes Dev. 11:187-197.
49. Franzoso, G., L. Carlson, T. Scharton-Kersten, E.W. Shores, S. Epstein, A. Grinberg, T. Tran, E. Shacter, A. Leonardi, M. Anver, et al. 1997. Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture and germinal center reactions. Immunity. 6:479-490.
50. Perez, P., S.A. Lira, and R. Bravo. 1995. Overexpression of RelA in transgenic mouse thymocytes: specific increase in levels of the inhibitor protein IκBα. Mol. Cell. Biol. 15:3523-3530.
51. Klement, J.F., N.R. Rice, B.D. Car, S.J. Abondanzo, G.D. Powers, H. Bhatt, C.-H. Chen, C.A. Rosen, and C.L. Stewart. 1996. IκBα deficiency results in a sustained NF-κB response and severe widespread dermatitis in mice. Mol. Cell. Biol. 16:2341-2349.
52. Beg, A.A., W.C. Sha, R.T. Bronson, and D. Baltimore. 1995. Constitutive NF-κB activation, enhanced granulopoiesis, and neonatal lethality in IκBα-deficient mice. Genes Dev. 9:2736-2746.
53. Fujita, T., G.P. Nolan, S. Ghosh, and D. Baltimore. 1992. Independent modes of transcriptional activation by the p50 and p65 subunits of NF-κB. Genes Dev. 6:775-787.
54. Kretzschmar, M., M. Meisterernst, C. Scheidereit, G. Li, and R.G. Roeder. 1992. Transcriptional regulation of the HIV-1 promoter by NF-κB in vitro. Genes Dev. 6:761-774.