Emerging molecular targets in the treatment of bacterial meningitis

Expert Opinion on Therapeutic Targets

Volumn 7, Issue 2, 2003, Pages 141-152

  Kim, Kwang Sik ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bacteraemia; Blood brain barrier; Brain microvascular endothelial cells; Calcitonin gene related peptide; Caspases; Chemokines; CNS; Cytokines; Cytosolic phospholipase A2 (cPLA2); Cytotoxic necrotising factor 1 (CNF 1); E. coli K1; Endothelins; Excitatory amino acids; Focal adhesion kinase; gp96; Group B streptococcus; Ibe; Laminin receptor precursor; Listeria monocytogenes; Matrix metalloproteinases; Meningitis; Neisseria miningitidis NF B; OmpA; Peroxynitrite; Phosphatidylinositol 3 kinase (PI3K); Reactive nitrogen species; Reactive oxygen species; Rho GTPases; Streptococcus pneumoniae; Substance P; TNF converting enzyme

Indexed keywords

ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; BACTERIUM ANTIBODY; BATIMASTAT; BB 1101; CALCITONIN GENE RELATED PEPTIDE; CASPASE INHIBITOR; CYTOKINE ANTIBODY; ENDOTHELIN; EXCITATORY AMINO ACID; FUCOIDIN; GELATINASE B; HAEMOPHILUS INFLUENZAE TYPE B VACCINE; ILOMASTAT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; MATRIX METALLOPROTEINASE INHIBITOR; MENINGOCOCCUS VACCINE; PEROXYNITRITE; PNEUMOCOCCUS VACCINE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SCAVENGER; SEROTONIN AGONIST; STREPTOCOCCUS VACCINE; SUBSTANCE P; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANTIMICROBIAL THERAPY; APOPTOSIS; BACTERIAL MENINGITIS; BACTERIAL TRANSLOCATION; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN INJURY; BRAIN NECROSIS; DISEASE ASSOCIATION; DISEASE MARKER; DRUG FORMULATION; DRUG TARGETING; HIPPOCAMPUS; HOST PATHOGEN INTERACTION; IMMUNOGENICITY; INFLAMMATION; MORBIDITY; MORTALITY; NEUROLOGICAL COMPLICATION; NONHUMAN; PATHOGENESIS; REVIEW;

ADAM PROTEINS; ADULT; ANIMALS; ANTI-BACTERIAL AGENTS; BACTEREMIA; BACTERIAL VACCINES; BLOOD-BRAIN BARRIER; CASPASES; CHEMOTAXIS, LEUKOCYTE; CHILD; CHILD, PRESCHOOL; DRUG DESIGN; ENDOTHELIUM, VASCULAR; EXCITATORY AMINO ACIDS; HUMANS; IMMUNIZATION, PASSIVE; INFANT; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MATRIX METALLOPROTEINASE 9; MENINGITIS, BACTERIAL; NEURONS; NF-KAPPA B; PROTEASE INHIBITORS; RABBITS; RATS; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

EID: 0037396915     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.7.2.141     Document Type: Review

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