Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutations

Journal of Neurochemistry

Volumn 75, Issue 5, 2000, Pages 2155-2162

  Goedert, M ^a   Satumtira, S ^a   Jakes, R ^a   Smith, M J ^a   Kamibayashi, C ^a   White, C L ^a   Sontag, E ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

Frontotemporal dementia; Frontotemporal dementia and parkinsonism linked to chromosome 17; Protein phosphatase 2A; Tau mutations

Indexed keywords

HOLOENZYME; ISOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; TAU PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHROMOSOME 17; CHROMOSOME MUTATION; CONTROLLED STUDY; FRONTOTEMPORAL DEMENTIA; GENETIC CODE; GENETIC LINKAGE; GENETIC TRANSFECTION; IMMUNOPRECIPITATION; INTRON; MOUSE; NONHUMAN; PARKINSONISM; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

3T3 CELLS; ANIMAL; BRAIN CHEMISTRY; CELL EXTRACTS; CELLS, CULTURED; CHROMOSOMES, HUMAN, PAIR 17; DEMENTIA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HAPLORHINI; HUMAN; IMMUNOBLOTTING; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION; PARKINSONIAN DISORDERS; PHOSPHOPROTEIN PHOSPHATASE; PRECIPITIN TESTS; PROTEIN BINDING; RATS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TAU PROTEINS; TRANSFECTION;

EID: 0033788787     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0752155.x     Document Type: Article

References (42)

1. Structure and novel exons of the human tau gene
2. 396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding
3. Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau
4. The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology
5. Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17
6. Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation
7. Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements
8. Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
9. Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tan containing four tandem repeats: Differential expression of tau protein mRNAs in human brain
10. p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A: Implications for Alzheimer's disease
11. Protein phosphatase 2A is the major enzyme in brain that dephosphorylares tau protein phosphorylated by proline-directed protein kinases or cyclic AMP-dependent protein kinase
12. Tau gene mutation in familial progressive subcortical gliosis
13. Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments
14. Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau
15. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
16. Domains of tau protein and interactions with microtubules
17. Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly
18. FTDP-17 mutations N279K and S305N in tau produce increased splicing of exon 10
19. Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17
20. Association of missense and 5'-splice-site mutations in tan with the inherited dementia FTDP-17
21. Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: Abundant expression of both forms in cells
22. Stable expression in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)
23. 205 in response to microtubule depolymerization in cultured human neurons involves protein phosphatase 2A
24. Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons
25. Tau pathology in a family with dementia and a P301L mutation in tau
26. Tau gene mutation G389R causes a tauopathy with abundant Pick body-like inclusions and axonal deposits
27. Accelerated filament formation from tau protein with specific FTDP-17 missense mutations
28. Protein phosphatase 2A subunit assembly: The catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen
29. Tau is a candidate gene for chromosome 17 frontotemporal dementia
30. Autosomal dominant dementia with widespread neurofibrillary tangles
31. High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in The Netherlands
32. Regulation of the phosphorylation state and microtubule-binding activity of tau by protein phosphatase 2A
33. Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tan phosphorylation and the development of tauopathies
34. Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles
35. Familial multiple system tauopathy with presenile dementia: A disease with abundant neuronal and glial tau filaments
36. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
37. Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau
38. Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)
39. Phenotypic variation in hereditary frontotemporal dementia with tau mutations
40. Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A
41. A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto)
42. FTDP-17 tau mutations decrease the susceptibility of tau to calpain I digestion