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Volumn 21, Issue 1, 2003, Pages 67-76

The P2Y1 receptor as a target for new antithrombotic drugs: A review of the P2Y1 antagonist MRS-2179

Author keywords

Antithrombotics; MRS 2179; P2Y1 receptor antagonists; Platelet aggregation; Thrombosis

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 2 CHLORO N6 METHYLMETHANOCARBA 2' DEOXYADENOSINE 3',5' BISPHOSPHATE; 2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; 8 (2' DEOXY BETA DEXTRO RIBOFURANOSYL) 2 METHYL 4 (N METHYLAMINO)PYRAZOLO[1,5 A] 1,3,5 TRIAZINE 3',5' BISPHOSPHATE; ADENOSINE 3',5' BISPHOSPHATE; ANTICOAGULANT AGENT; AR C 69931MX; CLOPIDOGREL; FIBRINOGEN RECEPTOR ANTAGONIST; LOW MOLECULAR WEIGHT HEPARIN; MRS 2216; MRS 2279; N6 (2 METHYLTHIOETHYL) 2 (3,3,3 TRIFLUOROPROPYLTHIO) BETA DICHLOROMETHYLENE ATP; NCS 769; PURINE P2Y RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PYRIDINE DERIVATIVE; THROMBIN INHIBITOR; TICLOPIDINE; UNCLASSIFIED DRUG;

EID: 0037255494     PISSN: 08975957     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3466.2003.tb00106.x     Document Type: Review
Times cited : (58)

References (52)
  • 2
    • 0035120357 scopus 로고    scopus 로고
    • Novel platelet inhibitors
    • Bennett JS. Novel platelet inhibitors. Annu Rev Med 2001;52:161-184.
    • (2001) Annu Rev Med , vol.52 , pp. 161-184
    • Bennett, J.S.1
  • 3
    • 0023738061 scopus 로고
    • The role of platelets and ADP in experimental thrombosis induced by venous stasis in the rat
    • Bernat A, Vallee E, Maffrand JP, Gordon JL. The role of platelets and ADP in experimental thrombosis induced by venous stasis in the rat. Thromb Res 1988;52:65-70.
    • (1988) Thromb Res , vol.52 , pp. 65-70
    • Bernat, A.1    Vallee, E.2    Maffrand, J.P.3    Gordon, J.L.4
  • 4
    • 0036245650 scopus 로고    scopus 로고
    • 2-Chloro N(6)-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′- bisphosphate is a selective high affinity P2Y(1) receptor antagonist
    • Boyer JL, Adams M, Ravi RG, Jacobson KA, Harden TK. 2-Chloro N(6)-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′- bisphosphate is a selective high affinity P2Y(1) receptor antagonist. Br J Pharmacol 2002;135:2004-2010.
    • (2002) Br J Pharmacol , vol.135 , pp. 2004-2010
    • Boyer, J.L.1    Adams, M.2    Ravi, R.G.3    Jacobson, K.A.4    Harden, T.K.5
  • 8
    • 0028170436 scopus 로고
    • Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors
    • Boyer JL, Zohn IE, Jacobson KA, Harden TK. Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors. Br J Pharmacol 1994;113:614-620.
    • (1994) Br J Pharmacol , vol.113 , pp. 614-620
    • Boyer, J.L.1    Zohn, I.E.2    Jacobson, K.A.3    Harden, T.K.4
  • 9
    • 0033942979 scopus 로고    scopus 로고
    • Activity of novel adenine nucleotide derivatives as agonists and antagonists at recombinant rat P2X receptors
    • Brown S, King B, Kim Y, Jang S, Burnstock G, Jacobson K. Activity of novel adenine nucleotide derivatives as agonists and antagonists at recombinant rat P2X receptors. Drug Dev Res 2000;49:253-259.
    • (2000) Drug Dev Res , vol.49 , pp. 253-259
    • Brown, S.1    King, B.2    Kim, Y.3    Jang, S.4    Burnstock, G.5    Jacobson, K.6
  • 10
    • 0028177926 scopus 로고
    • P2-purinoceptor antagonists discriminate three contraction-mediating receptors for ATP in rat vas deferens
    • Bultmann R, Starke K. P2-purinoceptor antagonists discriminate three contraction-mediating receptors for ATP in rat vas deferens. Naunyn Schmiedeberg's Arch Pharmacol 1994;349:74-80.
    • (1994) Naunyn Schmiedeberg's Arch Pharmacol , vol.349 , pp. 74-80
    • Bultmann, R.1    Starke, K.2
  • 12
    • 0030590746 scopus 로고    scopus 로고
    • A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
    • CAPRIE Steering Committee
    • CAPRIE. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet 1996;348:1329-1339.
    • (1996) Lancet , vol.348 , pp. 1329-1339
  • 15
    • 0032483024 scopus 로고    scopus 로고
    • A mouse model of severe von Willebrand disease: Defects in hemostasis and thrombosis
    • Denis C, Methia N, Frenette PS, et al. A mouse model of severe von Willebrand disease: Defects in hemostasis and thrombosis. Proc Natl Acad Sci USA 1998;95:9524-9529.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9524-9529
    • Denis, C.1    Methia, N.2    Frenette, P.S.3
  • 17
    • 0031596463 scopus 로고    scopus 로고
    • 1-receptors in human platelets which are pharmacologically distinct from P2Y(ADP)-receptors
    • 1-receptors in human platelets which are pharmacologically distinct from P2Y(ADP)-receptors. Br J Pharmacol 1998;124:157-164.
    • (1998) Br J Pharmacol , vol.124 , pp. 157-164
    • Fagura, M.S.1    Dainty, I.A.2    McKay, G.D.3
  • 18
    • 0034978187 scopus 로고    scopus 로고
    • Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs
    • Foster CJ, Prosser DM, Agans JM, et al. Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs. J Clin Invest 2001;107:1591-1598.
    • (2001) J Clin Invest , vol.107 , pp. 1591-1598
    • Foster, C.J.1    Prosser, D.M.2    Agans, J.M.3
  • 19
    • 0034911702 scopus 로고    scopus 로고
    • ADP receptors of platelets and their inhibition
    • Gachet C. ADP receptors of platelets and their inhibition. Thromb Haemost 2001;86:222-232.
    • (2001) Thromb Haemost , vol.86 , pp. 222-232
    • Gachet, C.1
  • 20
    • 0029140433 scopus 로고
    • P2-purinergic receptors: Subtype-associated signaling responses and structure
    • Harden TK, Boyer JL, Nicholas RA. P2-purinergic receptors: Subtype-associated signaling responses and structure. Annu Rev Pharmacol Toxicol 1995;35:541-579.
    • (1995) Annu Rev Pharmacol Toxicol , vol.35 , pp. 541-579
    • Harden, T.K.1    Boyer, J.L.2    Nicholas, R.A.3
  • 21
    • 0015525988 scopus 로고
    • The bleeding time as a screening test for evaluation of platelet function
    • Harker LA, Slichter SJ. The bleeding time as a screening test for evaluation of platelet function. N Engl J Med 1972;287:155-159.
    • (1972) N Engl J Med , vol.287 , pp. 155-159
    • Harker, L.A.1    Slichter, S.J.2
  • 22
    • 0031593698 scopus 로고    scopus 로고
    • 1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel
    • 1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel. Br J Haematol 1998;103:858-866.
    • (1998) Br J Haematol , vol.103 , pp. 858-866
    • Hechler, B.1    Eckly, A.2    Ohlmann, P.3    Cazenave, J.P.4    Gachet, C.5
  • 23
    • 0032105512 scopus 로고    scopus 로고
    • 1 receptor is necessary for adenosine 5′-diphosphate-induced platelet aggregation
    • 1 receptor is necessary for adenosine 5′-diphosphate-induced platelet aggregation. Blood 1998;92:152-159.
    • (1998) Blood , vol.92 , pp. 152-159
    • Hechler, B.1    Leon, C.2    Vial, C.3
  • 25
    • 0033058683 scopus 로고    scopus 로고
    • Effect of clopidogrel on thrombin generation in plateletrich plasma in the rat
    • Herault JP, Dol F, Gaich C, Bernat A, Herbert JM. Effect of clopidogrel on thrombin generation in plateletrich plasma in the rat. Thromb Haemost 1999;81:957-960.
    • (1999) Thromb Haemost , vol.81 , pp. 957-960
    • Herault, J.P.1    Dol, F.2    Gaich, C.3    Bernat, A.4    Herbert, J.M.5
  • 26
    • 0031884176 scopus 로고    scopus 로고
    • Effect of SR121566A, a potent GP IIb-Illa antagonist on platelet-mediated thrombin generation in vitro and in vivo
    • Herault JP, Peyrou V, Savi P, Bernat A, Herbert JM. Effect of SR121566A, a potent GP IIb-Illa antagonist on platelet-mediated thrombin generation in vitro and in vivo. Thromb Haemost 1998;79:383-388.
    • (1998) Thromb Haemost , vol.79 , pp. 383-388
    • Herault, J.P.1    Peyrou, V.2    Savi, P.3    Bernat, A.4    Herbert, J.M.5
  • 27
    • 0026806029 scopus 로고
    • Importance of platelets in experimental venous thrombosis in the rat
    • Herbert JM, Bernat A, Maffrand JP. Importance of platelets in experimental venous thrombosis in the rat. Blood 1992;80:2281-2286.
    • (1992) Blood , vol.80 , pp. 2281-2286
    • Herbert, J.M.1    Bernat, A.2    Maffrand, J.P.3
  • 28
    • 0035843178 scopus 로고    scopus 로고
    • Identification of the platelet ADP receptor targeted by antithrombotic drugs
    • Hollopeter G, Jantzen HM, Vincent D, et al. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 2001;409:202-207.
    • (2001) Nature , vol.409 , pp. 202-207
    • Hollopeter, G.1    Jantzen, H.M.2    Vincent, D.3
  • 29
    • 0002588159 scopus 로고    scopus 로고
    • Pharmacology of the platelet ADP receptors: Agonists and antagonists
    • Hourani SMO. Pharmacology of the platelet ADP receptors: Agonists and antagonists. Haematologica 2000;85:58-65.
    • (2000) Haematologica , vol.85 , pp. 58-65
    • Hourani, S.M.O.1
  • 30
    • 0002494462 scopus 로고    scopus 로고
    • Pharmacology of AR-C69931MX and related compounds: From pharmacological tools to clinical trials
    • Humphries RG. Pharmacology of AR-C69931MX and related compounds: from pharmacological tools to clinical trials. Haematologica 2000;85:66-72.
    • (2000) Haematologica , vol.85 , pp. 66-72
    • Humphries, R.G.1
  • 31
    • 0027942835 scopus 로고
    • FPL 66096: A novel, highly potent and selective antagonist at human platelet P2T-purinoceptors
    • Humphries RG, Tomlinson W, Ingall AH, Cage PA, Leff P. FPL 66096: A novel, highly potent and selective antagonist at human platelet P2T-purinoceptors. Br J Pharmacol 1994;113:1057-1063.
    • (1994) Br J Pharmacol , vol.113 , pp. 1057-1063
    • Humphries, R.G.1    Tomlinson, W.2    Ingall, A.H.3    Cage, P.A.4    Leff, P.5
  • 32
    • 0032589747 scopus 로고    scopus 로고
    • Antagonists of the platelet P2T receptor: A novel approach to antithrombotic therapy
    • Ingall AH, Dixon J, Bailey A, et al. Antagonists of the platelet P2T receptor: A novel approach to antithrombotic therapy. J Med Chem 1999;42:213-220.
    • (1999) J Med Chem , vol.42 , pp. 213-220
    • Ingall, A.H.1    Dixon, J.2    Bailey, A.3
  • 33
    • 0347087688 scopus 로고    scopus 로고
    • Interaction of ribose-modified nucleotides with P2Y receptors in platelets
    • Jacobson KA, Xu B, Cattaneo M, et al. Interaction of ribose-modified nucleotides with P2Y receptors in platelets. Haematologica 2002;87(Suppl):3-4.
    • (2002) Haematologica , vol.87 , Issue.SUPPL. , pp. 3-4
    • Jacobson, K.A.1    Xu, B.2    Cattaneo, M.3
  • 34
    • 0032493295 scopus 로고    scopus 로고
    • Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation
    • Jin J, Kunapuli SP. Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation. Proc Natl Nall Acad Sci USA 1998;95:8070-8074.
    • (1998) Proc Natl Nall Acad Sci USA , vol.95 , pp. 8070-8074
    • Jin, J.1    Kunapuli, S.P.2
  • 36
    • 0034003967 scopus 로고    scopus 로고
    • Acyclic analogues of deoxyadenosine 3′,5′-bisphosphates as P2Y(1) receptor antagonists
    • Kim YC, Gallo-Rodriguez C, Jang SY, et al. Acyclic analogues of deoxyadenosine 3′,5′-bisphosphates as P2Y(1) receptor antagonists. J Med Chem 2000;43:746-755.
    • (2000) J Med Chem , vol.43 , pp. 746-755
    • Kim, Y.C.1    Gallo-Rodriguez, C.2    Jang, S.Y.3
  • 37
    • 0026684355 scopus 로고
    • PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses
    • Lambrecht G, Friebe T, Grimm U, et al. PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses. Eur J Pharmacol 1992;217:217-219.
    • (1992) Eur J Pharmacol , vol.217 , pp. 217-219
    • Lambrecht, G.1    Friebe, T.2    Grimm, U.3
  • 45
    • 0032879820 scopus 로고    scopus 로고
    • Ticlopidine and clopidogrel
    • Quinn MJ, Fitzgerald DJ. Ticlopidine and clopidogrel. Circulation 1999;100:1667-1672.
    • (1999) Circulation , vol.100 , pp. 1667-1672
    • Quinn, M.J.1    Fitzgerald, D.J.2
  • 46
    • 0037075075 scopus 로고    scopus 로고
    • 1 purinergic receptor: Synthesis and conformational analysis using potentiometric and nuclear magnetic resonance titration techniques
    • 1 purinergic receptor: Synthesis and conformational analysis using potentiometric and nuclear magnetic resonance titration techniques. J Med Chem 2002;45:962-972.
    • (2002) J Med Chem , vol.45 , pp. 962-972
    • Raboisson, P.1    Baurand, A.2    Cazenave, J.P.3
  • 48
    • 0034663385 scopus 로고    scopus 로고
    • The use of glycoprotein IIb/IIIa inhibitors in patients with coronary artery disease
    • Sabatine MS, Jang IK. The use of glycoprotein IIb/IIIa inhibitors in patients with coronary artery disease. Am J Med 2000;109:224-237.
    • (2000) Am J Med , vol.109 , pp. 224-237
    • Sabatine, M.S.1    Jang, I.K.2
  • 50
    • 0035085132 scopus 로고    scopus 로고
    • Open multicentre study of the P2T receptor antagonist AR-C69931MX assessing safety, tolerability and activity in patients with acute coronary syndromes
    • Storey RF, Oldroyd KG, Wilcox RG. Open multicentre study of the P2T receptor antagonist AR-C69931MX assessing safety, tolerability and activity in patients with acute coronary syndromes. Thromb Haemost 2001;85:401-407.
    • (2001) Thromb Haemost , vol.85 , pp. 401-407
    • Storey, R.F.1    Oldroyd, K.G.2    Wilcox, R.G.3
  • 51
    • 0346457343 scopus 로고    scopus 로고
    • Characterization of the P2T receptor antagonist properties of AR-C69931MX in human washed platelets in vitro
    • Tomlinson W, Cusworth E, Midha A, Kirk IP, Humphries RG, Leff P. Characterization of the P2T receptor antagonist properties of AR-C69931MX in human washed platelets in vitro. Haematologica 2000;85(Suppl):95-96.
    • (2000) Haematologica , vol.85 , Issue.SUPPL. , pp. 95-96
    • Tomlinson, W.1    Cusworth, E.2    Midha, A.3    Kirk, I.P.4    Humphries, R.G.5    Leff, P.6
  • 52
    • 0027377639 scopus 로고
    • PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder
    • Ziganshin AU, Hoyle CH, Bo X, et al. PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder. Br J Pharmacol 1993;110:1491-1495.
    • (1993) Br J Pharmacol , vol.110 , pp. 1491-1495
    • Ziganshin, A.U.1    Hoyle, C.H.2    Bo, X.3


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