Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: Association with blood-brain barrier damage and neurological sequelae

Clinical Infectious Diseases

Volumn 31, Issue 1, 2000, Pages 80-84

  Leppert, D ^a   Leib, S L ^b   Grygar, C ^a   Miller, K M ^c   Schaad, U B ^a   Hollander G A ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c British Biotech Pharmaceuticals Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GELATINASE A; GELATINASE B; NEUTROPHIL COLLAGENASE; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BACTERIAL MENINGITIS; BLOOD BRAIN BARRIER; CEREBROSPINAL FLUID ANALYSIS; CEREBROSPINAL FLUID CYTOLOGY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPILEPSY; GRANULOCYTE; HEARING IMPAIRMENT; HUMAN; LUMBAR PUNCTURE; MENINX; NEUROLOGICAL COMPLICATION; PARENCHYMA; PRESCHOOL CHILD; PRIORITY JOURNAL; RISK FACTOR;

BLOOD-BRAIN BARRIER; BRAIN DAMAGE, CHRONIC; CHILD; CHILD, PRESCHOOL; FOLLOW-UP STUDIES; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HUMANS; INFANT; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 8; MATRIX METALLOPROTEINASE 9; MENINGITIS, BACTERIAL; MENINGITIS, MENINGOCOCCAL; MENINGITIS, PNEUMOCOCCAL; NEISSERIA MENINGITIDIS; RETROSPECTIVE STUDIES; SPINAL PUNCTURE; STREPTOCOCCUS PNEUMONIAE; TIME FACTORS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034455606     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/313922     Document Type: Article

References (34)

1. Long-term sequelae of pneumococcal meningitis in children
2. Drug therapy: Treatment of bacterial meningitis
3. Brain injury in bacterial meningitis: Therapeutic implications
4. Neuronal injury in meningitis
5. Proteolytic remodeling of extracellular matrix
6. Matrix metalloproteinases and diseases of CNS
7. Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis
8. TIMP-2 reduces proteolytic opening of blood-brain barrier by type IV collagenase
9. Reversal of autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteinases
10. A combined inhibitor of matrix metalloproteinase activity and tumour necrosis factor-α processing attenuates experimental autoimmune neuritis
11. Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS
12. Gelatinase B modulates selective opening of the blood-brain barrier during inflammation
13. A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 8 (neutrophil collagenase) using monoclonal antibodies
14. Tumor necrosis factor in mediating experimental Haemophilus influenzae type B meningitis
15. rTNF alpha facilitates human polymorphonuclear leukocyte adherence to fibrinogen matrices with mobilization of specific and tertiary but not azurophilic granule markers
16. Tumor necrosis factor-α-induced gelatinase B causes delayed opening of the blood-brain barrier: An expanded therapeutic window
17. TNF-α and IL-1β selectively induce expression of 92-kDa gelatinase by human macrophages
18. Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells: Regulation by tumor necrosis factor-α and doxycycline
19. Cytokine and chemokine regulation of proMMP-9 and TIMP-1 production by human peripheral blood lymphocytes
20. Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders
21. A comparison of ceftriaxone and cefuroxime for the treatment of bacterial meningitis in children
22. Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis: Relation to blood-brain barrier injury
23. Matrix metalloproteinase-9 (gelatinase B) is selectively elevated in CSF during relapses and stable phases of multiple sclerosis
24. Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci
25. Cerebrospinal fluid interleukin 1-β and tumor necrosis factor concentrations and outcome from neonatal gram-negative enteric bacillary meningitis
26. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in viral meningitis: Up-regulation of MMP-9 and TIMP-1 in cerebrospinal fluid
27. Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis
28. Local production of tumor necrosis factor-α, interleukin-1 and interleukin-6 in meningococcal meningitis
29. Combined inhibition of tumor necrosis factor-α converting enzyme and matrix metalloproteinases by BB1101 attenuates disease, mortality and brain damage in experimental bacterial meningitis
30. Dexamethasone as adjunctive therapy in bacterial meningitis: A meta-analysis of randomized clinical trials since 1988
31. Anti-inflammatory treatment influences neuronal apoptotic cell death in the dentate gyrus in experimental pneumococcal meningitis
32. Dexamethasone and bacterial meningitis in Pakistan
33. Modulation of inflammation and cachectin activity in relation to treatment of experimental Haemophilus influenzae type b meningitis
34. T cell gelatinases mediate basement membrane transmigration in vitro