The function of steroid hormone receptors is inhibited by the hsp90- specific compound geldanamycin

Journal of Biological Chemistry

Volumn 272, Issue 30, 1997, Pages 18694-18701

  Segnitz, Bernd ^a   Gehring, Ulrich ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA ETHYL 21 HYDROXY 19 NORPREGN 4 ENE 3,20 DIONE; ANDROGEN; ANSAMYCIN DERIVATIVE; CYCLOHEXIMIDE; ESTROGEN; GELDANAMYCIN; GESTAGEN; GLUCOCORTICOID; HEAT SHOCK PROTEIN 90; IMMUNOPHILIN; PROTEASOME; STEROID HORMONE RECEPTOR BLOCKING AGENT; STEROID RECEPTOR; TRIAMCINOLONE ACETONIDE; UBIQUITIN;

ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CONTROLLED STUDY; GENE EXPRESSION; GENE INDUCTION; HEPATOMA CELL; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; THYMUS LYMPHOMA; TUMOR CELL LINE;

3T3 CELLS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BENZOQUINONES; CARRIER PROTEINS; COS CELLS; DNA-BINDING PROTEINS; ENZYME INHIBITORS; HEAT-SHOCK PROTEINS; HORMONES; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MICE; PROTEIN CONFORMATION; PROTEIN-TYROSINE KINASES; QUINONES; RATS; RECEPTORS, ANDROGEN; RECEPTORS, CELL SURFACE; RECEPTORS, ESTROGEN; RECEPTORS, GLUCOCORTICOID; RECEPTORS, PROGESTERONE; TACROLIMUS BINDING PROTEINS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0030810984     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.30.18694     Document Type: Article

References (50)

1. Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., and Evans, R. M. (1995) Cell 83, 835-839
2. Gronemeyer, H., and Laudet, V. (1995) Protein Profile 2, 1173-1308
3. Bohen, S. P., and Yamamoto, K. R. (1994) in The Biology of Heat Shock Proteins and Molecular Chaperones (Morimoto, R. I., Tissieres, A., and Georgopouios, C., eds) pp. 313-334, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
4. Pratt, W. B., Gehring, U., and Toft, D. O. (1996) in Stress-inducible Cellular Responses (Feige, U., Morimoto, R. I., Yahara, I., and Polla, B. S., eds) pp. 79-95, Birkhäuser, Basel
5. Bresnick, E. H., Dalman, F. C., Sanchez, E. R., and Pratt, W. B. (1989) J. Biol. Chem. 264, 4992-4997
6. Segnitz, B., and Gehring, U. (1990) J. Biol. Chem. 265, 2789-2796
7. Nemoto, T., Ohara-Nemoto, Y., Denis, M., and Gustafsson, J.-Å. (1990) Biochemistry 29, 1880-1886
8. Smith, D. F. (1993) Mol. Endocrinol. 7, 1418-1429
9. Caamano, C. A., Morano, M. I., Patel, P. D., Watson, S. J., and Akil, H. (1993) Biochemistry 32, 8589-8595
10. Uehara, Y., Murakami, Y., Mizuno, S., and Kawai, S. (1988) Virology 164, 294-298
11. June, C. H., Fletcher, M. C., Ledbetter, J. A., Schieven, G. L., Siegel, J. N., Phillips, A. P., and Samelson, L. E. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 7722-7726
12. Hamaguchi, M., Xiao, H., Uehara, Y., Ohnishi, Y., and Nagai, Y. (1993) Oncogene 8, 559-564
13. Migita, K., Eguchi, K., Kawabe, Y., Mizokami, A., Tsukada, T., and Nagataki, S. (1994) J. Immunol. 153, 3457-3465
14. Murakami, Y. Fukazawa, H., Mizuno, S., and Uehara, Y. (1994) Biochem. J. 301, 57-62
15. Okabe, M., Uehara, Y., Noshima, T., Itaya, T., Kunieda, Y., and Kurosawa, M. (1994) Leuk. Res. 18, 867-873
16. Auvinen, M., Paasinen-Sohns, A, Hirai, H., Andersson, L. C., and Hölttä, E. (.1995) Mol. Cell. Biol. 15, 6513-6525
17. Clark, J. W., Santos-Moore, A., Stevenson, L. E., and Frackelton, A. R. (1996) Int. J. Cancer 65, 186-191
18. Whitesell, L., Mimnaugh, E. G., De Costa, B., Myers, C. E., and Neckers, L. M. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 8324-8328
19. Danielsen, M., Northrop, J. P., and Ringold, G. M. (1986) EMBO J. 5, 2513-2522
20. Miesfeld, R., Ruseoni, S., Godowski, P. J., Maler. B. A., Okret, S., Wikström, A.-C., Gustafsson, J.-Å., and Yamamoto, K. R. (1986) Cell 46, 389-399
21. Gehring, U., Mugele, K., Arndt, H., and Busch, W. (1987) Mol. Cell. Endocrinol. 53, 33-44
22. Rexin, M., Busch, W., and Gehring, U. (1991) J. Biol. Chem. 266, 24601-24605
23. Segnitz, B., and Gehring, U. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 2179-2183
24. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., and Struhl, K. (1995) Current Protocols in Molecular Biology, John Wiley & Sons, Inc., New York
25. Hayashi, S., Granner, D. K., and Tomkins, G. M. (1967) J. Biol. Chem. 242, 3998-4006
26. Spindler-Barth, M., and Gehring, U. (1982) FEBS Lett. 138, 91-94
27. Westphal, H. M., Moldenhauer, G., and Beato, M. (1982) EMBO J. 1, 1467-1471
28. Harrison, R. W., Hendry, W. J., Turney, M., Kunkel, E., Thompson, E., Denton, R. A., and Gametchu, B. (1987) in Recent Advances in Steroid Hormone Action (Moudgil, V. K., ed) pp. 467-475, Walter de Gruyter, Berlin
29. Rexin, M., Busch, W., and Gehring, U. (1988) Biochemistry 27, 5593-5601
30. Schmitt, J., Pohl, J., and Stunnenberg, H. G. (1993) Gene (Amst.) 132, 267-271
31. Johnson, J. L., Beito, T. G., Krco, C. J., and Toft, D. O. (1994) Mol. Cell. Biol. 14, 1956-1963
32. Härtig, E., Nierlich, B., Mink, S., Nebl, G., and Cato, A. C. B. (1993) J. Virol. 67, 813-821
33. Nemoto, T., Ohara-Nemoto, Y., and Ota, M. (1992) J. Steroid Biochem. Mol. Biol. 42, 803-812
34. Fenteany, G., Standaert, R. F., Lane, W. S., Choi, S., Corey, E. J., and Schreiber, S. L. (1995) Science 268, 726-731
35. Kulka, R. G., Raboy, B., Schuster, R., Parag, H. A., Diamond, G., Ciechanover, A., and Marcus, M. (1988) J. Biol. Chem. 263, 15726-15731
36. Jakob, U., and Buchner, J. (1994) Trends Biochem. Sci. 19, 205-211
37. Borkovich, K. A., Farrelly, F. W., Finkelstein, D. B., Taulien, J., and Lindquist, S. (1989) Mol. Cell. Biol. 9, 3919-3930
38. Hu, J., and Seeger, C. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 1060-1064
39. Whitesell, L., and Cook, P. (1996) Mol. Endocrinol. 10, 705-712
40. Smith, D. F., Whitesell, L., Nair, S. C., Chen, S., Prapapanich, V., and Rimerman, R. A. (1995) Mol. Cell. Biol. 15, 6804-6812
41. Johnson, J. L., and Toft, D. O. (1995) Mol. Endocrinol. 9, 670-678
42. Dittmar, K. D., Hutchison, K. A., Owens-Grillo, J. K., and Pratt, W. B. (1996) J. Biol. Chem. 271, 12833-12839
43. Blagosklonny, M. V., Toretsky, J., and Neckers, L. (1995) Oncogene 11, 933-939
44. Hartl, F. U. (1996) Nature 381, 571-580
45. Simons, S. S., Jr. (1994) in Vitamins and Hormones (Litwack, G., ed) Vol. 49, pp. 49-130, Academic Press, New York
46. Hershko, A., and Ciechanover, A. (1992) Annu. Rev. Biochem. 61, 761-807
47. Coux, O., Tanaka, K., and Goldberg, A. L. (1996) Annu. Rev. Biochem. 65, 801-847
48. Chavany, C., Mimnaugh, E., Miller, P., Bitton, R., Nguyen, P., Trepel, J., Whitesell, L., Schnur, R., Moyer, J. D., and Neckers, L. (1996) J. Biol. Chem. 271, 4974-4977
49. Sepp-Lorenzino, L., Ma, Z., Lebwohl, D. E., Vinitzky, A., and Rosen, N. (1995) J. Biol. Chem. 270, 16580-16587
50. Mimnaugh, E. G., Chavany, C., and Neckers, L. (1996) J. Biol. Chem. 271, 22796-22801