A general approach toward the synthesis of C-nucleoside pyrazolo[1,5-a]-1,3,5-triazines and their 3′,5′-bisphosphate C-nucleotide analogues as the first reported in vivo stable P2Y1-receptor antagonists

Journal of Organic Chemistry

Volumn 67, Issue 23, 2002, Pages 8063-8071

  Raboisson, Pierre ^a,c   Baurand, Anthony ^b   Cazenave, Jean Pierre ^b   Gachet, Christian ^b   Schultz, Dominique ^a   Spiess, Bernard ^a   Bourguignon, Jean Jacques ^a  

^a Laboratoire de Pharmacochimie   (France)

^b INSERM   (France)

^c JOHNSON AND JOHNSON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METABOLIC STABILITIES;

DERIVATIVES; KETONES; METABOLISM; NITROGEN COMPOUNDS; PHOSPHATES; SYNTHESIS (CHEMICAL);

STEREOCHEMISTRY;

1,4 ANHYDRO 2 DEOXY DEXTRO ERYTHRO PENT 1 ENITOL; 8 (2' DEOXY BETA DEXTRO RIBOFURANOSYL) 2 METHYL 4 (N METHYLAMINO)PYRAZOLO[1,5 A] 1,3,5 TRIAZINE; 8 (2' DEOXY BETA DEXTRO RIBOFURANOSYL) 2 METHYL 4 (N METHYLAMINO)PYRAZOLO[1,5 A] 1,3,5 TRIAZINE 3',5' BISPHOSPHATE; 8 (2' DEOXY BETA DEXTRO XYLOFURANOSYL) 2 METHYL 4 (N METHYLAMINO)PYRAZOLO[1,5 A] 1,3,5 TRIAZINE; 8 (2' DEOXY BETA DEXTRO XYLOFURANOSYL) 2 METHYL 4 (N METHYLAMINO)PYRAZOLO[1,5 A] 1,3,5 TRIAZINE 3',5' CYCLIC PHOSPHATE; ANILINE DERIVATIVE; ANTITHROMBOCYTIC AGENT; C NUCLEOSIDE; DIMETHYLANILINE; FURAN DERIVATIVE; KETONE DERIVATIVE; METHYLAMINE; PHOSPHORUS DERIVATIVE; PHOSPHORUS OXYCHLORIDE; PURINE P2Y RECEPTOR; PURINE P2Y1 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PYRAZOLE DERIVATIVE; PYRAZOLO[1,5 A] 1,3,5 TRIAZIN 4 ONE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; ADENOSINE DIPHOSPHATE; BISPHOSPHATIDIC ACID; NUCLEOSIDE; NUCLEOTIDE; PHOSPHATIDIC ACID; PURINE P2 RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL REACTION; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MALE; NONHUMAN; RAT; STEREOCHEMISTRY; STEREOSPECIFICITY; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE SHAPE; ANIMAL; DRUG ANTAGONISM; SYNTHESIS; THROMBOCYTE; THROMBOCYTE ACTIVATION;

ADENOSINE DIPHOSPHATE; ANIMALS; BLOOD PLATELETS; HUMANS; NUCLEOSIDES; NUCLEOTIDES; PHOSPHATIDIC ACIDS; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; RATS; RECEPTORS, PURINERGIC P2; TRIAZINES;

EID: 0037111712     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo026268l     Document Type: Article

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