Activity of novel adenine nucleotide derivatives as agonists and antagonists at recombinant rat P2X receptors

Drug Development Research

Volumn 49, Issue 4, 2000, Pages 253-259

  Brown, Sean G ^a   King, Brian F ^a   Kim, Yong Chul ^b   Jang, Soo Yeon ^b   Burnstock, Geoffrey ^a   Jacobson, Kenneth A ^b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

ATP derivatives; Bisphosphates; Deoxyadenosine derivatives; Ion channel; Oocytes; Purines

Indexed keywords

2 (HEXYLTHIO)ADENOSINE 5' MONOPHOSPHATE; 2 [2 (4 AMINOPHENYL)ETHYLTHIO]ADENOSINE 5' TRIPHOSPHATE; 2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; ADENINE NUCLEOTIDE DERIVATIVE; MRS 2209; MRS 2269; MRS 2286; PURINE P2X RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; NONHUMAN; OOCYTE; RAT; XENOPUS;

EID: 0033942979     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2299(200004)49:4<253::AID-DDR4>3.0.CO;2-1     Document Type: Article

References (26)

1. Abbracchio MP, Burnstock G. 1994. Purinoceptors - are there families of P2x and P2y purinoceptors? Pharmacol Ther 64:445-475.
2. Bianchi BR, Lynch KJ, Touma E, Niforatos W, Burgard EC, Alexander KM, Park HS, Yu H, Metzger R, Kowaluk E, Jarvis M, van Biesen T. 1999. Pharmacological characterization of recombinant human and rat P2X receptor subtypes. Eur J Pharmacol 376:127-138.
3. Boyer JL, Siddiqi S, Fischer B, Romera-Avila T, Jacobson KA, Harden TK. 1996. Identification of potent P2Y purinoceptor agonists that are derivatives of adenosine 5′-monophosphate. Br J Pharmacol 118:1959-1964.
4. 6-methyl 2′-deoxyadenosine 3′,5′-bisphosphate. Br J Pharmacol 124:1-3.
5. Burgard EC, Niforatos W, van Biesen T, Lynch KJ, Touma E, Metzger R, Kowaluk E, Jarvis M. 1999. P2X receptor-mediated ionic currents in dorsal root ganglion neurons. J Neurophysiol 82:1590-1598.
6. Burnstock G. 1996. P2 purinoceptors - historical-perspective and classification. Ciba Found Symp 198:1-34.
7. Burnstock G, King BF 1996. Numbering of cloned P2 purinoceptors. Drug Dev Res 38:67-71.
8. 1 receptors. J Med Chem 41:183-190.
9. Communi D, Boeynaems JM. 1997. Receptors responsive to extracellular pyrimidine nucleotides. Trends Pharmacol Sci 18:83-86.
10. Communi D, Govaerts C, Parmentier M, Boeynaems JM. 1997. Cloning of a human purinergic P2Y receptor-coupled to phospholipase C and adenylyl cyclase. J Biol Chem 272:31969-31973.
11. 1-receptors in human platelets which are pharmacologically distinct from P2YADP-receptors. Br J Pharmacol 124:157-164.
12. Fischer B. 1999. Therapeutic applications of ATP-(P2)-receptors agonists and antagonists. Expert Opin Ther Patents 9:385-399.
13. Fischer B, Boyer JL, Hoyle CHV, Ziganshin AU, Brizzolara AL, Knight GE, Zimmet J, Burnstock G, Harden TK, Jacobson KA. 1993. Identification of potent, selective P2Y-purinoceptor agonists: structure activity relationships for 2-thioether derivatives of adenosine-5′-triphosphate. J Med Chem 36:3937-3946.
14. Fredholm BB, Abbracchio MP, Burnstock G, Dubyak GR, Harden TK, Jacobson KA, Schwabe U, Williams M. 1997. Toward a revised nomenclature for P1 and P2 receptors. Trends Pharmacol Sci 18:79-82.
15. 1 receptor is necessary for adenosine 5′-diphosphate-induced platelet aggregation. Blood 92:152-159.
16. 2T receptor: a novel approach to antithrombotic therapy. J Med Chem 42:213-220.
17. Jacobson KA, Kim YC, Camaioni E, van Rhee AM. 1997. Structure activity relationships of P2 receptor agonists and antagonists. In: Turner JT, Weisman G, Fedan J, editors. The P2 nucleotide receptors (in the series The Receptors). Clifton, NJ: Humana Press, p 81-107.
18. 1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. J Biol Chem 273:2030-2034.
19. 1 receptor antagonists. J Med Chem (in press).
20. King BF. 1998. Molecular biology of P2X purinoceptors. In: Burnstock G, Dobson JG, Liang BT, Linden J, editors. Cardiovascular biology of purines. London: Kluwer. p 159-186.
21. 2 receptor. Br J Pharmacol 121:1445-1453.
22. Lambrecht G, Ardanuy U, Baumert HG, Bo X, Hoyle CHV, Nickel P, Pfaff O, Ralevic V, Windschief U, Zigashin AU, Ziyal R, Mutscheler E, Burnstock G. 1996. Design and pharmacological characterization of selective P2-purinoceptor antagonists. In: Illes P, Zimmerman H, editors. Perspectives in receptor research. Amsterdam: Elsevier, p 337-350.
23. 1 receptor antagonists and partial agonists. J Med Chem 42:1625-1638.
24. North RA, Barnard EA. 1997. Nucleotide receptors. Curr Opin Neurobiol 7:346-357.
25. Williams M, Bhagwat SS. 1996. P2 purinoceptors: a family of novel therapeutic targets. In: Bristol JA, editor. Annu Rep Med Chem 31:21-30.
26. Zimmet J, Järlebark L, van Galen PJM, Jacobson KA, Heilbronn E. 1993. Synthesis and biological activity of novel 2-thio derivatives of ATP. Nucleosides Nucleotides 12:1-20.