Prospects for pharmacologic inhibition of hepatic glucose production

Current Medicinal Chemistry

Volumn 10, Issue 2, 2003, Pages 99-121

  Kurukulasuriya, R ^a   Link, J T ^a   Madar, D J ^a   Pei, Z ^a   Rohde, J J ^a   Richards, S J ^a   Souers, A J ^a   Szczepankiewicz, B G ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Diabetes; Gluconeogenesis; Glycogenolysis; Hepatic glucose production; Hyperglycemia; Liver; Liver targeting; Metformin

Indexed keywords

2 TERT BUTYL 2 (4 METHYLPHENYL) 1,3 DIOXOLANE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ACARBOSE; ANTIDIABETIC AGENT; BILE ACID; CARBOXYLIC ACID DERIVATIVE; CHOLIC ACID DERIVATIVE; DRUG METABOLITE; ESTER DERIVATIVE; ETHER DERIVATIVE; FRUCTOSE BISPHOSPHATASE; GLUCAGON RECEPTOR; GLUCOCORTICOID RECEPTOR; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCURONIDE; GLYCOGEN; GLYCOGEN PHOSPHORYLASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; LACTONE DERIVATIVE; LIPID; METFORMIN; MEVINOLIN; PRAVASTATIN; PRODRUG; SULFONYLUREA DERIVATIVE; TAUROCHOLIC ACID; TRACER; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANALYTIC METHOD; CELL COMPOSITION; DIGESTIVE SYSTEM FUNCTION DISORDER; DOSE RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG LIVER LEVEL; DRUG POTENTIATION; DRUG RESEARCH; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; ENTEROHEPATIC CIRCULATION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLYCOGENOLYSIS; HUMAN; LACTIC ACIDOSIS; LIVER BLOOD FLOW; LIVER CELL; LIVER FUNCTION; LIVER STRUCTURE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; RAT; REVIEW; STRUCTURE ACTIVITY RELATION; URINARY EXCRETION;

EID: 0037247641     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867033368547     Document Type: Review

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