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Volumn 62, Issue 4, 2003, Pages 340-350

Neurotrophins and neurodegenerative diseases: Receptors stuck in traffic?

Author keywords

Alzheimer disease; BDNF; Huntington disease; Neurotrophins; NGF; Parkinson disease; Trafficking

Indexed keywords

NEUROTROPHIC FACTOR; NEUROTROPHIN; NEUROTROPHIN RECEPTOR;

EID: 0037384814     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/62.4.340     Document Type: Review
Times cited : (36)

References (97)
  • 1
    • 0034927081 scopus 로고    scopus 로고
    • Neurotrophins: Roles in neuronal development and function
    • Huang EJ, Reichardt LF. Neurotrophins: Roles in neuronal development and function. Annu Rev Neurosci 2001;24:677-36
    • (2001) Annu Rev Neurosci , vol.24 , pp. 677-736
    • Huang, E.J.1    Reichardt, L.F.2
  • 2
    • 0036344505 scopus 로고    scopus 로고
    • Neurotrophin signaling through the p75 neurotrophin receptor
    • Roux PP, Barker PA. Neurotrophin signaling through the p75 neurotrophin receptor. Prog Neurobiol 2002;67:203-33
    • (2002) Prog Neurobiol , vol.67 , pp. 203-233
    • Roux, P.P.1    Barker, P.A.2
  • 3
    • 0026787533 scopus 로고
    • Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons
    • Schecterson LC, Bothwell M. Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons. Neuron 1992;9:449-63
    • (1992) Neuron , vol.9 , pp. 449-463
    • Schecterson, L.C.1    Bothwell, M.2
  • 4
    • 0029925683 scopus 로고    scopus 로고
    • Intracellular signaling pathways activated by neurotrophic factors
    • Segal RA, Greenberg ME. Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci 1996;19:463-89
    • (1996) Annu Rev Neurosci , vol.19 , pp. 463-489
    • Segal, R.A.1    Greenberg, M.E.2
  • 5
  • 6
    • 0033613422 scopus 로고    scopus 로고
    • Neurotrophin-evoked rapid excitation through TrkB receptors
    • Kafitz KW, Rose CR, Thoenen H, Konnerth A. Neurotrophin-evoked rapid excitation through TrkB receptors. Nature 1999;401: 918-21
    • (1999) Nature , vol.401 , pp. 918-921
    • Kafitz, K.W.1    Rose, C.R.2    Thoenen, H.3    Konnerth, A.4
  • 7
    • 0030856172 scopus 로고    scopus 로고
    • CREB: A major mediator of neuronal neurotrophin responses
    • Finkbeiner S, Tavazoie SF, Maloratsky A, et al. CREB: A major mediator of neuronal neurotrophin responses. Neuron 1997;19: 1031-47
    • (1997) Neuron , vol.19 , pp. 1031-1047
    • Finkbeiner, S.1    Tavazoie, S.F.2    Maloratsky, A.3
  • 8
    • 0036047004 scopus 로고    scopus 로고
    • Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease
    • Terwel D, Dewachter L, Van Leuven F. Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease. Neuromolecular Med 2002;2:151-65
    • (2002) Neuromolecular Med , vol.2 , pp. 151-165
    • Terwel, D.1    Dewachter, L.2    Van Leuven, F.3
  • 9
    • 0029366767 scopus 로고
    • A role for neurofilaments in the pathogenesis of amyotrophic lateral sclerosis
    • Julien JP. A role for neurofilaments in the pathogenesis of amyotrophic lateral sclerosis. Biochem Cell Biol 1995;73:593-97
    • (1995) Biochem Cell Biol , vol.73 , pp. 593-597
    • Julien, J.P.1
  • 10
    • 0019781601 scopus 로고
    • A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and Alzheimer disease
    • Appel SH. A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and Alzheimer disease. Ann Neurol 1981;10:499-505
    • (1981) Ann Neurol , vol.10 , pp. 499-505
    • Appel, S.H.1
  • 11
    • 0020913197 scopus 로고
    • Neuronotrophic and neurite-promoting factors and their clinical potentials
    • Varon S, Manthorpe M, Williams LR. Neuronotrophic and neurite-promoting factors and their clinical potentials. Dev Neurosci 1983; 6:73-100
    • (1983) Dev Neurosci , vol.6 , pp. 73-100
    • Varon, S.1    Manthorpe, M.2    Williams, L.R.3
  • 12
    • 0029910952 scopus 로고    scopus 로고
    • Programmed cell death in the developing nervous system
    • Burek MJ, Oppenheim RW. Programmed cell death in the developing nervous system. Brain Pathol 1996;6:427-46
    • (1996) Brain Pathol , vol.6 , pp. 427-446
    • Burek, M.J.1    Oppenheim, R.W.2
  • 13
    • 0033635904 scopus 로고    scopus 로고
    • Neurotrophins: Key regulators of cell fate and cell shape in the vertebrate nervous system
    • Bibel M, Barde YA. Neurotrophins: Key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev 2000;14: 2919-37
    • (2000) Genes Dev , vol.14 , pp. 2919-2937
    • Bibel, M.1    Barde, Y.A.2
  • 14
    • 0028238769 scopus 로고
    • Functions of the neurotrophins during nervous system development: What the knockouts are teaching us
    • Snider WD. Functions of the neurotrophins during nervous system development: What the knockouts are teaching us. Cell 1994;77: 627-38
    • (1994) Cell , vol.77 , pp. 627-638
    • Snider, W.D.1
  • 15
    • 0034641936 scopus 로고    scopus 로고
    • Apoptosis in the nervous system
    • Yuan J, Yankner BA. Apoptosis in the nervous system. Nature 2000;407:802-9
    • (2000) Nature , vol.407 , pp. 802-809
    • Yuan, J.1    Yankner, B.A.2
  • 16
    • 0033710349 scopus 로고    scopus 로고
    • Cortical degeneration in the absence of neurotrophin signaling: Dendritic retraction and neuronal loss after removal of the receptor TrkB
    • Xu B, Zang K, Ruff NL, et al. Cortical degeneration in the absence of neurotrophin signaling: Dendritic retraction and neuronal loss after removal of the receptor TrkB. Neuron 2000;26:233-45
    • (2000) Neuron , vol.26 , pp. 233-245
    • Xu, B.1    Zang, K.2    Ruff, N.L.3
  • 17
    • 0025452844 scopus 로고
    • Nerve growth factor regulates sympathetic ganglion cell morphology and survival in the adult mouse
    • Ruit KG, Osborne PA, Schmidt RE, Johnson EM, Jr, Snider WD. Nerve growth factor regulates sympathetic ganglion cell morphology and survival in the adult mouse. J Neurosci 1990;10:2412-19
    • (1990) J Neurosci , vol.10 , pp. 2412-2419
    • Ruit, K.G.1    Osborne, P.A.2    Schmidt, R.E.3    Johnson E.M., Jr.4    Snider, W.D.5
  • 18
    • 85047700298 scopus 로고    scopus 로고
    • Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease
    • Ventriglia M, Bocchio Chiavetto L, Benussi L, et al. Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease. Mol Psychiatry 2002;7:136-37
    • (2002) Mol Psychiatry , vol.7 , pp. 136-137
    • Ventriglia, M.1    Bocchio Chiavetto, L.2    Benussi, L.3
  • 19
    • 0035134990 scopus 로고    scopus 로고
    • A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease
    • Kunugi H, Ueki A, Otsuka M, et al. A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease. Mol Psychiatry 2001;6:83-86
    • (2001) Mol Psychiatry , vol.6 , pp. 83-86
    • Kunugi, H.1    Ueki, A.2    Otsuka, M.3
  • 20
    • 0036135090 scopus 로고    scopus 로고
    • Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms
    • Momose Y, Murata M, Kobayashi K, et al. Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms. Ann Neurol 2002;51:133-36
    • (2002) Ann Neurol , vol.51 , pp. 133-136
    • Momose, Y.1    Murata, M.2    Kobayashi, K.3
  • 21
    • 0036235860 scopus 로고    scopus 로고
    • Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: Potential impact of CNTF as a candidate modifier gene
    • Giess R, Holtmann B, Braga M, et al. Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: Potential impact of CNTF as a candidate modifier gene. Am J Hum Genet 2002; 70:1277-86
    • (2002) Am J Hum Genet , vol.70 , pp. 1277-1286
    • Giess, R.1    Holtmann, B.2    Braga, M.3
  • 22
    • 0033813571 scopus 로고    scopus 로고
    • Neurotrophic factors in Alzheimer's and Parkinson's disease brain
    • Siegel GJ, Chauhan NB. Neurotrophic factors in Alzheimer's and Parkinson's disease brain. Brain Res Brain Res Rev 2000;33: 199-227
    • (2000) Brain Res Brain Res Rev , vol.33 , pp. 199-227
    • Siegel, G.J.1    Chauhan, N.B.2
  • 23
    • 0035239020 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
    • Murer MG, Yan Q, Raisman-Vozari R. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Prog Neurobiol 2001;63:71-124
    • (2001) Prog Neurobiol , vol.63 , pp. 71-124
    • Murer, M.G.1    Yan, Q.2    Raisman-Vozari, R.3
  • 24
  • 25
    • 0032904490 scopus 로고    scopus 로고
    • Distribution and retrograde transport of trophic factors in the central nervous system: Functional implications for the treatment of neurodegenerative diseases
    • Mufson EJ, Kroin JS, Sendera TJ, Sobreviela T. Distribution and retrograde transport of trophic factors in the central nervous system: Functional implications for the treatment of neurodegenerative diseases. Prog Neurobiol 1999;57:451-84
    • (1999) Prog Neurobiol , vol.57 , pp. 451-484
    • Mufson, E.J.1    Kroin, J.S.2    Sendera, T.J.3    Sobreviela, T.4
  • 26
    • 0032563565 scopus 로고    scopus 로고
    • Medial nigral dopamine neurons have rich neurotrophin support in humans
    • Nishio T, Furukawa S, Akiguchi I, Sunohara N. Medial nigral dopamine neurons have rich neurotrophin support in humans. Neuroreport 1998;9:2847-51
    • (1998) Neuroreport , vol.9 , pp. 2847-2851
    • Nishio, T.1    Furukawa, S.2    Akiguchi, I.3    Sunohara, N.4
  • 27
    • 0032507658 scopus 로고    scopus 로고
    • Neutrophin switching in spinal motoneurons of amyotrophic lateral sclerosis
    • Nishio T, Sunohara N, Furukawa S. Neutrophin switching in spinal motoneurons of amyotrophic lateral sclerosis. Neuroreport 1998;9: 1661-65
    • (1998) Neuroreport , vol.9 , pp. 1661-1665
    • Nishio, T.1    Sunohara, N.2    Furukawa, S.3
  • 28
    • 0034848604 scopus 로고    scopus 로고
    • The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease
    • Fahnestock M, Michalski B, Xu B, Coughlin MD. The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease. Mol Cell Neurosci 2001;18:210-20
    • (2001) Mol Cell Neurosci , vol.18 , pp. 210-220
    • Fahnestock, M.1    Michalski, B.2    Xu, B.3    Coughlin, M.D.4
  • 29
    • 0034728595 scopus 로고    scopus 로고
    • Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: Decreased levels in Alzheimer's disease
    • Holsinger RM, Schnarr J, Henry P, Castelo VT, Fahnestock M. Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: Decreased levels in Alzheimer's disease. Brain Res Mol Brain Res 2000;76: 347-54
    • (2000) Brain Res Mol Brain Res , vol.76 , pp. 347-354
    • Holsinger, R.M.1    Schnarr, J.2    Henry, P.3    Castelo, V.T.4    Fahnestock, M.5
  • 30
    • 0032805204 scopus 로고    scopus 로고
    • BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies
    • Ferrer I, Marin C, Rey MJ, et al. BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies. J Neuropathol Exp Neurol 1999;58:729-39
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 729-739
    • Ferrer, I.1    Marin, C.2    Rey, M.J.3
  • 31
    • 0033517723 scopus 로고    scopus 로고
    • Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease
    • Allen SJ, Wilcock GK, Dawbarn D. Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease. Biochem Biophys Res Commun 1999;264:648-51
    • (1999) Biochem Biophys Res Commun , vol.264 , pp. 648-651
    • Allen, S.J.1    Wilcock, G.K.2    Dawbarn, D.3
  • 32
    • 0034520301 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and neurotrophin-3 levels in Alzheimer's disease brains
    • Durany N, Michel T, Kurt J, et al. Brain-derived neurotrophic factor and neurotrophin-3 levels in Alzheimer's disease brains. Int J Dev Neurosci 2000;18:807-13
    • (2000) Int J Dev Neurosci , vol.18 , pp. 807-813
    • Durany, N.1    Michel, T.2    Kurt, J.3
  • 33
    • 0034054499 scopus 로고    scopus 로고
    • P75 neurotrophin receptor in the nucleus basalis of meynert in relation to age, sex, and Alzheimer's disease
    • Salehi A, Ocampo M, Verhaagen J, Swaab DF. P75 neurotrophin receptor in the nucleus basalis of meynert in relation to age, sex, and Alzheimer's disease. Exp Neurol 2000;161:245-58
    • (2000) Exp Neurol , vol.161 , pp. 245-258
    • Salehi, A.1    Ocampo, M.2    Verhaagen, J.3    Swaab, D.F.4
  • 34
    • 0031695632 scopus 로고    scopus 로고
    • TrkA immunoreactivity in reactive astrocytes in human neurodegenerative diseases and colchicine-treated rats
    • Aguado F, Ballabriga J, Pozas E, Ferrer I. TrkA immunoreactivity in reactive astrocytes in human neurodegenerative diseases and colchicine-treated rats. Acta Neuropathol (Berl) 1998;96:495-501
    • (1998) Acta Neuropathol (Berl) , vol.96 , pp. 495-501
    • Aguado, F.1    Ballabriga, J.2    Pozas, E.3    Ferrer, I.4
  • 35
    • 0032846365 scopus 로고    scopus 로고
    • Absence of brain-derived neurotrophic factor and trkB receptor immunoreactivity in glia of Alzheimer's disease
    • Soontornniyomkij V, Wang G, Pittman CA, et al. Absence of brain-derived neurotrophic factor and trkB receptor immunoreactivity in glia of Alzheimer's disease. Acta Neuropathol (Berl) 1999;98: 345-48
    • (1999) Acta Neuropathol (Berl) , vol.98 , pp. 345-348
    • Soontornniyomkij, V.1    Wang, G.2    Pittman, C.A.3
  • 36
    • 0000429264 scopus 로고    scopus 로고
    • Neurotrophin trafficking by anterograde transport
    • Altar CA, DiStefano PS. Neurotrophin trafficking by anterograde transport. Trends Neurosci 1998;21:433-37
    • (1998) Trends Neurosci , vol.21 , pp. 433-437
    • Altar, C.A.1    DiStefano, P.S.2
  • 37
    • 0031148557 scopus 로고    scopus 로고
    • Neurotrophin-3-like immunoreactivity and Trk C expression in human spinal motoneurones in amyotrophic lateral sclerosis
    • Duberley RM, Johnson IP, Anand P, Leigh PN, Cairns NJ. Neurotrophin-3-like immunoreactivity and Trk C expression in human spinal motoneurones in amyotrophic lateral sclerosis. J Neurol Sci 1997;148:33-40
    • (1997) J Neurol Sci , vol.148 , pp. 33-40
    • Duberley, R.M.1    Johnson, I.P.2    Anand, P.3    Leigh, P.N.4    Cairns, N.J.5
  • 38
    • 0034040626 scopus 로고    scopus 로고
    • Decreased phosphorylation levels of TrkB neurotrophin receptor in the spinal cords from patients with amyotrophic lateral sclerosis
    • Mutoh T, Sobue G, Hamano T, et al. Decreased phosphorylation levels of TrkB neurotrophin receptor in the spinal cords from patients with amyotrophic lateral sclerosis. Neurochem Res 2000;25: 239-45
    • (2000) Neurochem Res , vol.25 , pp. 239-245
    • Mutoh, T.1    Sobue, G.2    Hamano, T.3
  • 39
    • 0036434641 scopus 로고    scopus 로고
    • Elevated levels of neurotrophins in human biceps brachii tissue of amyotrophic lateral sclerosis
    • Kust BM, Copray JC, Brouwer N, Troost D, Boddeke HW. Elevated levels of neurotrophins in human biceps brachii tissue of amyotrophic lateral sclerosis. Exp Neurol 2002;177:419-27
    • (2002) Exp Neurol , vol.177 , pp. 419-427
    • Kust, B.M.1    Copray, J.C.2    Brouwer, N.3    Troost, D.4    Boddeke, H.W.5
  • 41
    • 0035490884 scopus 로고    scopus 로고
    • The endocytic pathway: A mosaic of domains
    • Gruenberg J. The endocytic pathway: A mosaic of domains. Nat Rev Mol Cell Biol 2001;2:721-30
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 721-730
    • Gruenberg, J.1
  • 42
    • 12544250585 scopus 로고    scopus 로고
    • Multivesicular bodies and multivesicular endosomes: The "ins and outs" of endosomal traffic
    • Stahl PD, Barbieri MA. Multivesicular bodies and multivesicular endosomes: The "ins and outs" of endosomal traffic. Sci STKE 2002;2002:PE32
    • (2002) Sci STKE , vol.2002
    • Stahl, P.D.1    Barbieri, M.A.2
  • 43
    • 0026779475 scopus 로고
    • Axonal and dendritic endocytic pathways in cultured neurons
    • Parton RG, Simons K, Dotti CG. Axonal and dendritic endocytic pathways in cultured neurons. J Cell Biol 1992;119:123-37
    • (1992) J Cell Biol , vol.119 , pp. 123-137
    • Parton, R.G.1    Simons, K.2    Dotti, C.G.3
  • 44
    • 0026058318 scopus 로고
    • Cell death during development of the nervous system
    • Oppenheim RW. Cell death during development of the nervous system. Annu Rev Neurosci 1991;14:453-501
    • (1991) Annu Rev Neurosci , vol.14 , pp. 453-501
    • Oppenheim, R.W.1
  • 45
    • 0030438511 scopus 로고    scopus 로고
    • A signaling endosome hypothesis to explain NGF actions: Potential implications for neurodegeneration
    • Beattie EC, Zhou J, Grimes ML, et al. A signaling endosome hypothesis to explain NGF actions: Potential implications for neurodegeneration. Cold Spring Harb Symp Quant Biol 1996;61: 389-406
    • (1996) Cold Spring Harb Symp Quant Biol , vol.61 , pp. 389-406
    • Beattie, E.C.1    Zhou, J.2    Grimes, M.L.3
  • 46
    • 0036671073 scopus 로고    scopus 로고
    • All signaling is local?
    • Schlessinger J. All signaling is local? Mol Cell 2002;10:218-19
    • (2002) Mol Cell , vol.10 , pp. 218-219
    • Schlessinger, J.1
  • 47
    • 0037154885 scopus 로고    scopus 로고
    • Retrograde support of neuronal survival without retrograde transport of nerve growth factor
    • MacInnis BL, Campenot RB. Retrograde support of neuronal survival without retrograde transport of nerve growth factor. Science 2002;295:1536-39
    • (2002) Science , vol.295 , pp. 1536-1539
    • MacInnis, B.L.1    Campenot, R.B.2
  • 48
    • 0030903317 scopus 로고    scopus 로고
    • Retroactive motors
    • Schnapp BJ. Retroactive motors. Neuron 1997;18:523-26
    • (1997) Neuron , vol.18 , pp. 523-526
    • Schnapp, B.J.1
  • 49
    • 0034433525 scopus 로고    scopus 로고
    • One axon, many kinesins: What's the logic?
    • Muresan V. One axon, many kinesins: What's the logic? J Neurocytol 2000;29:799-818
    • (2000) J Neurocytol , vol.29 , pp. 799-818
    • Muresan, V.1
  • 50
    • 0037096094 scopus 로고    scopus 로고
    • High-resolution imaging demonstrates dynein-based vesicular transport of activated Trk receptors
    • Bhattacharyya A, Watson FL, Pomeroy SL, et al. High-resolution imaging demonstrates dynein-based vesicular transport of activated Trk receptors. J Neurobiol 2002;51:302-12
    • (2002) J Neurobiol , vol.51 , pp. 302-312
    • Bhattacharyya, A.1    Watson, F.L.2    Pomeroy, S.L.3
  • 51
    • 0030985451 scopus 로고    scopus 로고
    • A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA
    • Grimes ML, Beattie E, Mobley WC. A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA. Proc Natl Acad Sci U S A 1997;94:9909-14
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 9909-9914
    • Grimes, M.L.1    Beattie, E.2    Mobley, W.C.3
  • 52
    • 10544248585 scopus 로고    scopus 로고
    • Endocytosis of activated TrkA: Evidence that nerve growth factor induces formation of signaling endosomes
    • Grimes ML, Zhou J, Beattie EC, et al. Endocytosis of activated TrkA: Evidence that nerve growth factor induces formation of signaling endosomes. J Neurosci 1996;16:7950-64
    • (1996) J Neurosci , vol.16 , pp. 7950-7964
    • Grimes, M.L.1    Zhou, J.2    Beattie, E.C.3
  • 53
    • 0035819073 scopus 로고    scopus 로고
    • NGF signaling from clathrin-coated vesicles: Evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway
    • Howe CL, Valletta JS, Rusnak AS, Mobley WC. NGF signaling from clathrin-coated vesicles: Evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway. Neuron 2001;32: 801-14
    • (2001) Neuron , vol.32 , pp. 801-814
    • Howe, C.L.1    Valletta, J.S.2    Rusnak, A.S.3    Mobley, W.C.4
  • 54
    • 0035256647 scopus 로고    scopus 로고
    • Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor
    • Yano H, Lee FS, Kong H, et al. Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor. J Neurosci 2001;21:RC125
    • (2001) J Neurosci , vol.21
    • Yano, H.1    Lee, F.S.2    Kong, H.3
  • 55
    • 0033568881 scopus 로고    scopus 로고
    • Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex
    • Watson FL, Heerssen HM, Moheban DB, et al. Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex. J Neurosci 1999;19:7889-7900
    • (1999) J Neurosci , vol.19 , pp. 7889-7900
    • Watson, F.L.1    Heerssen, H.M.2    Moheban, D.B.3
  • 56
    • 0033216248 scopus 로고    scopus 로고
    • Characterization of an NGF-P-TrkA retrograde-signaling complex and age-dependent regulation of TrkA phosphorylation in sympathetic neurons
    • Tsui-Pierchala BA, Ginty DD. Characterization of an NGF-P-TrkA retrograde-signaling complex and age-dependent regulation of TrkA phosphorylation in sympathetic neurons. J Neurosci 1999;19: 8207-18
    • (1999) J Neurosci , vol.19 , pp. 8207-8218
    • Tsui-Pierchala, B.A.1    Ginty, D.D.2
  • 57
    • 0034864339 scopus 로고    scopus 로고
    • Receptor binding, internalization, and retrograde transport of neurotrophic factors
    • Neet KE, Campenot RB. Receptor binding, internalization, and retrograde transport of neurotrophic factors. Cell Mol Life Sci 2001; 58:1021-35
    • (2001) Cell Mol Life Sci , vol.58 , pp. 1021-1035
    • Neet, K.E.1    Campenot, R.B.2
  • 58
    • 0034711405 scopus 로고    scopus 로고
    • Quantitative imaging of lateral ErbB1 receptor signal propagation in the plasma membrane
    • Verveer PJ, Wouters FS, Reynolds AR, Bastiaens PI. Quantitative imaging of lateral ErbB1 receptor signal propagation in the plasma membrane. Science 2000;290:1567-1570
    • (2000) Science , vol.290 , pp. 1567-1570
    • Verveer, P.J.1    Wouters, F.S.2    Reynolds, A.R.3    Bastiaens, P.I.4
  • 59
    • 0035824391 scopus 로고    scopus 로고
    • Gamma-secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase
    • Ni CY, Murphy MP, Golde TE, Carpenter G. gamma-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 2001;294:2179-81
    • (2001) Science , vol.294 , pp. 2179-2181
    • Ni, C.Y.1    Murphy, M.P.2    Golde, T.E.3    Carpenter, G.4
  • 60
    • 0037122878 scopus 로고    scopus 로고
    • NGF utilizes c-Ret via a novel GFL-independent, inter-RTK signaling mechanism to maintain the trophic status of mature sympathetic neurons
    • Tsui-Pierchala BA, Milbrandt J, Johnson EM, Jr. NGF utilizes c-Ret via a novel GFL-independent, inter-RTK signaling mechanism to maintain the trophic status of mature sympathetic neurons. Neuron 2002;33:261-73
    • (2002) Neuron , vol.33 , pp. 261-273
    • Tsui-Pierchala, B.A.1    Milbrandt, J.2    Johnson E.M., Jr.3
  • 61
    • 0034255428 scopus 로고    scopus 로고
    • Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation
    • Zhang Y, Moheban DB, Conway BR, Bhattacharyya A, Segal RA. Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation. J Neurosci 2000;20:5671-78
    • (2000) J Neurosci , vol.20 , pp. 5671-5678
    • Zhang, Y.1    Moheban, D.B.2    Conway, B.R.3    Bhattacharyya, A.4    Segal, R.A.5
  • 62
    • 0035836635 scopus 로고    scopus 로고
    • Cessation of rapid late endosomal tubulovesicular trafficking in Niemann-Pick type C1 disease
    • Zhang M, Dwyer NK, Love DC, et al. Cessation of rapid late endosomal tubulovesicular trafficking in Niemann-Pick type C1 disease. Proc Natl Acad Sci U S A 2001;98:4466-71
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 4466-4471
    • Zhang, M.1    Dwyer, N.K.2    Love, D.C.3
  • 63
    • 0034733750 scopus 로고    scopus 로고
    • Embryonic striatal neurons from niemann-pick type C mice exhibit defects in cholesterol metabolism and neurotrophin responsiveness
    • Henderson LP, Lin L, Prasad A, et al. Embryonic striatal neurons from niemann-pick type C mice exhibit defects in cholesterol metabolism and neurotrophin responsiveness. J Biol Chem 2000;275: 20179-87
    • (2000) J Biol Chem , vol.275 , pp. 20179-20187
    • Henderson, L.P.1    Lin, L.2    Prasad, A.3
  • 64
    • 0031867231 scopus 로고    scopus 로고
    • Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways
    • Velier J, Kim M, Schwarz C, et al. Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways. Exp Neurol 1998;152:34-40
    • (1998) Exp Neurol , vol.152 , pp. 34-40
    • Velier, J.1    Kim, M.2    Schwarz, C.3
  • 65
    • 0037155198 scopus 로고    scopus 로고
    • Expression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cells
    • Song C, Perides G, Liu YF. Expression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cells. J Biol Chem 2002;277: 6703-7
    • (2002) J Biol Chem , vol.277 , pp. 6703-6707
    • Song, C.1    Perides, G.2    Liu, Y.F.3
  • 66
    • 0037008677 scopus 로고    scopus 로고
    • Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking
    • Li Y, Chin LS, Levey AI, Li L. Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking. J Biol Chem 2002; 277:28212-21
    • (2002) J Biol Chem , vol.277 , pp. 28212-28221
    • Li, Y.1    Chin, L.S.2    Levey, A.I.3    Li, L.4
  • 67
    • 0036850524 scopus 로고    scopus 로고
    • HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis
    • Singaraja RR, Hadano S, Metzler M, et al. HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. Hum Mol Genet 2002;11:2815-28
    • (2002) Hum Mol Genet , vol.11 , pp. 2815-2828
    • Singaraja, R.R.1    Hadano, S.2    Metzler, M.3
  • 69
    • 0035031779 scopus 로고    scopus 로고
    • Polyglutamine and CBP: Fatal attraction?
    • McCampbell A, Fischbeck KH. Polyglutamine and CBP: Fatal attraction? Nat Med 2001;7:528-30
    • (2001) Nat Med , vol.7 , pp. 528-530
    • McCampbell, A.1    Fischbeck, K.H.2
  • 70
    • 0034700158 scopus 로고    scopus 로고
    • Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
    • Zhang Y, Gao J, Chung KK, et al. Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proc Natl Acad Sci U S A 2000;97:13354-59
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 13354-13359
    • Zhang, Y.1    Gao, J.2    Chung, K.K.3
  • 71
    • 0034834665 scopus 로고    scopus 로고
    • E3 ubiquitin-protein ligase activity of Parkin is dependent on cooperative interaction of RING finger (TRIAD) elements
    • Rankin CA, Joazeiro CA, Floor E, Hunter T. E3 ubiquitin-protein ligase activity of Parkin is dependent on cooperative interaction of RING finger (TRIAD) elements. J Biomed Sci 2001;8:421-29
    • (2001) J Biomed Sci , vol.8 , pp. 421-429
    • Rankin, C.A.1    Joazeiro, C.A.2    Floor, E.3    Hunter, T.4
  • 72
    • 0032190090 scopus 로고    scopus 로고
    • The ubiquitin pathway in Parkinson's disease
    • Leroy E, Boyer R, Auburger G, et al. The ubiquitin pathway in Parkinson's disease. Nature 1998;395:451-52
    • (1998) Nature , vol.395 , pp. 451-452
    • Leroy, E.1    Boyer, R.2    Auburger, G.3
  • 73
    • 0037077040 scopus 로고    scopus 로고
    • Toxic proteins in neurodegenerative disease
    • Taylor JP, Hardy J, Fischbeck KH. Toxic proteins in neurodegenerative disease. Science 2002;296:1991-95
    • (2002) Science , vol.296 , pp. 1991-1995
    • Taylor, J.P.1    Hardy, J.2    Fischbeck, K.H.3
  • 74
    • 0037031318 scopus 로고    scopus 로고
    • Membrane transport: A coat for ubiquitin
    • Clague MJ. Membrane transport: A coat for ubiquitin. Curr Biol 2002;12:R529-31
    • (2002) Curr Biol , vol.12
    • Clague, M.J.1
  • 75
    • 0035911147 scopus 로고    scopus 로고
    • A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment
    • Wunderlich W, Fialka I, Teis D, et al. A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment. J Cell Biol 2001;152: 765-76
    • (2001) J Cell Biol , vol.152 , pp. 765-776
    • Wunderlich, W.1    Fialka, I.2    Teis, D.3
  • 76
    • 0035854367 scopus 로고    scopus 로고
    • Endocytosis and signaling. An inseparable partnership
    • Di Fiore PP, De Camilli P. Endocytosis and signaling. An inseparable partnership. Cell 2001;106:1-4
    • (2001) Cell , vol.106 , pp. 1-4
    • Di Fiore, P.P.1    De Camilli, P.2
  • 77
    • 0035139109 scopus 로고    scopus 로고
    • Cellular defenses against unfolded proteins: A cell biologist thinks about neurodegenerative diseases
    • Sherman MY, Goldberg AL. Cellular defenses against unfolded proteins: A cell biologist thinks about neurodegenerative diseases. Neuron 2001;29:15-32
    • (2001) Neuron , vol.29 , pp. 15-32
    • Sherman, M.Y.1    Goldberg, A.L.2
  • 78
    • 0035818998 scopus 로고    scopus 로고
    • Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP
    • Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature 2001;414:643-48
    • (2001) Nature , vol.414 , pp. 643-648
    • Kamal, A.1    Almenar-Queralt, A.2    LeBlanc, J.F.3    Roberts, E.A.4    Goldstein, L.S.5
  • 79
    • 0036468435 scopus 로고    scopus 로고
    • Biomedicine. A cargo receptor mystery apparently solved?
    • Sisodia SS. Biomedicine. A cargo receptor mystery apparently solved? Science 2002;295:805-7
    • (2002) Science , vol.295 , pp. 805-807
    • Sisodia, S.S.1
  • 80
    • 0037128935 scopus 로고    scopus 로고
    • Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
    • Stamer K, Vogel R, Thies E, Mandelkow E, Mandelkow EM. Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J Cell Biol 2002;156: 1051-63
    • (2002) J Cell Biol , vol.156 , pp. 1051-1063
    • Stamer, K.1    Vogel, R.2    Thies, E.3    Mandelkow, E.4    Mandelkow, E.M.5
  • 81
    • 0000138540 scopus 로고    scopus 로고
    • Effects of PS1 deficiency on membrane protein trafficking in neurons
    • Naruse S, Thinakaran G, Luo JJ, et al. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron 1998;21: 1213-21
    • (1998) Neuron , vol.21 , pp. 1213-1221
    • Naruse, S.1    Thinakaran, G.2    Luo, J.J.3
  • 82
    • 0025718569 scopus 로고
    • Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates
    • Koliatsos VE, Clatterbuck RE, Nauta HJ, et al. Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates. Ann Neurol 1991;30:831-40
    • (1991) Ann Neurol , vol.30 , pp. 831-840
    • Koliatsos, V.E.1    Clatterbuck, R.E.2    Nauta, H.J.3
  • 83
    • 0034612256 scopus 로고    scopus 로고
    • Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice
    • Capsoni S, Ugolini G, Comparini A, et al. Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice. Proc Natl Acad Sci U S A 2000;97:6826-31
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 6826-6831
    • Capsoni, S.1    Ugolini, G.2    Comparini, A.3
  • 84
    • 0032559622 scopus 로고    scopus 로고
    • The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death
    • Bamji SX, Majdan M, Pozniak CD, et al. The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death. J Cell Biol 1998;140:911-23
    • (1998) J Cell Biol , vol.140 , pp. 911-923
    • Bamji, S.X.1    Majdan, M.2    Pozniak, C.D.3
  • 85
    • 85038463686 scopus 로고    scopus 로고
    • p75 reduces TrkB tyrosine autophosphorylation in response to BDNF and NT-4/5
    • Record Supplied By Publisher
    • Vesa J, Kruttgen A, Shooter EM. p75 Reduces TrkB Tyrosine Autophosphorylation in Response to BDNF and NT-4/5. [Record Supplied By Publisher]. J Biol Chem 2000;23
    • (2000) J Biol Chem , pp. 23
    • Vesa, J.1    Kruttgen, A.2    Shooter, E.M.3
  • 86
    • 0033004556 scopus 로고    scopus 로고
    • Cellular and molecular determinants of sympathetic neuron development
    • Francis NJ, Landis SC. Cellular and molecular determinants of sympathetic neuron development. Annu Rev Neurosci 1999;22: 541-66
    • (1999) Annu Rev Neurosci , vol.22 , pp. 541-566
    • Francis, N.J.1    Landis, S.C.2
  • 87
    • 2942591228 scopus 로고    scopus 로고
    • Failed retrograde transport of NGF in a mouse model of Down's syndrome: Reversal of cholinergic neurodegenerative phenotypes following NGF infusion
    • Cooper JD, Salehi A, Delcroix JD, et al. Failed retrograde transport of NGF in a mouse model of Down's syndrome: Reversal of cholinergic neurodegenerative phenotypes following NGF infusion. Proc Natl Acad Sci U S A 2001;98:10439-44
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10439-10444
    • Cooper, J.D.1    Salehi, A.2    Delcroix, J.D.3
  • 88
    • 0029022112 scopus 로고
    • Nerve growth factor in Alzheimer's disease: Increased levels throughout the brain coupled with declines in nucleus basalis
    • Scott SA, Mufson EJ, Weingartner JA, Skau KA, Crutcher KA. Nerve growth factor in Alzheimer's disease: Increased levels throughout the brain coupled with declines in nucleus basalis. J Neurosci 1995;15:6213-21
    • (1995) J Neurosci , vol.15 , pp. 6213-6221
    • Scott, S.A.1    Mufson, E.J.2    Weingartner, J.A.3    Skau, K.A.4    Crutcher, K.A.5
  • 89
    • 0024027151 scopus 로고
    • Processing and secretion of nerve growth factor: Expression in mammalian cells with a vaccinia virus vector
    • Edwards RH, Selby MJ, Mobley WC, et al. Processing and secretion of nerve growth factor: Expression in mammalian cells with a vaccinia virus vector. Mol Cell Biol 1988;8:2456-64
    • (1988) Mol Cell Biol , vol.8 , pp. 2456-2464
    • Edwards, R.H.1    Selby, M.J.2    Mobley, W.C.3
  • 90
    • 0035976524 scopus 로고    scopus 로고
    • Regulation of cell survival by secreted proneurotrophins
    • Lee R, Kermani P, Teng KK, Hempstead BL. Regulation of cell survival by secreted proneurotrophins. Science 2001;294:1945-48
    • (2001) Science , vol.294 , pp. 1945-1948
    • Lee, R.1    Kermani, P.2    Teng, K.K.3    Hempstead, B.L.4
  • 91
    • 0035918236 scopus 로고    scopus 로고
    • Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor
    • Mowla SJ, Farhadi HF, Pareek S, et al. Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor. J Biol Chem 2001;276:12660-66
    • (2001) J Biol Chem , vol.276 , pp. 12660-12666
    • Mowla, S.J.1    Farhadi, H.F.2    Pareek, S.3
  • 92
    • 0029845927 scopus 로고    scopus 로고
    • The regulated secretion and vectorial targeting of neurotrophins in neuroendocrine and epithelial cells
    • Heymach JV, Jr, Kruttgen A, Suter U, Shooter EM. The regulated secretion and vectorial targeting of neurotrophins in neuroendocrine and epithelial cells. J Biol Chem 1996;271:25430-37
    • (1996) J Biol Chem , vol.271 , pp. 25430-25437
    • Heymach J.V., Jr.1    Kruttgen, A.2    Suter, U.3    Shooter, E.M.4
  • 93
    • 0033366384 scopus 로고    scopus 로고
    • Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons
    • Williamson TL, Cleveland DW. Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons. Nat Neurosci 1999;2:50-56
    • (1999) Nat Neurosci , vol.2 , pp. 50-56
    • Williamson, T.L.1    Cleveland, D.W.2
  • 94
    • 0036829006 scopus 로고    scopus 로고
    • Neurotrophins: From enthusiastic expectations through sobering experiences to rational therapeutic approaches
    • Thoenen H, Sendtner M. Neurotrophins: From enthusiastic expectations through sobering experiences to rational therapeutic approaches. Nat Neurosci (Suppl) 2002;5:1046-50
    • (2002) Nat Neurosci (Suppl) , vol.5 , pp. 1046-1050
    • Thoenen, H.1    Sendtner, M.2
  • 95
    • 0034721690 scopus 로고    scopus 로고
    • Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    • Kordower JH, Emborg ME, Bloch J, et al. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 2000;290:767-73
    • (2000) Science , vol.290 , pp. 767-773
    • Kordower, J.H.1    Emborg, M.E.2    Bloch, J.3
  • 96
    • 0036674066 scopus 로고    scopus 로고
    • Alzheimer's therapeutics: Neurotrophin small molecule mimetics
    • Massa SM, Xie Y, Longo FM. Alzheimer's therapeutics: Neurotrophin small molecule mimetics. J Mol Neurosci 2002;19:107-11
    • (2002) J Mol Neurosci , vol.19 , pp. 107-111
    • Massa, S.M.1    Xie, Y.2    Longo, F.M.3
  • 97
    • 0029905329 scopus 로고    scopus 로고
    • Protection of the neostriatum against excitotoxic damage by neurotrophin-producing, genetically modified neural stem cells
    • Martinez-Serrano A, Bjorklund A. Protection of the neostriatum against excitotoxic damage by neurotrophin-producing, genetically modified neural stem cells. J Neurosci 1996;16:4604-16
    • (1996) J Neurosci , vol.16 , pp. 4604-4616
    • Martinez-Serrano, A.1    Bjorklund, A.2


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