Acyclic and cyclopropyl analogues of adenosine bisphosphate antagonists of the P2Y1 receptor: Structure-activity relationships and receptor docking

Journal of Medicinal Chemistry

Volumn 44, Issue 19, 2001, Pages 3092-3108

  Hak Sung Kim, ^a   Barak, D ^a,c   Harden, T K ^b   Boyer, J L ^b   Jacobson, K A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 (2 CHLORO 6 METHYLAMINOPURIN 9 YL)METHYL]PROPANE 1,3 BISOXY(DIAMMONIUMPHOSPHATE); ADENOSINE DERIVATIVE; CYCLOPROPANE DERIVATIVE; PHOSPHOLIPASE C; PURINE P2Y RECEPTOR; PURINE P2Y1 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ERYTHROCYTE MEMBRANE; NONHUMAN; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; TURKEY (BIRD);

ADENOSINE DIPHOSPHATE; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME ACTIVATION; ENZYME INHIBITORS; ERYTHROCYTE MEMBRANE; INOSITOL PHOSPHATES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; PHOSPHOLIPASE C; RECEPTORS, PURINERGIC P2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TURKEY;

EID: 0035855916     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010082h     Document Type: Article

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